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    LIF LIF, interleukin 6 family cytokine [ Homo sapiens (human) ]

    Gene ID: 3976, updated on 23-Nov-2017
    Official Symbol
    LIFprovided by HGNC
    Official Full Name
    LIF, interleukin 6 family cytokineprovided by HGNC
    Primary source
    HGNC:HGNC:6596
    See related
    Ensembl:ENSG00000128342 MIM:159540; Vega:OTTHUMG00000150910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDF; DIA; HILDA; MLPLI
    Summary
    The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
    Expression
    Broad expression in gall bladder (RPKM 20.9), appendix (RPKM 11.6) and 16 other tissues See more
    Orthologs
    Location:
    22q12.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 22 NC_000022.11 (30240447..30246851, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30636436..30642840, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene HORMA domain containing 2 Neighboring gene ribosomal protein S3a pseudogene 51 Neighboring gene uncharacterized LOC105372988 Neighboring gene uncharacterized LOC91370 Neighboring gene oncostatin M Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common variants at five new loci associated with early-onset inflammatory bowel disease.
    NHGRI GWA Catalog
    Genome-wide association study identifies susceptibility loci for IgA nephropathy.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of leukemia inhibitory factor (LIF) expression as compared to untreated control PubMed
    env Pretreatment of MAGI cells with human leukemia inhibitory factor results in a significantly reduced uptake of HIV-1 particles and downregulation of HIV-1 mediated STAT3 phosphorylation PubMed
    env HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs PubMed
    capsid gag Human LIF protein upregulates HIV-1 p24 production in the chronically infected promonocytes in a dose-dependent manner PubMed

    Go to the HIV-1, Human Interaction Database

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      Direct p53 effectors
    • IL-6-type cytokine receptor ligand interactions, organism-specific biosystem (from REACTOME)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukemia inhibitory factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukemia inhibitory factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    decidualization IEA
    Inferred from Electronic Annotation
    more info
     
    embryo implantation IEA
    Inferred from Electronic Annotation
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    leukemia inhibitory factor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lung alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    lung lobe morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    lung vasculature development IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development TAS
    Traceable Author Statement
    more info
    PubMed 
    muscle organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of astrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of histone H3-K27 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of macrophage differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of RNA polymerase II regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of metanephric nephron tubule epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    spongiotrophoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    trophoblast giant cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IC
    Inferred by Curator
    more info
    PubMed 
    Preferred Names
    leukemia inhibitory factor
    Names
    D factor
    cholinergic differentiation factor
    differentiation inhibitory activity
    differentiation-inducing factor
    differentiation-stimulating factor
    hepatocyte-stimulating factor III
    human interleukin in DA cells
    melanoma-derived LPL inhibitor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008721.1 RefSeqGene

      Range
      4957..11361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001257135.1NP_001244064.1  leukemia inhibitory factor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC004264, AI796373, BC143305, CN409458
      Consensus CDS
      CCDS58799.1
      UniProtKB/Swiss-Prot
      P15018
      Related
      ENSP00000384450.3, OTTHUMP00000198699, ENST00000403987.3, OTTHUMT00000320509
    2. NM_002309.4NP_002300.1  leukemia inhibitory factor isoform 1 precursor

      See identical proteins and their annotated locations for NP_002300.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC004264, AI796373, CN409458
      Consensus CDS
      CCDS13872.1
      UniProtKB/Swiss-Prot
      P15018
      Related
      ENSP00000249075.3, OTTHUMP00000198698, ENST00000249075.3, OTTHUMT00000320508
      Conserved Domains (1) summary
      smart00080
      Location:34191
      LIF_OSM; leukemia inhibitory factor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p7 Primary Assembly

      Range
      30240447..30246851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018933.2 Alternate CHM1_1.1

      Range
      30595573..30601977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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