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    MPO myeloperoxidase [ Homo sapiens (human) ]

    Gene ID: 4353, updated on 19-Nov-2017
    Official Symbol
    MPOprovided by HGNC
    Official Full Name
    myeloperoxidaseprovided by HGNC
    Primary source
    HGNC:HGNC:7218
    See related
    Ensembl:ENSG00000005381 MIM:606989; Vega:OTTHUMG00000178922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
    Orthologs
    Location:
    17q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (58269856..58280935, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (56347217..56358296, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371841 Neighboring gene Meckel syndrome, type 1 Neighboring gene lactoperoxidase Neighboring gene TSPO associated protein 1 Neighboring gene TSPOAP1 antisense RNA 1 Neighboring gene microRNA 142

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Alzheimer's disease Compare labs
    Myeloperoxidase deficiency
    MedGen: C0398595 OMIM: 254600 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of myeloperoxidase (MPO) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates myeloperoxidase in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chromatin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    defense response to fungus IEA
    Inferred from Electronic Annotation
    more info
     
    hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hypochlorous acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    low-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of growth of symbiont in host IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
     
    respiratory burst involved in defense response IEA
    Inferred from Electronic Annotation
    more info
     
    response to food IEA
    Inferred from Electronic Annotation
    more info
     
    response to gold nanoparticle IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxidative stress TAS
    Traceable Author Statement
    more info
    PubMed 
    response to yeast IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    azurophil granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    lysosome TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009629.1 RefSeqGene

      Range
      5001..16080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_84

    mRNA and Protein(s)

    1. NM_000250.1NP_000241.1  myeloperoxidase precursor

      See identical proteins and their annotated locations for NP_000241.1

      Status: REVIEWED

      Source sequence(s)
      M19507
      Consensus CDS
      CCDS11604.1
      UniProtKB/Swiss-Prot
      P05164
      Related
      ENSP00000225275.3, OTTHUMP00000260337, ENST00000225275.3, OTTHUMT00000443971
      Conserved Domains (2) summary
      cd09824
      Location:316728
      myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
      pfam03098
      Location:173711
      An_peroxidase; Animal haem peroxidase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      58269856..58280935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      56412238..56423315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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