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    NR4A1 nuclear receptor subfamily 4 group A member 1 [ Homo sapiens (human) ]

    Gene ID: 3164, updated on 8-Oct-2017
    Official Symbol
    NR4A1provided by HGNC
    Official Full Name
    nuclear receptor subfamily 4 group A member 1provided by HGNC
    Primary source
    HGNC:HGNC:7980
    See related
    Ensembl:ENSG00000123358 MIM:139139; Vega:OTTHUMG00000150393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77
    Summary
    This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
    Orthologs
    Location:
    12q13.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (52022832..52059507)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52416616..52453291)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene activin A receptor type 1B Neighboring gene RNA, U6 small nuclear 574, pseudogene Neighboring gene general receptor for phosphoinositides 1 associated scaffold protein Neighboring gene uncharacterized LOC107984510 Neighboring gene autophagy related 101 Neighboring gene olfactory receptor family 7 subfamily E member 47 pseudogene Neighboring gene uncharacterized LOC105369771

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of NR4A1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
    Vpr vpr HIV-1 Vpr downregulates expression of the gene coding for growth factor-inducible nuclear protein N10 in PHA-stimulated PBMC PubMed

    Go to the HIV-1, Human Interaction Database

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      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
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      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC9485

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to corticotropin-releasing hormone stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to fibroblast growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of type B pancreatic cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    nuclear receptor subfamily 4 group A member 1
    Names
    ST-59
    TR3 orphan receptor
    early response protein NAK1
    growth factor-inducible nuclear protein N10
    hormone receptor
    nerve growth factor IB nuclear receptor variant 1
    nuclear hormone receptor NUR/77
    orphan nuclear receptor HMR
    orphan nuclear receptor TR3
    steroid receptor TR3
    testicular receptor 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202233.1NP_001189162.1  nuclear receptor subfamily 4 group A member 1 isoform 2

      See identical proteins and their annotated locations for NP_001189162.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (2) has a shorter N-terminus compared to isoform 3.
      Source sequence(s)
      AC025259, AK297526, BG057763
      Consensus CDS
      CCDS55828.1
      UniProtKB/Swiss-Prot
      P22736
      Related
      ENSP00000353427.3, ENST00000360284.7
      Conserved Domains (2) summary
      cd07348
      Location:374611
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:278352
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    2. NM_001202234.1NP_001189163.1  nuclear receptor subfamily 4 group A member 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC025259, AK131566, BG057763
      Consensus CDS
      CCDS73471.1
      UniProtKB/TrEMBL
      F5GXF0, Q6ZMM6
      Related
      ENSP00000440864.1, OTTHUMP00000241625, ENST00000545748.5, OTTHUMT00000404959
      Conserved Domains (2) summary
      cd07348
      Location:415652
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:319393
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    3. NM_002135.4NP_002126.2  nuclear receptor subfamily 4 group A member 1 isoform 1

      See identical proteins and their annotated locations for NP_002126.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (1) has a shorter N-terminus compared to isoform 3. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC025259, BC016147, BG057763
      Consensus CDS
      CCDS8818.1
      UniProtKB/Swiss-Prot
      P22736
      UniProtKB/TrEMBL
      A0A024R126
      Related
      ENSP00000243050.1, ENST00000243050.5
      Conserved Domains (3) summary
      cd07348
      Location:361598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
      pfam15694
      Location:135230
      Med26_M; Mediator complex subunit 26 middle domain
    4. NM_173157.2NP_775180.1  nuclear receptor subfamily 4 group A member 1 isoform 1

      See identical proteins and their annotated locations for NP_775180.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (1) has a shorter N-terminus compared to isoform 3. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC025259, BG057763, L13740
      Consensus CDS
      CCDS8818.1
      UniProtKB/Swiss-Prot
      P22736
      UniProtKB/TrEMBL
      A0A024R126
      Related
      ENSP00000378302.1, ENST00000394825.5
      Conserved Domains (3) summary
      cd07348
      Location:361598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
      pfam15694
      Location:135230
      Med26_M; Mediator complex subunit 26 middle domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      52022832..52059507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268822.3XP_005268879.1  nuclear receptor subfamily 4 group A member 1 isoform X1

      See identical proteins and their annotated locations for XP_005268879.1

      Conserved Domains (2) summary
      cd07348
      Location:433670
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:337411
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    2. XM_006719364.3XP_006719427.1  nuclear receptor subfamily 4 group A member 1 isoform X3

      See identical proteins and their annotated locations for XP_006719427.1

      UniProtKB/Swiss-Prot
      P22736
      UniProtKB/TrEMBL
      A0A024R126
      Conserved Domains (3) summary
      cd07348
      Location:361598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
      pfam15694
      Location:135230
      Med26_M; Mediator complex subunit 26 middle domain
    3. XM_017019248.1XP_016874737.1  nuclear receptor subfamily 4 group A member 1 isoform X4

    4. XM_017019249.1XP_016874738.1  nuclear receptor subfamily 4 group A member 1 isoform X5

    5. XM_005268824.3XP_005268881.1  nuclear receptor subfamily 4 group A member 1 isoform X3

      See identical proteins and their annotated locations for XP_005268881.1

      UniProtKB/Swiss-Prot
      P22736
      UniProtKB/TrEMBL
      A0A024R126
      Conserved Domains (3) summary
      cd07348
      Location:361598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
      pfam15694
      Location:135230
      Med26_M; Mediator complex subunit 26 middle domain
    6. XM_006719363.1XP_006719426.1  nuclear receptor subfamily 4 group A member 1 isoform X3

      See identical proteins and their annotated locations for XP_006719426.1

      UniProtKB/Swiss-Prot
      P22736
      UniProtKB/TrEMBL
      A0A024R126
      Conserved Domains (3) summary
      cd07348
      Location:361598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
      pfam15694
      Location:135230
      Med26_M; Mediator complex subunit 26 middle domain
    7. XM_017019247.1XP_016874736.1  nuclear receptor subfamily 4 group A member 1 isoform X2

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      52382884..52419560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173158.1: Suppressed sequence

      Description
      NM_173158.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center