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    ZFX zinc finger protein, X-linked [ Homo sapiens (human) ]

    Gene ID: 7543, updated on 8-Apr-2018
    Official Symbol
    ZFXprovided by HGNC
    Official Full Name
    zinc finger protein, X-linkedprovided by HGNC
    Primary source
    HGNC:HGNC:12869
    See related
    Ensembl:ENSG00000005889 MIM:314980; Vega:OTTHUMG00000021264
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF926
    Summary
    This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in endometrium (RPKM 5.2), thyroid (RPKM 4.9) and 25 other tissues See more
    Orthologs
    Location:
    Xp22.11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (24148989..24216255)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (24167047..24234372)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 15 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma Neighboring gene ZFX antisense RNA 1 Neighboring gene SUPT20H like 2 Neighboring gene SUPT20H like 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    zinc finger X-chromosomal protein
    Names
    X-linked zinc finger protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021253.1 RefSeqGene

      Range
      5001..71519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178084.1NP_001171555.1  zinc finger X-chromosomal protein isoform 1

      See identical proteins and their annotated locations for NP_001171555.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons in the 5' UTR, as compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AB209892, AC002404, DA995443, X59739
      Consensus CDS
      CCDS14211.1
      UniProtKB/Swiss-Prot
      P17010
      UniProtKB/TrEMBL
      A0A024RC04, Q59EB9
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001178085.1NP_001171556.1  zinc finger X-chromosomal protein isoform 1

      See identical proteins and their annotated locations for NP_001171556.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an additional exon in the 5' UTR, as compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AB209892, AC002404, M30608, X59740
      Consensus CDS
      CCDS14211.1
      UniProtKB/Swiss-Prot
      P17010
      UniProtKB/TrEMBL
      A0A024RC04, Q59EB9
      Related
      ENSP00000368475.1, OTTHUMP00000023078, ENST00000379177.5, OTTHUMT00000056084
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001178086.1NP_001171557.1  zinc finger X-chromosomal protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks several exons in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AB209892, AC002404, X59738
      Consensus CDS
      CCDS55390.1
      UniProtKB/Swiss-Prot
      P17010
      UniProtKB/TrEMBL
      Q59EB9
      Related
      ENSP00000438233.1, ENST00000539115.5
      Conserved Domains (4) summary
      COG5048
      Location:314438
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam04704
      Location:1181
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      cl19880
      Location:169216
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    4. NM_001178095.1NP_001171566.1  zinc finger X-chromosomal protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two exons in the 5' UTR and has an additional segment in the 3' CDS, as compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AB209892, AC002404
      UniProtKB/TrEMBL
      Q59EB9
      Conserved Domains (1) summary
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    5. NM_001330327.1NP_001317256.1  zinc finger X-chromosomal protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and includes an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
      Source sequence(s)
      AA873535, AB209892, AC002404, BC136309, BP311445, BP374479, DA847701
      Consensus CDS
      CCDS83461.1
      UniProtKB/Swiss-Prot
      P17010
      UniProtKB/TrEMBL
      Q59EB9
    6. NM_003410.3NP_003401.2  zinc finger X-chromosomal protein isoform 1

      See identical proteins and their annotated locations for NP_003401.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variants 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC002404, AF454950, DA848249, M30608
      Consensus CDS
      CCDS14211.1
      UniProtKB/Swiss-Prot
      P17010
      UniProtKB/TrEMBL
      A0A024RC04, Q8WXB7
      Related
      ENSP00000304985.5, OTTHUMP00000023079, ENST00000304543.9, OTTHUMT00000056085
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

      Range
      24148989..24216255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005274592.3XP_005274649.1  zinc finger X-chromosomal protein isoform X3

      See identical proteins and their annotated locations for XP_005274649.1

      UniProtKB/Swiss-Prot
      P17010
      UniProtKB/TrEMBL
      A0A024RC04
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    2. XM_017029799.1XP_016885288.1  zinc finger X-chromosomal protein isoform X6

      Conserved Domains (6) summary
      COG5048
      Location:496633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:443463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:672694
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70357
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:515537
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:380396
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    3. XM_017029792.1XP_016885281.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/Swiss-Prot
      P17010
      Conserved Domains (5) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:601623
      zf-H2C2_2; Zinc-finger double domain
    4. XM_011545581.2XP_011543883.1  zinc finger X-chromosomal protein isoform X3

      See identical proteins and their annotated locations for XP_011543883.1

      UniProtKB/Swiss-Prot
      P17010
      UniProtKB/TrEMBL
      A0A024RC04
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    5. XM_006724513.3XP_006724576.1  zinc finger X-chromosomal protein isoform X1

      See identical proteins and their annotated locations for XP_006724576.1

      UniProtKB/Swiss-Prot
      P17010
      Conserved Domains (5) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:601623
      zf-H2C2_2; Zinc-finger double domain
    6. XM_017029790.1XP_016885279.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/Swiss-Prot
      P17010
      Conserved Domains (5) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:601623
      zf-H2C2_2; Zinc-finger double domain
    7. XM_017029791.2XP_016885280.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/Swiss-Prot
      P17010
      Related
      ENSP00000368486.4, ENST00000379188.7
      Conserved Domains (5) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:601623
      zf-H2C2_2; Zinc-finger double domain
    8. XM_017029800.2XP_016885289.1  zinc finger X-chromosomal protein isoform X7

    9. XM_017029797.2XP_016885286.1  zinc finger X-chromosomal protein isoform X5

      Conserved Domains (5) summary
      COG5048
      Location:518655
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:465485
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:694716
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:45385
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:537559
      zf-H2C2_2; Zinc-finger double domain
    10. XM_005274591.4XP_005274648.1  zinc finger X-chromosomal protein isoform X3

      See identical proteins and their annotated locations for XP_005274648.1

      UniProtKB/Swiss-Prot
      P17010
      UniProtKB/TrEMBL
      A0A024RC04
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    11. XM_017029798.2XP_016885287.1  zinc finger X-chromosomal protein isoform X5

      Conserved Domains (5) summary
      COG5048
      Location:518655
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:465485
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:694716
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:45385
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:537559
      zf-H2C2_2; Zinc-finger double domain
    12. XM_017029794.1XP_016885283.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      P17010
      UniProtKB/TrEMBL
      A0A024RC04
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    13. XM_017029789.1XP_016885278.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/Swiss-Prot
      P17010
      Conserved Domains (5) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:601623
      zf-H2C2_2; Zinc-finger double domain
    14. XM_011545579.1XP_011543881.1  zinc finger X-chromosomal protein isoform X3

      See identical proteins and their annotated locations for XP_011543881.1

      UniProtKB/Swiss-Prot
      P17010
      UniProtKB/TrEMBL
      A0A024RC04
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    15. XM_017029788.1XP_016885277.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/Swiss-Prot
      P17010
      Conserved Domains (5) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:601623
      zf-H2C2_2; Zinc-finger double domain
    16. XM_024452440.1XP_024308208.1  zinc finger X-chromosomal protein isoform X4

      Conserved Domains (5) summary
      COG5048
      Location:535672
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:482502
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:711733
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109396
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:725749
      zf-H2C2_2; Zinc-finger double domain
    17. XM_017029793.1XP_016885282.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/Swiss-Prot
      P17010
      Conserved Domains (5) summary
      COG5048
      Location:582719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:758780
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109449
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:601623
      zf-H2C2_2; Zinc-finger double domain
    18. XM_017029795.1XP_016885284.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      P17010
      UniProtKB/TrEMBL
      A0A024RC04
      Related
      ENSP00000343384.3, OTTHUMP00000023080, ENST00000338565.3, OTTHUMT00000056086
      Conserved Domains (5) summary
      COG5048
      Location:543805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:548570
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:70410
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:562584
      zf-H2C2_2; Zinc-finger double domain
    19. XM_017029796.1XP_016885285.1  zinc finger X-chromosomal protein isoform X4

      Conserved Domains (5) summary
      COG5048
      Location:535672
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:482502
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:711733
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:109396
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:725749
      zf-H2C2_2; Zinc-finger double domain
    20. XM_011545583.3XP_011543885.2  zinc finger X-chromosomal protein isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:554816
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:436458
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:81421
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    21. XM_005274594.5XP_005274651.1  zinc finger X-chromosomal protein isoform X5

      See identical proteins and their annotated locations for XP_005274651.1

      Conserved Domains (5) summary
      COG5048
      Location:518655
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:465485
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:694716
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:45385
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:537559
      zf-H2C2_2; Zinc-finger double domain
    22. XM_017029801.1XP_016885290.1  zinc finger X-chromosomal protein isoform X8

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