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    REG3G regenerating family member 3 gamma [ Homo sapiens (human) ]

    Gene ID: 130120, updated on 25-May-2017
    Official Symbol
    REG3Gprovided by HGNC
    Official Full Name
    regenerating family member 3 gammaprovided by HGNC
    Primary source
    HGNC:HGNC:29595
    See related
    Ensembl:ENSG00000143954 MIM:609933; Vega:OTTHUMG00000130018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAP1B; PAPIB; PAP IB; PAP-1B; UNQ429; LPPM429; REG III; REG-III
    Summary
    This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]
    Orthologs
    Location:
    2p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (79025686..79028504)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (79252812..79255630)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 812, pseudogene Neighboring gene uncharacterized LOC105374822 Neighboring gene regenerating family member 1 beta Neighboring gene regenerating family member 1 alpha

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
    NHGRI GWA Catalog
    • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
      Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup

    Markers

    Homology

    Clone Names

    • MGC118998, MGC118999, MGC119001

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    oligosaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    MyD88-dependent toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    antimicrobial humoral immune response mediated by antimicrobial peptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    antimicrobial humoral response TAS
    Traceable Author Statement
    more info
     
    cell wall disruption in other organism IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytolysis in other organism IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to Gram-positive bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of keratinocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    regenerating islet-derived protein 3-gamma
    Names
    REG-3-gamma
    pancreatitis-associated protein 1B
    pancreatitis-associated protein IB
    reg III-gamma
    regenerating gene III
    regenerating islet-derived 3 gamma
    regenerating islet-derived protein III-gamma

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008387.2NP_001008388.1  regenerating islet-derived protein 3-gamma isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001008388.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AB161038, AK292595, BX280299
      Consensus CDS
      CCDS1962.1
      UniProtKB/Swiss-Prot
      Q6UW15
      Related
      ENSP00000272324.5, OTTHUMP00000202565, ENST00000272324.9, OTTHUMT00000328247
      Conserved Domains (1) summary
      cd03594
      Location:40173
      CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
    2. NM_001270040.1NP_001256969.1  regenerating islet-derived protein 3-gamma isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001256969.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AK292595, BC103852, BX280299
      Consensus CDS
      CCDS58714.1
      UniProtKB/Swiss-Prot
      Q6UW15
      Related
      ENSP00000387105.1, OTTHUMP00000202566, ENST00000409471.1, OTTHUMT00000328248
      Conserved Domains (1) summary
      cl02432
      Location:40127
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    3. NM_198448.3NP_940850.1  regenerating islet-derived protein 3-gamma isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_940850.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK292595, BX280299
      Consensus CDS
      CCDS1962.1
      UniProtKB/Swiss-Prot
      Q6UW15
      Related
      ENSP00000377475.2, OTTHUMP00000160487, ENST00000393897.6, OTTHUMT00000252291
      Conserved Domains (1) summary
      cd03594
      Location:40173
      CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      79025686..79028504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264135.2XP_005264192.1  regenerating islet-derived protein 3-gamma isoform X1

      See identical proteins and their annotated locations for XP_005264192.1

      UniProtKB/Swiss-Prot
      Q6UW15
      Conserved Domains (1) summary
      cd03594
      Location:40173
      CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      79182125..79184941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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