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    GLCCI1 glucocorticoid induced 1 [ Homo sapiens (human) ]

    Gene ID: 113263, updated on 8-Apr-2018
    Official Symbol
    GLCCI1provided by HGNC
    Official Full Name
    glucocorticoid induced 1provided by HGNC
    Primary source
    HGNC:HGNC:18713
    See related
    Ensembl:ENSG00000106415 MIM:614283; Vega:OTTHUMG00000151984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCTR; GIG18; TSSN1; FAM117C
    Summary
    This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. [provided by RefSeq, Feb 2012]
    Expression
    Broad expression in thyroid (RPKM 12.0), testis (RPKM 9.8) and 24 other tissues See more
    Orthologs
    Location:
    7p21.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (7968743..8089080)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (8008374..8128710)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 534, pseudogene Neighboring gene cyclin B2 pseudogene 1 Neighboring gene uncharacterized LOC100505921 Neighboring gene peptidylprolyl isomerase like 4 pseudogene Neighboring gene uncharacterized LOC105375142 Neighboring gene islet cell autoantigen 1 Neighboring gene uncharacterized LOC100505938

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Glucocorticoid therapy, response to
    MedGen: C3280689 OMIM: 614400 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus.
    NHGRI GWA Catalog
    Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: UMAD1

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    glucocorticoid-induced transcript 1 protein
    Names
    glucocorticoid induced transcript 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032073.1 RefSeqGene

      Range
      5001..125337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138426.3NP_612435.1  glucocorticoid-induced transcript 1 protein

      See identical proteins and their annotated locations for NP_612435.1

      Status: REVIEWED

      Source sequence(s)
      AL832860, AL833694, BC050291, DB059656
      Consensus CDS
      CCDS34601.1
      UniProtKB/Swiss-Prot
      Q86VQ1
      Related
      ENSP00000223145.5, OTTHUMP00000200889, ENST00000223145.9, OTTHUMT00000324672
      Conserved Domains (1) summary
      pfam15388
      Location:167477
      FAM117; Protein Family FAM117

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      7968743..8089080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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