Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    EIF4G1 eukaryotic translation initiation factor 4 gamma 1 [ Homo sapiens (human) ]

    Gene ID: 1981, updated on 23-May-2018
    Official Symbol
    EIF4G1provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4 gamma 1provided by HGNC
    Primary source
    HGNC:HGNC:3296
    See related
    Ensembl:ENSG00000114867 MIM:600495; Vega:OTTHUMG00000156784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1
    Summary
    The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in esophagus (RPKM 48.2), skin (RPKM 39.4) and 25 other tissues See more
    Orthologs
    See EIF4G1 in Genome Data Viewer
    Location:
    3q27.1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (184314495..184335358)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (184032283..184053146)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene EEF1AKMT4-ECE2 readthrough Neighboring gene endothelin converting enzyme 2 Neighboring gene proteasome 26S subunit, non-ATPase 2 Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene family with sequence similarity 131 member A Neighboring gene chloride voltage-gated channel 2 Neighboring gene RNA polymerase II subunit H

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Parkinson disease 18
    MedGen: C3280271 OMIM: 614251 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of EIF4G1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated eukaryotic translation initiation factor 4 gamma, 1 (EIF4G1) protein is incorporated into HIV-1 Gag virus-like particles PubMed
    gag The initiation factor eIF4G is required for the synthesis of the Gag polyprotein by a classical cap-dependent mechanism PubMed
    Tat tat HIV-1 Tat co-localizes with eIF4G in cytoplasmic stress granules under stress conditions PubMed
    retropepsin gag-pol Purified HIV-1 protease cleaves eIF4GI at positions 678, 681, and 1086 leading to inhibition of protein synthesis directed by capped mRNAs PubMed

    Go to the HIV-1, Human Interaction Database

    • AUF1 (hnRNP D0) binds and destabilizes mRNA, organism-specific biosystem (from REACTOME)
      AUF1 (hnRNP D0) binds and destabilizes mRNA, organism-specific biosystemAUF1 (hnRNP D0) dimers bind U-rich regions of AU-rich elements (AREs) in the 3' untranslated regions of mRNAs. The binding causes AUF1 dimers to assemble into higher order tetrameric complexes. Dipho...
    • Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem (from REACTOME)
      Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystemThe cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF...
    • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
      Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
    • Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
      Cap-dependent Translation Initiation, organism-specific biosystemTranslation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start c...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Deadenylation of mRNA, organism-specific biosystem (from REACTOME)
      Deadenylation of mRNA, organism-specific biosystemDeadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 compl...
    • Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
      Deadenylation-dependent mRNA decay, organism-specific biosystemAfter undergoing rounds of translation, mRNA is normally destroyed by the deadenylation-dependent pathway. Though the trigger is unclear, deadenylation likely proceeds in two steps: one catalyzed by...
    • Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
      Eukaryotic Translation Initiation, organism-specific biosystemInitiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG sta...
    • GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
      GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemHydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
      IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
    • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
      IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
    • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
      IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
    • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
      ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
      Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
      L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemWhile circularization of mRNA during translation initiation is thought to contribute to an increase in the efficiency of translation, it also appears to provide a mechanism for translational silencin...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
      Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystemDuring normal translation termination eRF3 associates with the ribosome and then interacts with PABP bound to the polyadenylate tail of the mRNA to release the ribosome and allow a new round of trans...
    • Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
      Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystemNonsense-mediated decay has been observed with mRNAs that do not have an exon junction complex (EJC) downstream of the termination codon (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-An...
    • Nonsense-Mediated Decay (NMD), organism-specific biosystem (from REACTOME)
      Nonsense-Mediated Decay (NMD), organism-specific biosystemThe Nonsense-Mediated Decay (NMD) pathway activates the destruction of mRNAs containing premature termination codons (PTCs) (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-Ansmant et al. ...
    • PI3K Cascade, organism-specific biosystem (from REACTOME)
      PI3K Cascade, organism-specific biosystem
      PI3K Cascade
    • PKB-mediated events, organism-specific biosystem (from REACTOME)
      PKB-mediated events, organism-specific biosystemPKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystem (from REACTOME)
      Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystemRNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-eleme...
    • Ribosomal scanning and start codon recognition, organism-specific biosystem (from REACTOME)
      Ribosomal scanning and start codon recognition, organism-specific biosystemThe 80S ribosome bound to the mRNA moves along the mRNA molecule from its initial site to the initiation codon and forms a 48S complex, in which the initiation codon is base paired to the anticodon o...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
      Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
    • Translation, organism-specific biosystem (from REACTOME)
      Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
    • Translation initiation complex formation, organism-specific biosystem (from REACTOME)
      Translation initiation complex formation, organism-specific biosystemThe translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. e...
    • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional activation, organism-specific biosystem
      Validated targets of C-MYC transcriptional activation
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    • eIF4F complex, organism-specific biosystem (from KEGG)
      eIF4F complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • eIF4F complex, conserved biosystem (from KEGG)
      eIF4F complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
    • mTOR signalling, organism-specific biosystem (from REACTOME)
      mTOR signalling, organism-specific biosystemTarget of rapamycin (mTOR) is a highly-conserved serine/threonine kinase that regulates cell growth and division in response to energy levels, growth signals, and nutrients (Zoncu et al. 2011). Contr...
    • mTORC1-mediated signalling, organism-specific biosystem (from REACTOME)
      mTORC1-mediated signalling, organism-specific biosystemmTORC1 integrates four major signals ? growth factors, energy status, oxygen and amino acids ? to regulate many processes that are involved in the promotion of cell growth. Growth factors stimulate m...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp686A1451

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding HDA PubMed 
    RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    eukaryotic initiation factor 4E binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eukaryotic initiation factor 4E binding TAS
    Traceable Author Statement
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex scaffold activity TAS
    Traceable Author Statement
    more info
    PubMed 
    translation factor activity, RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation initiation factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    translation initiation factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    cap-dependent translational initiation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular macromolecule biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to nutrient levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    developmental process TAS
    Traceable Author Statement
    more info
    PubMed 
    energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron death TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
    Traceable Author Statement
    more info
     
    positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cellular protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of eukaryotic translation initiation factor 4F complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mRNA cap binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of miRNA mediated inhibition of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cellular response to stress TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of gene silencing by miRNA TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of mRNA stability TAS
    Traceable Author Statement
    more info
     
    regulation of polysome binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of presynapse assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of translational initiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translation IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translational initiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    translational initiation TAS
    Traceable Author Statement
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with cytosolic small ribosomal subunit TAS
    Traceable Author Statement
    more info
    PubMed 
    eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic translation initiation factor 4F complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane HDA PubMed 
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    polysome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Preferred Names
    eukaryotic translation initiation factor 4 gamma 1
    Names
    EIF4-gamma
    eIF-4-gamma 1
    eucaryotic translation initiation factor 4G

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016850.1 RefSeqGene

      Range
      4928..25791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001194946.1NP_001181875.1  eukaryotic translation initiation factor 4 gamma 1 isoform 6

      See identical proteins and their annotated locations for NP_001181875.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, includes an additional in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (6) is longer than isoform 1. Both variants 6 and 7 encode the same isoform.
      Source sequence(s)
      BC140892, BC140896, BQ011010, CR980540
      Consensus CDS
      CCDS54687.1
      UniProtKB/TrEMBL
      B2RU06, B2RU10
      Related
      ENSP00000371767.3, OTTHUMP00000210589, ENST00000382330.7, OTTHUMT00000345740
      Conserved Domains (5) summary
      cd11559
      Location:14451577
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam09606
      Location:24459
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02847
      Location:12491361
      MA3; MA3 domain
      pfam02854
      Location:768993
      MIF4G; MIF4G domain
      pfam08648
      Location:11541255
      DUF1777; Protein of unknown function (DUF1777)
    2. NM_001194947.1NP_001181876.1  eukaryotic translation initiation factor 4 gamma 1 isoform 6

      See identical proteins and their annotated locations for NP_001181876.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, includes an additional in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (6) is longer than isoform 1. Both variants 6 and 7 encode the same isoform.
      Source sequence(s)
      BC140896, BQ011010, CR980540
      Consensus CDS
      CCDS54687.1
      UniProtKB/TrEMBL
      B2RU10
      Related
      ENSP00000338020.4, ENST00000352767.7
      Conserved Domains (5) summary
      cd11559
      Location:14451577
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam09606
      Location:24459
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02847
      Location:12491361
      MA3; MA3 domain
      pfam02854
      Location:768993
      MIF4G; MIF4G domain
      pfam08648
      Location:11541255
      DUF1777; Protein of unknown function (DUF1777)
    3. NM_001291157.1NP_001278086.1  eukaryotic translation initiation factor 4 gamma 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, includes an additional internal segment in the 5' region, which results in a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (7) is shorter at the N-terminus, and lacks an internal residue, compared to isoform 1.
      Source sequence(s)
      AK226160, BG177454, DC369776
      Consensus CDS
      CCDS77866.1
      Related
      ENSP00000391935.1, OTTHUMP00000210586, ENST00000414031.5, OTTHUMT00000345736
      Conserved Domains (4) summary
      cd11559
      Location:13981530
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12021314
      MA3; MA3 domain
      pfam02854
      Location:721946
      MIF4G; MIF4G domain
      pfam08648
      Location:11071208
      DUF1777; Protein of unknown function (DUF1777)
    4. NM_004953.4NP_004944.3  eukaryotic translation initiation factor 4 gamma 1 isoform 4

      See identical proteins and their annotated locations for NP_004944.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC078797, BQ011010
      Consensus CDS
      CCDS46970.2
      UniProtKB/Swiss-Prot
      Q04637
      Related
      ENSP00000411826.2, OTTHUMP00000233293, ENST00000434061.6, OTTHUMT00000345742
      Conserved Domains (4) summary
      cd11559
      Location:12431375
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:10471159
      MA3; MA3 domain
      pfam02854
      Location:566791
      MIF4G; MIF4G domain
      pfam08648
      Location:9521053
      DUF1777; Protein of unknown function (DUF1777)
    5. NM_182917.4NP_886553.3  eukaryotic translation initiation factor 4 gamma 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AF002815, AK308319, AY082886, BQ011010, DC347118
      Consensus CDS
      CCDS54688.1
      UniProtKB/Swiss-Prot
      Q04637
      UniProtKB/TrEMBL
      O95065
      Related
      ENSP00000343450.4, OTTHUMP00000210577, ENST00000342981.8, OTTHUMT00000345727
      Conserved Domains (4) summary
      cd11559
      Location:14391571
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12431355
      MA3; MA3 domain
      pfam02854
      Location:762987
      MIF4G; MIF4G domain
      pfam08648
      Location:11481249
      DUF1777; Protein of unknown function (DUF1777)
    6. NM_198241.2NP_937884.1  eukaryotic translation initiation factor 4 gamma 1 isoform 5

      See identical proteins and their annotated locations for NP_937884.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (5) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      BC007788, BQ011010, BX647812, CR980540
      Consensus CDS
      CCDS3259.1
      UniProtKB/Swiss-Prot
      Q04637
      UniProtKB/TrEMBL
      Q96I65
      Related
      ENSP00000316879.4, OTTHUMP00000210583, ENST00000346169.6, OTTHUMT00000345733
      Conserved Domains (4) summary
      cd11559
      Location:14381570
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12421354
      MA3; MA3 domain
      pfam02854
      Location:761986
      MIF4G; MIF4G domain
      pfam08648
      Location:11471248
      DUF1777; Protein of unknown function (DUF1777)
    7. NM_198242.2NP_937885.1  eukaryotic translation initiation factor 4 gamma 1 isoform 3

      See identical proteins and their annotated locations for NP_937885.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an internal residue, compared to isoform 1.
      Source sequence(s)
      AL832754, BM475154, BQ011010, CR980540, CX165113
      Consensus CDS
      CCDS3261.1
      UniProtKB/Swiss-Prot
      Q04637
      Related
      ENSP00000317600.8, OTTHUMP00000210585, ENST00000350481.9, OTTHUMT00000345735
      Conserved Domains (4) summary
      cd11559
      Location:12741406
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:10781190
      MA3; MA3 domain
      pfam02854
      Location:597822
      MIF4G; MIF4G domain
      pfam08648
      Location:9831084
      DUF1777; Protein of unknown function (DUF1777)
    8. NM_198244.2NP_937887.1  eukaryotic translation initiation factor 4 gamma 1 isoform 2

      See identical proteins and their annotated locations for NP_937887.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an internal residue, compared to isoform 1.
      Source sequence(s)
      AK299763, BC007788, BC010688, BQ011010, CR980540
      Consensus CDS
      CCDS3260.1
      UniProtKB/TrEMBL
      B4DSI9, Q96I65
      Related
      ENSP00000376320.2, OTTHUMP00000210579, ENST00000392537.6, OTTHUMT00000345729
      Conserved Domains (4) summary
      cd11559
      Location:13511483
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:11551267
      MA3; MA3 domain
      pfam02854
      Location:674899
      MIF4G; MIF4G domain
      pfam08648
      Location:10601161
      DUF1777; Protein of unknown function (DUF1777)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      184314495..184335358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center