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    TAF3 TATA-box binding protein associated factor 3 [ Homo sapiens (human) ]

    Gene ID: 83860, updated on 5-Nov-2017
    Official Symbol
    TAF3provided by HGNC
    Official Full Name
    TATA-box binding protein associated factor 3provided by HGNC
    Primary source
    HGNC:HGNC:17303
    See related
    Ensembl:ENSG00000165632 MIM:606576; Vega:OTTHUMG00000017643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAF140; TAFII140; TAFII-140
    Summary
    The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]
    Expression
    Ubiquitous expression in testis (RPKM 5.8), ovary (RPKM 3.8) and 25 other tissues See more
    Orthologs
    Location:
    10p14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (7818477..8016631)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (7860467..8057016)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene uncharacterized LOC105376392 Neighboring gene ATP synthase F1 subunit gamma Neighboring gene uncharacterized LOC105376394 Neighboring gene GATA3 antisense RNA 1 Neighboring gene GATA binding protein 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
    tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
    tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
    tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
    tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC25063

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    transcription initiation factor TFIID subunit 3
    Names
    140 kDa TATA box-binding protein-associated factor
    RNA polymerase II transcription factor TAFII140
    TAF(II)140
    TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
    TBP-associated factor 3
    transcription initiation factor TFIID 140 kDa subunit

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031923.3NP_114129.1  transcription initiation factor TFIID subunit 3

      See identical proteins and their annotated locations for NP_114129.1

      Status: VALIDATED

      Source sequence(s)
      AL159172, AL353754, AL390294
      Consensus CDS
      CCDS41487.1
      UniProtKB/Swiss-Prot
      Q5VWG9
      Related
      ENSP00000340271.5, OTTHUMP00000019072, ENST00000344293.5, OTTHUMT00000046725
      Conserved Domains (2) summary
      smart00576
      Location:579
      BTP; Bromodomain transcription factors and PHD domain containing proteins
      cd15522
      Location:867912
      PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      7818477..8016631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519741.1XP_011518043.1  transcription initiation factor TFIID subunit 3 isoform X1

      Conserved Domains (2) summary
      smart00576
      Location:82156
      BTP; Bromodomain transcription factors and PHD domain containing proteins
      cd15522
      Location:943988
      PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      7860425..8057017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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