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    CDC42 cell division cycle 42 [ Homo sapiens (human) ]

    Gene ID: 998, updated on 23-Apr-2017
    Official Symbol
    CDC42provided by HGNC
    Official Full Name
    cell division cycle 42provided by HGNC
    Primary source
    HGNC:HGNC:1736
    See related
    Ensembl:ENSG00000070831 MIM:116952; Vega:OTTHUMG00000002753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TKS; G25K; CDC42Hs
    Summary
    The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
    Orthologs
    Location:
    1p36.12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (22052627..22092943)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (22379120..22419439)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chymotrypsin like elastase family member 3A Neighboring gene RNA, 7SL, cytoplasmic 186, pseudogene Neighboring gene long intergenic non-protein coding RNA 1635 Neighboring gene long intergenic non-protein coding RNA 339 Neighboring gene M-phase phosphoprotein 6 pseudogene Neighboring gene Wnt family member 4 Neighboring gene uncharacterized LOC105376845 Neighboring gene uncharacterized LOC105376850

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Takenouchi-Kosaki syndrome
    MedGen: CN234779 OMIM: 616737 GeneReviews: Not available
    not available

    NHGRI GWAS Catalog

    Description
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
    env DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface subsequently activates Cdc42, Pak1, and Wasp, leading to an increase in membrane extensions at the DC surface PubMed
    Nef nef HIV-1 Nef enhances the expression of CDC42 in human podocyte PubMed
    nef The activation of Nef-associated kinase (NAK; also known as p21-activated kinase 1 or PAK1) by HIV-1 Nef is via the small GTPases Cdc42 and Rac1, suggesting an interaction between Nef and these GTPases PubMed
    nef HIV-1 Nef inhibits the concomitant activation of the actin organizer N-Wasp by interfering with the translocation of N-Wasp to the cell periphery and blocks morphological changes induced by the known N-Wasp regulators Rac1 and Cdc42 PubMed
    nef HIV-1 Nef treatment upregulates active CDC42 levels in dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

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      RalA downstream regulated genes, organism-specific biosystemDownstream genes of RalA signaling pathways, including the Rac-family GTPase-activating protein RLIP (also known as RLIP76 and ralA binding protein 1 (RALBP1)), CDC42(cell division cycle 42), RAC1 (r...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
    • Regulation of CDC42 activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of CDC42 activity, organism-specific biosystem
      Regulation of CDC42 activity
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
      Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RhoA signaling pathway, organism-specific biosystem
      RhoA signaling pathway
    • S1P4 pathway, organism-specific biosystem (from Pathway Interaction Database)
      S1P4 pathway, organism-specific biosystem
      S1P4 pathway
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
      Sema4D in semaphorin signaling, organism-specific biosystemSemaphorin 4D (Sema 4D/CD100) is an axon guidance molecule with two disulfide-linked 150-kDa subunits. SEMA4D is structurally defined by a conserved 500-amino acid extracellular domain with 16 cyste...
    • Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
      Sema4D induced cell migration and growth-cone collapse, organism-specific biosystemSema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates ML...
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
    • Shigellosis, organism-specific biosystem (from KEGG)
      Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
      Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
    • Target Of Rapamycin (TOR) Signaling, organism-specific biosystem (from WikiPathways)
      Target Of Rapamycin (TOR) Signaling, organism-specific biosystemTOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central r...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GBD domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Rho GDP-dissociation inhibitor binding IEA
    Inferred from Electronic Annotation
    more info
     
    apolipoprotein A-I receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mitogen-activated protein kinase kinase kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thioesterase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Cdc42 protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell costimulation TAS
    Traceable Author Statement
    more info
     
    Wnt signaling pathway, planar cell polarity pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament branching IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
     
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac conduction system development IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    epithelial cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial-mesenchymal cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of Golgi localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    establishment or maintenance of apical/basal cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    establishment or maintenance of cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle placode formation IEA
    Inferred from Electronic Annotation
    more info
     
    heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    keratinization IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    macrophage differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    modification of synaptic structure IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein complex assembly IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    neuron fate determination IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear migration IEA
    Inferred from Electronic Annotation
    more info
     
    organelle transport along microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell proliferation involved in lung morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hair follicle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of muscle cell differentiation TAS
    Traceable Author Statement
    more info
     
    positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of pseudopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of synapse structural plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of lamellipodium assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    regulation of stress fiber assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    submandibular salivary gland formation IEA
    Inferred from Electronic Annotation
    more info
     
    substantia nigra development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    viral RNA genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Golgi transport complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leading edge membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    storage vacuole IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cell division control protein 42 homolog
    Names
    G25K GTP-binding protein
    GTP binding protein, 25kDa
    dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
    dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
    growth-regulating protein
    small GTP binding protein CDC42

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047042.1 RefSeqGene

      Range
      5001..45317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001039802.1NP_001034891.1  cell division control protein 42 homolog isoform 1 precursor

      See identical proteins and their annotated locations for NP_001034891.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an additional exon in the 5' UTR and encodes the same isoform 1, compared to variant 1.
      Source sequence(s)
      AL031281, BC018266, BP871988
      Consensus CDS
      CCDS221.1
      UniProtKB/Swiss-Prot
      P60953
      UniProtKB/TrEMBL
      A0A024RAE4
      Related
      ENSP00000341072.3, OTTHUMP00000002834, ENST00000344548.7, OTTHUMT00000007787
      Conserved Domains (2) summary
      smart00174
      Location:6179
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    2. NM_001791.3NP_001782.1  cell division control protein 42 homolog isoform 1 precursor

      See identical proteins and their annotated locations for NP_001782.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1 which has the same aa length but different C-terminus from isoform 2.
      Source sequence(s)
      AL031281, BC018266, BP871988
      Consensus CDS
      CCDS221.1
      UniProtKB/Swiss-Prot
      P60953
      UniProtKB/TrEMBL
      A0A024RAE4
      Related
      ENSP00000383118.1, ENST00000400259.5
      Conserved Domains (2) summary
      smart00174
      Location:6179
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    3. NM_044472.2NP_426359.1  cell division control protein 42 homolog isoform 2

      See identical proteins and their annotated locations for NP_426359.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs from variant 1 at the 3' region including a small part of the coding region and the entire 3' UTR. This variant encodes isoform 2 which has the same aa length but different C-terminus from isoform 1.
      Source sequence(s)
      AL031281, BM684474, BP871988
      Consensus CDS
      CCDS222.1
      UniProtKB/Swiss-Prot
      P60953
      UniProtKB/TrEMBL
      A0A024RAE6
      Related
      ENSP00000314458.8, OTTHUMP00000002926, ENST00000315554.12, OTTHUMT00000008075
      Conserved Domains (2) summary
      smart00174
      Location:6179
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      22052627..22092943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      22491651..22531931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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