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    DICER1 dicer 1, ribonuclease III [ Homo sapiens (human) ]

    Gene ID: 23405, updated on 20-Feb-2017
    Official Symbol
    DICER1provided by HGNC
    Official Full Name
    dicer 1, ribonuclease IIIprovided by HGNC
    Primary source
    HGNC:HGNC:17098
    See related
    Ensembl:ENSG00000100697 MIM:606241; Vega:OTTHUMG00000166134
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCR1; MNG1; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
    Summary
    This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
    Orthologs
    Location:
    14q32.13
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (95086228..95158010, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95552565..95623759, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984637 Neighboring gene uncharacterized LOC107984646 Neighboring gene microRNA 3173 Neighboring gene DICER1 antisense RNA 1 Neighboring gene calmin Neighboring gene uncharacterized LOC105370637

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
    NHGRI GWA Catalog
    Genome-wide association of lipid-lowering response to statins in combined study populations.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of dicer 1, ribonuclease type III (DICER1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Knockdown of Dicer by shRNA leads to inhibit enrichment of HIV-1 Gag in intracellular vacuoles, but enhance viral particle release in Gag expressing cells PubMed
    gag Interaction of HIV-1 Gag with dicer 1, ribonuclease type III (DICER1) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    Rev rev The arginine rich motif (residues 35-50) of HIV-1 Rev inhibits Dicer dependent RNAi process PubMed
    Tat tat The arginine rich motif (residues 48-58) of HIV-1 Tat inhibits Dicer dependent RNAi process PubMed
    tat HIV-1 Tat-Dicer interaction requires RNA; Dicer's helicase domain (residues 246-585) and a portion of Tat amino acids 30-72 are involved in the interaction PubMed
    Vpr vpr HIV-1 Vpr-induced downregulation of Dicer is not dependent on G2 cell cycle arrest but on the Cul4A-DCAF1-DDB1 ubiquitin ligase complex PubMed
    vpr HIV-1 Vpr complexes with Dicer and induces downregulation of Dicer in HIV-1 infected cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Gene Silencing by RNA, organism-specific biosystem (from REACTOME)
      Gene Silencing by RNA, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
    • Hypoxia-mediated EMT and Stemness, organism-specific biosystem (from WikiPathways)
      Hypoxia-mediated EMT and Stemness, organism-specific biosystemModel of hypoxia mediated EMT and stemness.
    • MicroRNA (miRNA) biogenesis, organism-specific biosystem (from REACTOME)
      MicroRNA (miRNA) biogenesis, organism-specific biosystemBiogenesis of microRNAs (miRNAs) can be summarized in five steps (reviewed in Ketting 2011, Nowotny and Yang 2009, Kim et al. 2009, Chua et al. 2009, Hannon and He 2004):1. Transcription. miRNA trans...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • RNA interference, organism-specific biosystem (from WikiPathways)
      RNA interference, organism-specific biosystemThe process of RNA-interference in eukaryotic cells. Long precursor microRNA (miRNA), called pri-miRNA, is cleaved by RNase III endonuclease (Drosha) into pieces of approximately 70 nucleotides each ...
    • Small interfering RNA (siRNA) biogenesis, organism-specific biosystem (from REACTOME)
      Small interfering RNA (siRNA) biogenesis, organism-specific biosystemSmall interfering RNAs (siRNAs) are 21-25 nucleotide single-stranded RNAs produced by cleavage of longer double-stranded RNAs by the enzyme DICER1 within the RISC loading complex containing DICER1, a...
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • miRNA Biogenesis, organism-specific biosystem (from WikiPathways)
      miRNA Biogenesis, organism-specific biosystemmicroRNA biogenesis + an example of a miRBase entry. As an example immature hsa-mir-146a is shown
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0928

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoribonuclease activity TAS
    Traceable Author Statement
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    pre-miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to pre-miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribonuclease III activity EXP
    Inferred from Experiment
    more info
    PubMed 
    ribonuclease III activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    siRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA phosphodiester bond hydrolysis, endonucleolytic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    conversion of ds siRNA to ss siRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    conversion of ds siRNA to ss siRNA involved in RNA interference IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gene silencing by RNA TAS
    Traceable Author Statement
    more info
     
    miRNA loading onto RISC involved in gene silencing by miRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of Schwann cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nerve development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peripheral nervous system myelin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of Schwann cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    production of miRNAs involved in gene silencing by miRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    production of miRNAs involved in gene silencing by miRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    production of siRNA involved in RNA interference IDA
    Inferred from Direct Assay
    more info
    PubMed 
    siRNA loading onto RISC involved in RNA interference IDA
    Inferred from Direct Assay
    more info
    PubMed 
    targeting of mRNA for destruction involved in RNA interference IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    ARC complex IC
    Inferred by Curator
    more info
    PubMed 
    NOT RISC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RISC-loading complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    endoribonuclease Dicer
    Names
    Dicer1, Dcr-1 homolog
    dicer 1, double-stranded RNA-specific endoribonuclease
    dicer 1, ribonuclease type III
    helicase MOI
    helicase with RNAse motif
    NP_001182502.1
    NP_001258211.1
    NP_001278557.1
    NP_085124.2
    NP_803187.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016311.1 RefSeqGene

      Range
      4413..76195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_492

    mRNA and Protein(s)

    1. NM_001195573.1NP_001182502.1  endoribonuclease Dicer isoform 2

      See identical proteins and their annotated locations for NP_001182502.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 2. The resulting isoform 2 (also called t-Dicer) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL356017, AL390254, HM595745
      Consensus CDS
      CCDS55941.1
      UniProtKB/Swiss-Prot
      Q9UPY3
      Related
      ENSP00000444719, OTTHUMP00000274912, ENST00000541352, OTTHUMT00000474215
      Conserved Domains (10) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      smart00487
      Location:40242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16661765
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:16821767
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631714
      Dicer_dimer; Dicer dimerization domain
    2. NM_001271282.2NP_001258211.1  endoribonuclease Dicer isoform 1

      See identical proteins and their annotated locations for NP_001258211.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AF007142, AJ132261, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      Q9UPY3
      Related
      ENSP00000435681, OTTHUMP00000231972, ENST00000527414, OTTHUMT00000387999
      Conserved Domains (11) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      smart00358
      Location:18501913
      DSRM; Double-stranded RNA binding motif
      smart00487
      Location:40242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:16821846
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631714
      Dicer_dimer; Dicer dimerization domain
    3. NM_001291628.1NP_001278557.1  endoribonuclease Dicer isoform 1

      See identical proteins and their annotated locations for NP_001278557.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AF007142, AJ132261, AL390254, AY845868, BM152875
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      Q9UPY3
      Conserved Domains (11) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      smart00358
      Location:18501913
      DSRM; Double-stranded RNA binding motif
      smart00487
      Location:40242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:16821846
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631714
      Dicer_dimer; Dicer dimerization domain
    4. NM_030621.4NP_085124.2  endoribonuclease Dicer isoform 1

      See identical proteins and their annotated locations for NP_085124.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AF007142, AJ132261, AL390254, AY845867, BM152875
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      Q9UPY3
      Related
      ENSP00000437256, OTTHUMP00000231971, ENST00000526495, OTTHUMT00000387997
      Conserved Domains (11) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      smart00358
      Location:18501913
      DSRM; Double-stranded RNA binding motif
      smart00487
      Location:40242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:16821846
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631714
      Dicer_dimer; Dicer dimerization domain
    5. NM_177438.2NP_803187.1  endoribonuclease Dicer isoform 1

      See identical proteins and their annotated locations for NP_803187.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AF007142, AL390254, BC150287
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      Q9UPY3
      Related
      ENSP00000343745, OTTHUMP00000231970, ENST00000343455, OTTHUMT00000387996
      Conserved Domains (11) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      smart00358
      Location:18501913
      DSRM; Double-stranded RNA binding motif
      smart00487
      Location:40242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:16821846
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631714
      Dicer_dimer; Dicer dimerization domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      95086228..95158010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536600.2XP_011534902.1  endoribonuclease Dicer isoform X1

      See identical proteins and their annotated locations for XP_011534902.1

      UniProtKB/Swiss-Prot
      Q9UPY3
      Conserved Domains (11) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      smart00358
      Location:18501913
      DSRM; Double-stranded RNA binding motif
      smart00487
      Location:40242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:16821846
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631714
      Dicer_dimer; Dicer dimerization domain
    2. XM_017021121.1XP_016876610.1  endoribonuclease Dicer isoform X1

      UniProtKB/Swiss-Prot
      Q9UPY3
      Conserved Domains (11) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      smart00358
      Location:18501913
      DSRM; Double-stranded RNA binding motif
      smart00487
      Location:40242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:16821846
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631714
      Dicer_dimer; Dicer dimerization domain
    3. XM_011536599.1XP_011534901.1  endoribonuclease Dicer isoform X1

      See identical proteins and their annotated locations for XP_011534901.1

      UniProtKB/Swiss-Prot
      Q9UPY3
      Conserved Domains (11) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      smart00358
      Location:18501913
      DSRM; Double-stranded RNA binding motif
      smart00487
      Location:40242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:16821846
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631714
      Dicer_dimer; Dicer dimerization domain
    4. XM_011536601.2XP_011534903.1  endoribonuclease Dicer isoform X1

      See identical proteins and their annotated locations for XP_011534903.1

      UniProtKB/Swiss-Prot
      Q9UPY3
      Conserved Domains (11) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      smart00358
      Location:18501913
      DSRM; Double-stranded RNA binding motif
      smart00487
      Location:40242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:16821846
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631714
      Dicer_dimer; Dicer dimerization domain
    5. XM_011536602.2XP_011534904.1  endoribonuclease Dicer isoform X1

      See identical proteins and their annotated locations for XP_011534904.1

      UniProtKB/Swiss-Prot
      Q9UPY3
      Conserved Domains (11) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      smart00358
      Location:18501913
      DSRM; Double-stranded RNA binding motif
      smart00487
      Location:40242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:16821846
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631714
      Dicer_dimer; Dicer dimerization domain
    6. XM_017021120.1XP_016876609.1  endoribonuclease Dicer isoform X1

      UniProtKB/Swiss-Prot
      Q9UPY3
      Conserved Domains (11) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      smart00358
      Location:18501913
      DSRM; Double-stranded RNA binding motif
      smart00487
      Location:40242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:16821846
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631714
      Dicer_dimer; Dicer dimerization domain
    7. XM_017021123.1XP_016876612.1  endoribonuclease Dicer isoform X2

      Conserved Domains (9) summary
      smart00535
      Location:11611252
      RIBOc; Ribonuclease III family
      smart00358
      Location:17151778
      DSRM; Double-stranded RNA binding motif
      COG0571
      Location:15311783
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:1274
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:15471711
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:751873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:136230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:310418
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:496579
      Dicer_dimer; Dicer dimerization domain
    8. XM_011536604.2XP_011534906.1  endoribonuclease Dicer isoform X2

      Conserved Domains (9) summary
      smart00535
      Location:11611252
      RIBOc; Ribonuclease III family
      smart00358
      Location:17151778
      DSRM; Double-stranded RNA binding motif
      COG0571
      Location:15311783
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:1274
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:15471711
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:751873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:136230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:310418
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:496579
      Dicer_dimer; Dicer dimerization domain
    9. XM_011536605.2XP_011534907.1  endoribonuclease Dicer isoform X3

      Conserved Domains (7) summary
      smart00535
      Location:803894
      RIBOc; Ribonuclease III family
      smart00358
      Location:13571420
      DSRM; Double-stranded RNA binding motif
      COG0571
      Location:11731425
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00593
      Location:11891353
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:393515
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      pfam00271
      Location:860
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:138221
      Dicer_dimer; Dicer dimerization domain
    10. XM_017021122.1XP_016876611.1  endoribonuclease Dicer isoform X2

      Conserved Domains (9) summary
      smart00535
      Location:11611252
      RIBOc; Ribonuclease III family
      smart00358
      Location:17151778
      DSRM; Double-stranded RNA binding motif
      COG0571
      Location:15311783
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:1274
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:15471711
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:751873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:136230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:310418
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:496579
      Dicer_dimer; Dicer dimerization domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      95490915..95562577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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