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    HGF hepatocyte growth factor [ Homo sapiens (human) ]

    Gene ID: 3082, updated on 23-Jul-2017
    Official Symbol
    HGFprovided by HGNC
    Official Full Name
    hepatocyte growth factorprovided by HGNC
    Primary source
    HGNC:HGNC:4893
    See related
    Ensembl:ENSG00000019991 MIM:142409; Vega:OTTHUMG00000023804
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SF; HGFB; HPTA; F-TCF; DFNB39
    Summary
    This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
    Orthologs
    Location:
    7q21.11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (81699006..81770438, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (81331444..81399452, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369146 Neighboring gene uncharacterized LOC100128317 Neighboring gene DEAD-box helicase 43 pseudogene 3 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene uncharacterized LOC101927356 Neighboring gene uncharacterized LOC107986813

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Scatter factor (SF) attenuates the apoptosis induced by high-doses of HIV-1 gp120 in human mesangial cells (HMC) PubMed
    Vpu vpu The gene expression of hepatocyte growth factor (HGF) increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates HGF protein expression PubMed

    Go to the HIV-1, Human Interaction Database

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    • Immune System, organism-specific biosystem (from REACTOME)
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    • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
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    • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
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    • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
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    • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
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    • MAPK1/MAPK3 signaling, organism-specific biosystem (from REACTOME)
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    • MET Receptor Activation, organism-specific biosystem (from REACTOME)
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    • MET activates PTPN11, organism-specific biosystem (from REACTOME)
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    • MET activates STAT3, organism-specific biosystem (from REACTOME)
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    • Rap1 signaling pathway, conserved biosystem (from KEGG)
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    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
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    • Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
      Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemThe lipid raft resident adaptor molecules LAT1 and Non-T cell activation linker (NTAL), also known as linker for activation of B cells (LAB)/LAT2 are known participants in the regulation of mast cell...
    • SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
      SHC1 events in EGFR signaling, organism-specific biosystemGRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.
    • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
      SOS-mediated signalling, organism-specific biosystemSOS is recruited to the plasma membrane and mediates activation of Ras.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by Leptin, organism-specific biosystem (from REACTOME)
      Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
    • Signaling by MET, organism-specific biosystem (from REACTOME)
      Signaling by MET, organism-specific biosystemMET is a receptor tyrosine kinase (RTK) (Cooper et al. 1984, Park et al. 1984) activated by binding to its ligand, Hepatocyte growth factor/Scatter factor (HGF/SF) (Bottaro et al. 1991, Naldini et al...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
      Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    • Signaling events mediated by TCPTP, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by TCPTP, organism-specific biosystem
      Signaling events mediated by TCPTP
    • Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
      Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
      Signaling of Hepatocyte Growth Factor Receptor
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Signalling to ERKs, organism-specific biosystem (from REACTOME)
      Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
    • Signalling to RAS, organism-specific biosystem (from REACTOME)
      Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
    • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
      Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
    • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
      Stabilization and expansion of the E-cadherin adherens junction
    • Syndecan-1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-1-mediated signaling events, organism-specific biosystem
      Syndecan-1-mediated signaling events
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Ras guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    chemoattractant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    NOT serine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    MAPK cascade TAS
    Traceable Author Statement
    more info
     
    activation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
     
    animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hepatocyte growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelial to mesenchymal transition TAS
    Traceable Author Statement
    more info
    PubMed 
    hepatocyte growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hyaluronan metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-7-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    liver development IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of catabolic autophagy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hydrogen peroxide-mediated programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
     
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron projection regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoblast differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter NAS
    Non-traceable Author Statement
    more info
    PubMed 
    NOT proteolysis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phosphatidylinositol 3-kinase signaling TAS
    Traceable Author Statement
    more info
     
    regulation of tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    hepatocyte growth factor
    Names
    fibroblast-derived tumor cytotoxic factor
    hepatocyte growth factor (hepapoietin A; scatter factor)
    hepatopoietin-A
    lung fibroblast-derived mitogen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016274.2 RefSeqGene

      Range
      4939..76129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000601.5NP_000592.3  hepatocyte growth factor isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_000592.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC004960, AV701693, BU533235, BX495370, M29145, M73240
      Consensus CDS
      CCDS5597.1
      UniProtKB/Swiss-Prot
      P14210
      Related
      ENSP00000222390.5, OTTHUMP00000161349, ENST00000222390.9, OTTHUMT00000253315
      Conserved Domains (5) summary
      smart00020
      Location:494716
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:210290
      KR; Kringle domain
      cd00108
      Location:388470
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      cd00190
      Location:495719
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_001010931.2NP_001010931.1  hepatocyte growth factor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001010931.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons but includes an alternate 3' exon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 2, also named NK2, has been shown to act as a competitive antagonist to active hepatocyte growth factor for the c-Met receptor.
      Source sequence(s)
      BM971901, BU533235, BX495370, L02931
      Consensus CDS
      CCDS47627.1
      UniProtKB/Swiss-Prot
      P14210
      Related
      ENSP00000389854.2, OTTHUMP00000206711, ENST00000444829.6, OTTHUMT00000337134
      Conserved Domains (2) summary
      smart00130
      Location:210289
      KR; Kringle domain
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    3. NM_001010932.2NP_001010932.1  hepatocyte growth factor isoform 3 preproprotein

      See identical proteins and their annotated locations for NP_001010932.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) lacks a portion of the alpha chain and is shorter compared to isoform 1.
      Source sequence(s)
      AC004960, AV701693, BU533235, BX495370, M73240
      Consensus CDS
      CCDS47626.1
      UniProtKB/Swiss-Prot
      P14210
      Related
      ENSP00000391238.2, OTTHUMP00000206713, ENST00000457544.6, OTTHUMT00000337136
      Conserved Domains (5) summary
      smart00020
      Location:489711
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:205285
      KR; Kringle domain
      cd00108
      Location:383465
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      cd00190
      Location:490714
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. NM_001010933.2NP_001010933.1  hepatocyte growth factor isoform 4 precursor

      See identical proteins and their annotated locations for NP_001010933.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal in-frame segment and multiple 3' exons but includes an alternate 3' exon, compared to variant 1. The resulting protein (isoform 4) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC022308, BM971901, BU533235, BX495370, L02931
      Consensus CDS
      CCDS47628.1
      UniProtKB/Swiss-Prot
      P14210
      Related
      ENSP00000408270.1, OTTHUMP00000206710, ENST00000453411.5, OTTHUMT00000337133
      Conserved Domains (2) summary
      smart00130
      Location:205284
      KR; Kringle domain
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    5. NM_001010934.2NP_001010934.1  hepatocyte growth factor isoform 5 precursor

      See identical proteins and their annotated locations for NP_001010934.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks multiple 3' exons but has an alternate 3' segment, compared to variant 1. The resulting protein (isoform 5) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      BC063485, BU533235, BX495370, U46010
      Consensus CDS
      CCDS47629.1
      UniProtKB/Swiss-Prot
      P14210
      Related
      ENSP00000413829.2, OTTHUMP00000206712, ENST00000423064.6, OTTHUMT00000337135
      Conserved Domains (2) summary
      smart00130
      Location:126208
      KR; Kringle domain
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      81699006..81770438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006715956.2XP_006716019.1  hepatocyte growth factor isoform X1

      See identical proteins and their annotated locations for XP_006716019.1

      UniProtKB/Swiss-Prot
      P14210
      Conserved Domains (5) summary
      smart00020
      Location:494716
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:210290
      KR; Kringle domain
      cd00108
      Location:388470
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      cd00190
      Location:495719
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_011516115.2XP_011514417.1  hepatocyte growth factor isoform X2

      See identical proteins and their annotated locations for XP_011514417.1

      UniProtKB/Swiss-Prot
      P14210
      Conserved Domains (5) summary
      smart00020
      Location:489711
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:205285
      KR; Kringle domain
      cd00108
      Location:383465
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      cd00190
      Location:490714
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. XM_017012098.1XP_016867587.1  hepatocyte growth factor isoform X4

      UniProtKB/Swiss-Prot
      P14210
      Conserved Domains (2) summary
      smart00130
      Location:205284
      KR; Kringle domain
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    4. XM_017012097.1XP_016867586.1  hepatocyte growth factor isoform X3

      UniProtKB/Swiss-Prot
      P14210
      Conserved Domains (2) summary
      smart00130
      Location:210289
      KR; Kringle domain
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      81258674..81329573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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