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    TRIM63 tripartite motif containing 63 [ Homo sapiens (human) ]

    Gene ID: 84676, updated on 8-May-2017
    Official Symbol
    TRIM63provided by HGNC
    Official Full Name
    tripartite motif containing 63provided by HGNC
    Primary source
    HGNC:HGNC:16007
    See related
    Ensembl:ENSG00000158022 MIM:606131; Vega:OTTHUMG00000007510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRF; SMRZ; MURF1; MURF2; RNF28
    Summary
    This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]
    Orthologs
    Location:
    1p36.11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (26051304..26067634, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26377792..26394142, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 member 2 Neighboring gene uncharacterized LOC105376910 Neighboring gene uncharacterized LOC105376886 Neighboring gene PDLIM1 interacting kinase 1 like Neighboring gene family with sequence similarity 110 member D

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ32380

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    titin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cardiac muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    response to electrical stimulus involved in regulation of muscle adaptation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    skeletal muscle atrophy IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    M band IEA
    Inferred from Electronic Annotation
    more info
     
    Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    microtubule NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase TRIM63
    Names
    RING-type E3 ubiquitin transferase TRIM63
    iris ring finger protein
    muscle specific ring finger protein 2
    muscle-specific RING finger protein 1
    ring finger protein 28
    striated muscle RING zinc finger protein
    tripartite motif containing 63, E3 ubiquitin protein ligase
    tripartite motif-containing protein 63
    NP_115977.2
    XP_016858048.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033268.1 RefSeqGene

      Range
      5001..21331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_757

    mRNA and Protein(s)

    1. NM_032588.3NP_115977.2  E3 ubiquitin-protein ligase TRIM63

      See identical proteins and their annotated locations for NP_115977.2

      Status: REVIEWED

      Source sequence(s)
      AI351421, BC080529, DA900348
      Consensus CDS
      CCDS273.1
      UniProtKB/Swiss-Prot
      Q969Q1
      Related
      ENSP00000363390.3, OTTHUMP00000008701, ENST00000374272.3, OTTHUMT00000019750
      Conserved Domains (3) summary
      smart00336
      Location:120159
      BBOX; B-Box-type zinc finger
      cd00162
      Location:2382
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl23765
      Location:188283
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      26051304..26067634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002559.1XP_016858048.1  E3 ubiquitin-protein ligase TRIM63 isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      26491024..26507354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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