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    TNFRSF14 TNF receptor superfamily member 14 [ Homo sapiens (human) ]

    Gene ID: 8764, updated on 9-Jul-2017
    Official Symbol
    TNFRSF14provided by HGNC
    Official Full Name
    TNF receptor superfamily member 14provided by HGNC
    Primary source
    HGNC:HGNC:11912
    See related
    Ensembl:ENSG00000157873 MIM:602746; Vega:OTTHUMG00000000792
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TR2; ATAR; HVEA; HVEM; CD270; LIGHTR
    Summary
    This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Orthologs
    Location:
    1p36.32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (2555767..2565622)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (2487291..2495268)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene pantothenate kinase 4 Neighboring gene hes family bHLH transcription factor 5 Neighboring gene TNFRSF14 antisense RNA 1 Neighboring gene uncharacterized LOC100996583 Neighboring gene family with sequence similarity 213 member B Neighboring gene membrane metalloendopeptidase like 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
    NHGRI GWA Catalog
    Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    NHGRI GWA Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    NHGRI GWA Catalog
    Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) in human B cells PubMed
    Vif vif HIV-1 Vif downregulates the expression of tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • TNFR2 non-canonical NF-kB pathway, organism-specific biosystem (from REACTOME)
      TNFR2 non-canonical NF-kB pathway, organism-specific biosystemTumor necrosis factor-alpha (TNFA) exerts a wide range of biological effects through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Under normal physiological conditions TNFR2 exhibits more restr...
    • TNFs bind their physiological receptors, organism-specific biosystem (from REACTOME)
      TNFs bind their physiological receptors, organism-specific biosystemMembers of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity. These members are implicated in various acquir...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ26662

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tumor necrosis factor-activated receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    T cell costimulation TAS
    Traceable Author Statement
    more info
     
    apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine secretion involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    tumor necrosis factor receptor superfamily member 14
    Names
    CD40-like protein
    herpes virus entry mediator A
    tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
    tumor necrosis factor receptor-like gene2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047096.1 RefSeqGene

      Range
      5001..14258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297605.1NP_001284534.1  tumor necrosis factor receptor superfamily member 14 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL139246, BM981793, BX343044, CD366981, DC383433
      Related
      ENSP00000411854.1, OTTHUMP00000204099, ENST00000426449.5, OTTHUMT00000002098
      Conserved Domains (1) summary
      cd10582
      Location:42142
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    2. NM_003820.3NP_003811.2  tumor necrosis factor receptor superfamily member 14 isoform 1 precursor

      See identical proteins and their annotated locations for NP_003811.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL139246, BM981793, CD366981, DC383433, U70321
      Consensus CDS
      CCDS44046.1
      UniProtKB/Swiss-Prot
      Q92956
      UniProtKB/TrEMBL
      A0A024R052
      Related
      ENSP00000347948.4, OTTHUMP00000000866, ENST00000355716.4, OTTHUMT00000002088
      Conserved Domains (3) summary
      cd00185
      Location:138186
      TNFRSF; CRD2 [structural motif]
      cd10582
      Location:42142
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
      cl22855
      Location:98196
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      2555767..2565622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002721.1XP_016858210.1  tumor necrosis factor receptor superfamily member 14 isoform X6

    2. XM_017002720.1XP_016858209.1  tumor necrosis factor receptor superfamily member 14 isoform X4

      UniProtKB/Swiss-Prot
      Q92956
      Conserved Domains (1) summary
      cl22855
      Location:17115
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    3. XM_006711019.2XP_006711082.1  tumor necrosis factor receptor superfamily member 14 isoform X5

      See identical proteins and their annotated locations for XP_006711082.1

      Related
      ENSP00000399533.1, OTTHUMP00000204095, ENST00000451778.5, OTTHUMT00000002093
      Conserved Domains (1) summary
      cd10582
      Location:42142
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    4. XM_017002718.1XP_016858207.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    5. XM_017002719.1XP_016858208.1  tumor necrosis factor receptor superfamily member 14 isoform X2

    6. XM_011542383.2XP_011540685.1  tumor necrosis factor receptor superfamily member 14 isoform X3

      See identical proteins and their annotated locations for XP_011540685.1

    RNA

    1. XR_001737513.1 RNA Sequence

    2. XR_001737512.1 RNA Sequence

    3. XR_426638.2 RNA Sequence

    4. XR_001737511.1 RNA Sequence

      Related
      ENST00000475523.5

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NT_187515.1 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      107555..116812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      2474872..2484129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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