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    CRTC1 CREB regulated transcription coactivator 1 [ Homo sapiens (human) ]

    Gene ID: 23373, updated on 20-Feb-2017
    Official Symbol
    CRTC1provided by HGNC
    Official Full Name
    CREB regulated transcription coactivator 1provided by HGNC
    Primary source
    HGNC:HGNC:16062
    See related
    Ensembl:ENSG00000105662 MIM:607536; Vega:OTTHUMG00000183115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MECT1; TORC1; TORC-1; WAMTP1
    Orthologs
    Location:
    19p13.11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (18683615..18782333)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18794425..18893143)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 59 like Neighboring gene kelch like family member 26 Neighboring gene uncharacterized LOC107985321 Neighboring gene cartilage oligomeric matrix protein

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
    NHGRI GWA Catalog
    Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.
    NHGRI GWA Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog
    • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
      BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
    • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
      Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • Circadian Clock, organism-specific biosystem (from REACTOME)
      Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
    • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
      Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
    • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
      Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
      Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
    • Mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
      Mitochondrial biogenesis, organism-specific biosystemMitochondrial biogenesis and remodeling occur in response to exercise and redox state (reviewed in Scarpulla et al. 2012, Handy and Loscalzo 2012, Piantadosi and Suliman 2012, Scarpulla 2011, Wenz et...
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • Transcriptional activation of mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
      Transcriptional activation of mitochondrial biogenesis, organism-specific biosystemPhosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ14027, KIAA0616

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cAMP response element binding protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    energy homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    entrainment of circadian clock by photoperiod ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane hyperpolarization IEA
    Inferred from Electronic Annotation
    more info
     
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of CREB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of CREB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    CREB-regulated transcription coactivator 1
    Names
    CRTC1
    mucoepidermoid carcinoma translocated protein 1
    transducer of regulated cAMP response element-binding protein (CREB) 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098482.1NP_001091952.1  CREB-regulated transcription coactivator 1 isoform 3

      See identical proteins and their annotated locations for NP_001091952.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
      Source sequence(s)
      AB014516, AU118537, BC023614, BM680095, DB355148
      Consensus CDS
      CCDS42525.1
      UniProtKB/Swiss-Prot
      Q6UUV9
      Related
      ENSP00000345001, OTTHUMP00000270905, ENST00000338797, OTTHUMT00000465152
      Conserved Domains (3) summary
      pfam12884
      Location:666
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:164309
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:575650
      TORC_C; Transducer of regulated CREB activity, C terminus
    2. NM_015321.2NP_056136.2  CREB-regulated transcription coactivator 1 isoform 1

      See identical proteins and their annotated locations for NP_056136.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AB014516, AU118537, BC023614, BC028050, BM680095, DB355148
      Consensus CDS
      CCDS32963.1
      UniProtKB/Swiss-Prot
      Q6UUV9
      Related
      ENSP00000323332, OTTHUMP00000270904, ENST00000321949, OTTHUMT00000465151
      Conserved Domains (3) summary
      pfam12884
      Location:666
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:148293
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:559634
      TORC_C; Transducer of regulated CREB activity, C terminus

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      18683615..18782333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259834.1XP_005259891.1  CREB-regulated transcription coactivator 1 isoform X3

      Conserved Domains (3) summary
      pfam12884
      Location:666
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:148293
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:530605
      TORC_C; Transducer of regulated CREB activity, C terminus
    2. XM_005259833.3XP_005259890.1  CREB-regulated transcription coactivator 1 isoform X1

      See identical proteins and their annotated locations for XP_005259890.1

      Conserved Domains (3) summary
      pfam12884
      Location:666
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:164309
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:546621
      TORC_C; Transducer of regulated CREB activity, C terminus
    3. XM_011527842.2XP_011526144.1  CREB-regulated transcription coactivator 1 isoform X2

      Conserved Domains (3) summary
      pfam12884
      Location:666
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:164309
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:540615
      TORC_C; Transducer of regulated CREB activity, C terminus
    4. XM_017026536.1XP_016882025.1  CREB-regulated transcription coactivator 1 isoform X4

    5. XM_017026537.1XP_016882026.1  CREB-regulated transcription coactivator 1 isoform X8

    6. XM_017026538.1XP_016882027.1  CREB-regulated transcription coactivator 1 isoform X9

    7. XM_005259835.3XP_005259892.1  CREB-regulated transcription coactivator 1 isoform X5

      Conserved Domains (3) summary
      pfam12884
      Location:666
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:164309
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:489564
      TORC_C; Transducer of regulated CREB activity, C terminus
    8. XM_005259836.3XP_005259893.1  CREB-regulated transcription coactivator 1 isoform X6

      Conserved Domains (3) summary
      pfam12884
      Location:666
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:164309
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:454529
      TORC_C; Transducer of regulated CREB activity, C terminus
    9. XM_006722710.3XP_006722773.1  CREB-regulated transcription coactivator 1 isoform X7

      Conserved Domains (3) summary
      pfam12884
      Location:666
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:164309
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:437512
      TORC_C; Transducer of regulated CREB activity, C terminus

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      18853765..18893147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025021.1: Suppressed sequence

      Description
      NM_025021.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center