Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    SIGLEC1 sialic acid binding Ig like lectin 1 [ Homo sapiens (human) ]

    Gene ID: 6614, updated on 23-Jul-2017
    Official Symbol
    SIGLEC1provided by HGNC
    Official Full Name
    sialic acid binding Ig like lectin 1provided by HGNC
    Primary source
    HGNC:HGNC:11127
    See related
    Ensembl:ENSG00000088827 MIM:600751; Vega:OTTHUMG00000031757
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SN; CD169; SIGLEC-1; dJ1009E24.1
    Summary
    This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    20p13
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (3686970..3712558, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3667617..3693213, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene GDNF family receptor alpha 4 Neighboring gene ADAM metallopeptidase domain 33 Neighboring gene heat shock protein family A (Hsp70) member 12B Neighboring gene chromosome 20 open reading frame 27

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Interferon-alpha- and interferon-gamma-induced sialoadhesin-expressing monocytes adsorb HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120 PubMed
    Pr55(Gag) gag Co-localization of HIV-1 Gag virus-like particles in THP-1/CD169YF cells is reduced within CD81+ compartments, but enhanced within CD63+ or LAMP1+ compartments PubMed
    gag HIV-1 Gag co-localizes with Siglec-1 in the sac-like compartment PubMed
    capsid gag IFN-gamma-activated dendritic cells, monocytes, and macrophages have an enhanced ability to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides in terms of detected levels of p24 PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ00051, FLJ00055, FLJ00073, FLJ00411, FLJ32150, DKFZp667F058

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-matrix adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    single organismal cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    sialoadhesin
    Names
    sialic acid binding Ig-like lectin 1, sialoadhesin
    sialic acid-binding immunoglobulin-like lectin 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023068.3NP_075556.1  sialoadhesin precursor

      See identical proteins and their annotated locations for NP_075556.1

      Status: REVIEWED

      Source sequence(s)
      AF230073, AK024462, AY927519, CD365566
      Consensus CDS
      CCDS13060.1
      UniProtKB/Swiss-Prot
      Q9BZZ2
      Related
      ENSP00000341141.4, OTTHUMP00000030124, ENST00000344754.5, OTTHUMT00000077761
      Conserved Domains (8) summary
      cd00096
      Location:430503
      Ig; Immunoglobulin domain
      smart00409
      Location:516594
      IG; Immunoglobulin
      smart00410
      Location:247323
      IG_like; Immunoglobulin like
      pfam07679
      Location:898980
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:715788
      ig; Immunoglobulin domain
      pfam08205
      Location:142228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:245323
      Ig_2; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      3686970..3712558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529325.2XP_011527627.1  sialoadhesin isoform X1

      See identical proteins and their annotated locations for XP_011527627.1

      UniProtKB/Swiss-Prot
      Q9BZZ2
      Conserved Domains (8) summary
      cd00096
      Location:430503
      Ig; Immunoglobulin domain
      smart00409
      Location:516594
      IG; Immunoglobulin
      smart00410
      Location:247323
      IG_like; Immunoglobulin like
      pfam07679
      Location:898980
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:715788
      ig; Immunoglobulin domain
      pfam08205
      Location:142228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:245323
      Ig_2; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain
    2. XM_011529326.2XP_011527628.1  sialoadhesin isoform X1

      See identical proteins and their annotated locations for XP_011527628.1

      UniProtKB/Swiss-Prot
      Q9BZZ2
      Conserved Domains (8) summary
      cd00096
      Location:430503
      Ig; Immunoglobulin domain
      smart00409
      Location:516594
      IG; Immunoglobulin
      smart00410
      Location:247323
      IG_like; Immunoglobulin like
      pfam07679
      Location:898980
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:715788
      ig; Immunoglobulin domain
      pfam08205
      Location:142228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:245323
      Ig_2; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain
    3. XM_011529324.2XP_011527626.1  sialoadhesin isoform X1

      See identical proteins and their annotated locations for XP_011527626.1

      UniProtKB/Swiss-Prot
      Q9BZZ2
      Conserved Domains (8) summary
      cd00096
      Location:430503
      Ig; Immunoglobulin domain
      smart00409
      Location:516594
      IG; Immunoglobulin
      smart00410
      Location:247323
      IG_like; Immunoglobulin like
      pfam07679
      Location:898980
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:715788
      ig; Immunoglobulin domain
      pfam08205
      Location:142228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:245323
      Ig_2; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain
    4. XM_006723610.3XP_006723673.1  sialoadhesin isoform X1

      See identical proteins and their annotated locations for XP_006723673.1

      UniProtKB/Swiss-Prot
      Q9BZZ2
      Conserved Domains (8) summary
      cd00096
      Location:430503
      Ig; Immunoglobulin domain
      smart00409
      Location:516594
      IG; Immunoglobulin
      smart00410
      Location:247323
      IG_like; Immunoglobulin like
      pfam07679
      Location:898980
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:715788
      ig; Immunoglobulin domain
      pfam08205
      Location:142228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:245323
      Ig_2; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain
    5. XM_011529328.2XP_011527630.1  sialoadhesin isoform X1

      See identical proteins and their annotated locations for XP_011527630.1

      UniProtKB/Swiss-Prot
      Q9BZZ2
      Conserved Domains (8) summary
      cd00096
      Location:430503
      Ig; Immunoglobulin domain
      smart00409
      Location:516594
      IG; Immunoglobulin
      smart00410
      Location:247323
      IG_like; Immunoglobulin like
      pfam07679
      Location:898980
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:715788
      ig; Immunoglobulin domain
      pfam08205
      Location:142228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:245323
      Ig_2; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain
    6. XM_011529327.2XP_011527629.1  sialoadhesin isoform X1

      See identical proteins and their annotated locations for XP_011527629.1

      UniProtKB/Swiss-Prot
      Q9BZZ2
      Conserved Domains (8) summary
      cd00096
      Location:430503
      Ig; Immunoglobulin domain
      smart00409
      Location:516594
      IG; Immunoglobulin
      smart00410
      Location:247323
      IG_like; Immunoglobulin like
      pfam07679
      Location:898980
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:715788
      ig; Immunoglobulin domain
      pfam08205
      Location:142228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:245323
      Ig_2; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain
    7. XM_011529331.1XP_011527633.1  sialoadhesin isoform X4

      Conserved Domains (7) summary
      cd00096
      Location:341414
      Ig; Immunoglobulin domain
      smart00409
      Location:427505
      IG; Immunoglobulin
      smart00410
      Location:158234
      IG_like; Immunoglobulin like
      pfam07679
      Location:809891
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:53139
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:156234
      Ig_2; Immunoglobulin domain
      cl11960
      Location:147
      Ig; Immunoglobulin domain
    8. XM_011529330.1XP_011527632.1  sialoadhesin isoform X3

      Conserved Domains (8) summary
      cd00096
      Location:430503
      Ig; Immunoglobulin domain
      smart00409
      Location:338408
      IG; Immunoglobulin
      smart00410
      Location:247323
      IG_like; Immunoglobulin like
      pfam07679
      Location:812894
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:629702
      ig; Immunoglobulin domain
      pfam08205
      Location:142228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:245323
      Ig_2; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain
    9. XM_011529329.1XP_011527631.1  sialoadhesin isoform X2

      UniProtKB/Swiss-Prot
      Q9BZZ2
      Conserved Domains (8) summary
      cd00096
      Location:430503
      Ig; Immunoglobulin domain
      smart00409
      Location:516594
      IG; Immunoglobulin
      smart00410
      Location:247323
      IG_like; Immunoglobulin like
      pfam07679
      Location:898980
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:715788
      ig; Immunoglobulin domain
      pfam08205
      Location:142228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:245323
      Ig_2; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain
    10. XM_011529332.1XP_011527634.1  sialoadhesin isoform X5

      Conserved Domains (7) summary
      cd00096
      Location:227300
      Ig; Immunoglobulin domain
      smart00409
      Location:313391
      IG; Immunoglobulin
      smart00410
      Location:44120
      IG_like; Immunoglobulin like
      pfam07679
      Location:695777
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:512585
      ig; Immunoglobulin domain
      pfam13895
      Location:42120
      Ig_2; Immunoglobulin domain
      cl11960
      Location:133205
      Ig; Immunoglobulin domain
    11. XM_011529333.2XP_011527635.1  sialoadhesin isoform X6

      Conserved Domains (7) summary
      cd00096
      Location:430503
      Ig; Immunoglobulin domain
      smart00409
      Location:431503
      IG; Immunoglobulin
      smart00410
      Location:247317
      IG_like; Immunoglobulin like
      pfam07679
      Location:898980
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:142228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:245323
      Ig_2; Immunoglobulin domain
      cl11960
      Location:21136
      Ig; Immunoglobulin domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      3667931..3688082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center