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    DHX9 DExH-box helicase 9 [ Homo sapiens (human) ]

    Gene ID: 1660, updated on 8-Oct-2017
    Official Symbol
    DHX9provided by HGNC
    Official Full Name
    DExH-box helicase 9provided by HGNC
    Primary source
    HGNC:HGNC:2750
    See related
    Ensembl:ENSG00000135829 MIM:603115; Vega:OTTHUMG00000035337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LKP; RHA; DDX9; NDH2; NDHII
    Summary
    This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]
    Orthologs
    Location:
    1q25.3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (182839304..182887982)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182808439..182857117)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene regulator of G protein signaling 8 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component pseudogene Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene uncharacterized LOC647070 Neighboring gene SHC binding and spindle associated 1 like Neighboring gene RNA, 5S ribosomal pseudogene 71 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 4

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    HIV-1 infectivity is enhanced by DHX9 (RHA) binding to the primer binding site (PBS)-segment of dimeric HIV-1 5'-UTR PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ATP-dependent RNA helicase A (RHA, DHX9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol HIV-1 Gag-Pol polyprotein is reduced by siRNA-mediated RHA (DHX9) downregulation, suggesting that RHA regulates Gag-Pol expression PubMed
    gag-pol Tandem affinity purification and mass spectrometry analysis identify ATP-dependent RNA helicase A (RHA, DHX9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef HIV-1 Nef is reduced by siRNA-mediated RHA (DHX9) downregulation, suggesting that RHA regulates Nef expression PubMed
    nef Tandem affinity purification and mass spectrometry analysis identify ATP-dependent RNA helicase A (RHA, DHX9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ATP-dependent RNA helicase A (RHA, DHX9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag HIV-1 RU5 is necessary for post-transcriptional control element (PCE) activity and interaction with Dhx9/RNA helicase A (RHA). RHA is necessary for efficient production of HIV-1 Gag PubMed
    gag HIV-1 Gag interacts with RNA helicase A (RHA) in an RNA-dependent manner, and RHA binds HIV-1 RNA PubMed
    Rev rev HIV-1 Rev is reduced by siRNA-mediated RHA (DHX9) downregulation, suggesting that RHA regulates Rev expression PubMed
    rev RNA helicase A is a cofactor that binds to the Rev responsive element (RRE) of HIV-1 mRNA during Rev-mediated nuclear export of mRNA PubMed
    rev HIV-1 Rev interacting protein, DEAH (Asp-Glu-Ala-His) box polypeptide 9 (DHX9), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with DHX9 is increased by RRE PubMed
    Tat tat Interaction of HIV-1 Tat with RHA in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed
    Vif vif HIV-1 Vif is reduced by siRNA-mediated RHA downregulation, suggesting that RHA regulates Vif expression PubMed
    reverse transcriptase gag-pol HIV-1 RT p66 is reduced by siRNA-mediated RHA downregulation, suggesting that RHA regulates RT p66 expression PubMed

    Go to the HIV-1, Human Interaction Database

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
      Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
    • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
      Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
    • Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem (from REACTOME)
      Cytosolic sensors of pathogen-associated DNA, organism-specific biosystemPresence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon ...
    • DEx/H-box helicases activate type I IFN and inflammatory cytokines production, organism-specific biosystem (from REACTOME)
      DEx/H-box helicases activate type I IFN and inflammatory cytokines production, organism-specific biosystemDHX36 and DHX9 are aspartate-glutamate-any amino acid aspartate/histidine (DExD/H) box helicase (DHX) proteins that localize in the cytosol. The DHX RNA helicases family includes a large number of pr...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
    • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
      MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
    • MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
      MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemMyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from ...
    • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • RIP-mediated NFkB activation via ZBP1, organism-specific biosystem (from REACTOME)
      RIP-mediated NFkB activation via ZBP1, organism-specific biosystemOverexpression of human or murine ZBP1 (DAI) in human embryonic kidney 293T cells (HEK293T) activated NF-kB-dependent promoter in a dose-dependent manner. Two RHIM-contaning kinases RIP1 and RIP3 are...
    • TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
      TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemNF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting...
    • TRAF6 mediated NF-kB activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated NF-kB activation, organism-specific biosystemThe TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in To...
    • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
    • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
      TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
    • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
    • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
    • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
    • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
    • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
    • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
    • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • ZBP1(DAI) mediated induction of type I IFNs, organism-specific biosystem (from REACTOME)
      ZBP1(DAI) mediated induction of type I IFNs, organism-specific biosystemZ-DNA-binding protein-1 (ZBP1), also known as, DNA-dependent activator of IFN-regulatory factors (DAI) was reported to initiate innate immune responses in murine L929 cells upon stimulation by multip...
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ17406

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP-dependent 3'-5' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP-dependent 3'-5' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ATP-dependent 3'-5' DNA/RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP-dependent 3'-5' RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP-dependent DNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ATP-dependent RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP-dependent RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ATPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ATPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RISC complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA helicase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA polymerase II core binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA polymerase II transcription cofactor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA polymerase II transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA stem-loop binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    importin-alpha family protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside-triphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoside-triphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polysome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    promoter-specific chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulatory region RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    siRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    triplex DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    CRD-mediated mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA duplex unwinding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA duplex unwinding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA duplex unwinding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-templated transcription, termination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-templated viral transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-quadruplex DNA unwinding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA secondary structure unwinding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to tumor necrosis factor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of RNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interferon-alpha secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-beta secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-18 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-6 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of polysome binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of response to cytokine stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of tumor necrosis factor secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of type I interferon production TAS
    Traceable Author Statement
    more info
     
    positive regulation of viral transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of viral translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to cytoplasmic stress granule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pyroptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of defense response to virus by host ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of mRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    small RNA loading onto RISC IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    targeting of mRNA for destruction involved in RNA interference IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    CRD-mediated mRNA stability complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RISC-loading complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    intracellular ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ribonucleoprotein complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    micro-ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear stress granule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perichromatin fibrils IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polysomal ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polysome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ATP-dependent RNA helicase A
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9
    DEAH (Asp-Glu-Ala-His) box helicase 9
    DEAH (Asp-Glu-Ala-His) box polypeptide 9
    DEAH box protein 9
    DEAH-box helicase 9
    RNA helicase A
    leukophysin
    nuclear DNA helicase II
    NP_001348.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029930.1 RefSeqGene

      Range
      5001..53679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001357.4NP_001348.2  ATP-dependent RNA helicase A

      See identical proteins and their annotated locations for NP_001348.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AA836637, AK096582, BC137136, DB223823
      Consensus CDS
      CCDS41444.1
      UniProtKB/Swiss-Prot
      Q08211
      UniProtKB/TrEMBL
      B3KU66
      Related
      ENSP00000356520.3, OTTHUMP00000033287, ENST00000367549.3, OTTHUMT00000085522
      Conserved Domains (6) summary
      smart00358
      Location:569
      DSRM; Double-stranded RNA binding motif
      smart00847
      Location:838919
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:3811095
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:405546
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:635768
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:9591073
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RNA

    1. NR_033302.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported/expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA836637, AK226102, AL355999, DB223823

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      182839304..182887982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      184231696..184280375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030588.1: Suppressed sequence

      Description
      NM_030588.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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