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    DIDO1 death inducer-obliterator 1 [ Homo sapiens (human) ]

    Gene ID: 11083, updated on 5-Nov-2017
    Official Symbol
    DIDO1provided by HGNC
    Official Full Name
    death inducer-obliterator 1provided by HGNC
    Primary source
    HGNC:HGNC:2680
    See related
    Ensembl:ENSG00000101191 MIM:604140; Vega:OTTHUMG00000032945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BYE1; DIO1; DATF1; DIDO2; DIDO3; DIO-1; DATF-1; C20orf158; dJ885L7.8
    Summary
    Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    20q13.33
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (62877738..62937952, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61509090..61569304, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene transcription factor like 5 Neighboring gene diphthamide biosynthesis 3 pseudogene 1 Neighboring gene uncharacterized LOC105372717 Neighboring gene ADP ribosylation factor 4 pseudogene 2 Neighboring gene GID complex subunit 8 homolog Neighboring gene solute carrier family 17 member 9

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Meiosis, organism-specific biosystem (from REACTOME)
      Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
    • Meiotic synapsis, organism-specific biosystem (from REACTOME)
      Meiotic synapsis, organism-specific biosystemMeiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form a...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ11265, KIAA0333, MGC16140, DKFZp434P1115

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    spindle IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    death-inducer obliterator 1
    Names
    death-associated transcription factor 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029496.1 RefSeqGene

      Range
      5001..65215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001193369.1NP_001180298.1  death-inducer obliterator 1 isoform c

      See identical proteins and their annotated locations for NP_001180298.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains a different segment for its 5' UTR, compared to variant 4. Variants 4 and 5 encode the same protein (isoform c).
      Source sequence(s)
      AB002331, AY481572, CK300739, DA506324
      Consensus CDS
      CCDS33506.1
      UniProtKB/Swiss-Prot
      Q9BTC0
      Related
      ENSP00000378752.1, OTTHUMP00000031522, ENST00000395343.5, OTTHUMT00000080091
      Conserved Domains (4) summary
      smart00510
      Location:672773
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:160302
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:266319
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10571163
      SPOC; SPOC domain
    2. NM_001193370.1NP_001180299.1  death-inducer obliterator 1 isoform b

      See identical proteins and their annotated locations for NP_001180299.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains a different 5' UTR segment and a different terminal exon, compared to variant 4. It encodes a protein (isoform b) that has a distinct and shorter C-terminus when it is compared to isoform c. Variants 3 and 6 encode the same protein (isoform c).
      Source sequence(s)
      AB002331, AL035669, AW206895, AY481571, DA506324
      Consensus CDS
      CCDS13508.2
      UniProtKB/Swiss-Prot
      Q9BTC0
      Related
      ENSP00000378749.1, OTTHUMP00000031521, ENST00000395340.5, OTTHUMT00000080090
      Conserved Domains (4) summary
      smart00510
      Location:672773
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:160302
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:266319
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10571163
      SPOC; SPOC domain
    3. NM_022105.4NP_071388.2  death-inducer obliterator 1 isoform a

      See identical proteins and their annotated locations for NP_071388.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has a different segment and lacks most of the 3' coding region, compared to variant 4. The resulting protein (isoform a) has a shorter and distinct C-terminus when it is compared to isoform c. Variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AI291497, BC004237, DA294135, DB460917
      Consensus CDS
      CCDS13509.1
      UniProtKB/Swiss-Prot
      Q9BTC0
      Related
      ENSP00000359397.4, OTTHUMP00000031518, ENST00000370371.8, OTTHUMT00000080087
      Conserved Domains (2) summary
      cd15639
      Location:266319
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      cl26267
      Location:160302
      ING; Inhibitor of growth proteins N-terminal histone-binding
    4. NM_033081.2NP_149072.2  death-inducer obliterator 1 isoform c

      See identical proteins and their annotated locations for NP_149072.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest protein (isoform c). Variants 4 and 5 encode the same protein.
      Source sequence(s)
      AB002331, AY481572, CK300739, CN348578, CN370112, DA294135
      Consensus CDS
      CCDS33506.1
      UniProtKB/Swiss-Prot
      Q9BTC0
      Related
      ENSP00000266070.4, ENST00000266070.8
      Conserved Domains (4) summary
      smart00510
      Location:672773
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:160302
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:266319
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10571163
      SPOC; SPOC domain
    5. NM_080796.3NP_542986.1  death-inducer obliterator 1 isoform a

      See identical proteins and their annotated locations for NP_542986.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a different 5' UTR segment and lacks most of the 3' coding region, compared to variant 4. The resulting protein (isoform a) has a shorter and distinct C-terminus when it is compared to isoform c. Variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AI291497, BC014489, DA506324
      Consensus CDS
      CCDS13509.1
      UniProtKB/Swiss-Prot
      Q9BTC0
      Related
      ENSP00000346692.4, OTTHUMP00000031520, ENST00000354665.8, OTTHUMT00000080089
      Conserved Domains (2) summary
      cd15639
      Location:266319
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      cl26267
      Location:160302
      ING; Inhibitor of growth proteins N-terminal histone-binding
    6. NM_080797.3NP_542987.2  death-inducer obliterator 1 isoform b

      See identical proteins and their annotated locations for NP_542987.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a different terminal exon, compared to variant 4. It encodes a protein (isoform b) that has a distinct and shorter C-terminus when it is compared to isoform c. Variants 3 and 6 encode the same protein (isoform c).
      Source sequence(s)
      AB002331, AL035669, AW206895, DA294135
      Consensus CDS
      CCDS13508.2
      UniProtKB/Swiss-Prot
      Q9BTC0
      Conserved Domains (4) summary
      smart00510
      Location:672773
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:160302
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:266319
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10571163
      SPOC; SPOC domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      62877738..62937952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528505.1XP_011526807.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_011526807.1

      Conserved Domains (4) summary
      smart00510
      Location:708809
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:160302
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:266319
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10931199
      SPOC; SPOC domain
    2. XM_011528506.1XP_011526808.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_011526808.1

      Conserved Domains (4) summary
      smart00510
      Location:708809
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:160302
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:266319
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10931199
      SPOC; SPOC domain
    3. XM_011528504.1XP_011526806.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_011526806.1

      Conserved Domains (4) summary
      smart00510
      Location:708809
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:160302
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:266319
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10931199
      SPOC; SPOC domain
    4. XM_011528507.1XP_011526809.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_011526809.1

      Conserved Domains (4) summary
      smart00510
      Location:708809
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:160302
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:266319
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10931199
      SPOC; SPOC domain
    5. XM_011528508.1XP_011526810.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_011526810.1

      Conserved Domains (4) summary
      smart00510
      Location:708809
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:160302
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:266319
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10931199
      SPOC; SPOC domain
    6. XM_011528509.2XP_011526811.1  death-inducer obliterator 1 isoform X2

      See identical proteins and their annotated locations for XP_011526811.1

      UniProtKB/Swiss-Prot
      Q9BTC0
      Conserved Domains (4) summary
      smart00510
      Location:672773
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:160302
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:266319
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10571163
      SPOC; SPOC domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      61410099..61470313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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