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    MPLKIP M-phase specific PLK1 interacting protein [ Homo sapiens (human) ]

    Gene ID: 136647, updated on 9-Apr-2018
    Official Symbol
    MPLKIPprovided by HGNC
    Official Full Name
    M-phase specific PLK1 interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16002
    See related
    Ensembl:ENSG00000168303 MIM:609188; Vega:OTTHUMG00000128797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ABHS; TTD4; ORF20; C7orf11
    Summary
    The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]
    Expression
    Ubiquitous expression in liver (RPKM 18.5), kidney (RPKM 17.4) and 25 other tissues See more
    Orthologs
    Location:
    7p14.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (40132743..40134652, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (40172342..40174251, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene protein enabled homolog Neighboring gene cyclin dependent kinase 13 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 7 Neighboring gene THUMP domain containing 3 pseudogene 1 Neighboring gene succinyl-CoA:glutarate-CoA transferase Neighboring gene uncharacterized LOC105375245

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    M-phase-specific PLK1-interacting protein
    Names
    Russell-Silver syndrome region
    TTD non-photosensitive 1 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016989.2 RefSeqGene

      Range
      5001..6910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138701.3NP_619646.1  M-phase-specific PLK1-interacting protein

      See identical proteins and their annotated locations for NP_619646.1

      Status: REVIEWED

      Source sequence(s)
      BC026265, BG501110
      Consensus CDS
      CCDS5463.1
      UniProtKB/Swiss-Prot
      Q8TAP9
      UniProtKB/TrEMBL
      A4D1W6
      Related
      ENSP00000495808.1, OTTHUMP00000159010, ENST00000645701.1, OTTHUMT00000250729
      Conserved Domains (1) summary
      pfam15502
      Location:125179
      MPLKIP; M-phase-specific PLK1-interacting protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      40132743..40134652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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