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    USP28 ubiquitin specific peptidase 28 [ Homo sapiens (human) ]

    Gene ID: 57646, updated on 8-Jun-2017
    Official Symbol
    USP28provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 28provided by HGNC
    Primary source
    HGNC:HGNC:12625
    See related
    Ensembl:ENSG00000048028 MIM:610748; Vega:OTTHUMG00000168205
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]
    Orthologs
    Location:
    11q23.2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (113797875..113875580, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113668597..113746292, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37 member A13, pseudogene Neighboring gene activating transcription factor 4 pseudogene 4 Neighboring gene interferon stimulated exonuclease gene 20kDa like 2 pseudogene Neighboring gene RNA, U6 small nuclear 1107, pseudogene Neighboring gene 5-hydroxytryptamine receptor 3B Neighboring gene 5-hydroxytryptamine receptor 3A

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
      Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Clone Names

    • KIAA1515

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thiol-dependent ubiquitinyl hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thiol-dependent ubiquitinyl hydrolase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 28
    Names
    deubiquitinating enzyme 28
    ubiquitin carboxyl-terminal hydrolase 28 variant 1
    ubiquitin thioesterase 28
    ubiquitin thiolesterase 28
    ubiquitin-specific-processing protease 28
    NP_001287958.1
    NP_065937.1
    XP_005271687.1
    XP_005271688.1
    XP_005271689.1
    XP_005271690.1
    XP_005271693.1
    XP_005271694.1
    XP_005271695.1
    XP_005271696.1
    XP_011541238.1
    XP_011541240.1
    XP_011541243.1
    XP_011541244.1
    XP_016873545.1
    XP_016873546.1
    XP_016873547.1
    XP_016873548.1
    XP_016873549.1
    XP_016873550.1
    XP_016873551.1
    XP_016873552.1
    XP_016873553.1
    XP_016873554.1
    XP_016873555.1
    XP_016873556.1
    XP_016873557.1
    XP_016873558.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051668.1 RefSeqGene

      Range
      5001..82696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001301029.1NP_001287958.1  ubiquitin carboxyl-terminal hydrolase 28 isoform b

      See identical proteins and their annotated locations for NP_001287958.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variant 12, encodes isoform b (also known as isoform 2).
      Source sequence(s)
      AK304770, AP003170, BC035986, BF434481, DB061316
      Consensus CDS
      CCDS73394.1
      UniProtKB/TrEMBL
      B4E3L3
      Related
      ENSP00000444991.1, OTTHUMP00000238297, ENST00000545540.5, OTTHUMT00000398791
      Conserved Domains (3) summary
      cd02665
      Location:38523
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:38142
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:36273
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. NM_001346252.1NP_001333181.1  ubiquitin carboxyl-terminal hydrolase 28 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (c).
      Source sequence(s)
      AP001874, AP003170, KF459544
    3. NM_001346253.1NP_001333182.1  ubiquitin carboxyl-terminal hydrolase 28 isoform d

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    4. NM_001346254.1NP_001333183.1  ubiquitin carboxyl-terminal hydrolase 28 isoform e

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    5. NM_001346255.1NP_001333184.1  ubiquitin carboxyl-terminal hydrolase 28 isoform f

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    6. NM_001346257.1NP_001333186.1  ubiquitin carboxyl-terminal hydrolase 28 isoform g

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    7. NM_001346258.1NP_001333187.1  ubiquitin carboxyl-terminal hydrolase 28 isoform h

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/Swiss-Prot
      Q96RU2
    8. NM_001346259.1NP_001333188.1  ubiquitin carboxyl-terminal hydrolase 28 isoform i

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    9. NM_001346260.1NP_001333189.1  ubiquitin carboxyl-terminal hydrolase 28 isoform j

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    10. NM_001346261.1NP_001333190.1  ubiquitin carboxyl-terminal hydrolase 28 isoform k

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    11. NM_001346262.1NP_001333191.1  ubiquitin carboxyl-terminal hydrolase 28 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variant 2, encodes isoform b.
      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/TrEMBL
      B4E3L3
    12. NM_001346263.1NP_001333192.1  ubiquitin carboxyl-terminal hydrolase 28 isoform l

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    13. NM_001346264.1NP_001333193.1  ubiquitin carboxyl-terminal hydrolase 28 isoform m

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    14. NM_001346265.1NP_001333194.1  ubiquitin carboxyl-terminal hydrolase 28 isoform n

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    15. NM_001346267.1NP_001333196.1  ubiquitin carboxyl-terminal hydrolase 28 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 17, encodes isoform o.
      Source sequence(s)
      AP001874, AP003170, KF459544
    16. NM_001346268.1NP_001333197.1  ubiquitin carboxyl-terminal hydrolase 28 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 16, encodes isoform o.
      Source sequence(s)
      AP001874, AP003170, KF459544
    17. NM_001346269.1NP_001333198.1  ubiquitin carboxyl-terminal hydrolase 28 isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 19 and 20, encodes isoform p.
      Source sequence(s)
      AP001874, AP003170, KF459544
    18. NM_001346270.1NP_001333199.1  ubiquitin carboxyl-terminal hydrolase 28 isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 18 and 20, encodes isoform p.
      Source sequence(s)
      AP001874, AP003170, KF459544
    19. NM_001346271.1NP_001333200.1  ubiquitin carboxyl-terminal hydrolase 28 isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 18 and 19, encodes isoform p.
      Source sequence(s)
      AP001874, AP003170, KF459544
    20. NM_001346272.1NP_001333201.1  ubiquitin carboxyl-terminal hydrolase 28 isoform q

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    21. NM_001346273.1NP_001333202.1  ubiquitin carboxyl-terminal hydrolase 28 isoform r

      Status: REVIEWED

      Source sequence(s)
      BC065928, DB061316
      UniProtKB/Swiss-Prot
      Q96RU2
    22. NM_020886.3NP_065937.1  ubiquitin carboxyl-terminal hydrolase 28 isoform a

      See identical proteins and their annotated locations for NP_065937.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a (also known as isoform 1).
      Source sequence(s)
      AF266283, AP003170, BC035986, BF434481, DB061316
      Consensus CDS
      CCDS31680.1
      UniProtKB/Swiss-Prot
      Q96RU2
      Related
      ENSP00000003302.4, OTTHUMP00000238295, ENST00000003302.8, OTTHUMT00000398789
      Conserved Domains (4) summary
      cd02665
      Location:163648
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:2364
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      cl02553
      Location:163267
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:161398
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      113797875..113875580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018058.1XP_016873547.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X10

    2. XM_017018062.1XP_016873551.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X17

    3. XM_017018060.1XP_016873549.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X15

    4. XM_017018061.1XP_016873550.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X16

    5. XM_011542938.1XP_011541240.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X14

      Conserved Domains (3) summary
      cd02665
      Location:38524
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:38142
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:36274
      UCH; Ubiquitin carboxyl-terminal hydrolase
    6. XM_005271639.2XP_005271696.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X12

      Conserved Domains (4) summary
      cd02665
      Location:163648
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:2364
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      cl02553
      Location:163267
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:161398
      UCH; Ubiquitin carboxyl-terminal hydrolase
    7. XM_005271631.2XP_005271688.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X2

      Conserved Domains (4) summary
      cd02665
      Location:163648
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:2364
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      cl02553
      Location:163267
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:161398
      UCH; Ubiquitin carboxyl-terminal hydrolase
    8. XM_005271636.2XP_005271693.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X7

      Conserved Domains (3) summary
      cd02665
      Location:163589
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:2364
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      pfam00443
      Location:161588
      UCH; Ubiquitin carboxyl-terminal hydrolase
    9. XM_005271638.2XP_005271695.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X11

      Conserved Domains (4) summary
      cd02665
      Location:163649
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:2364
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      cl02553
      Location:163267
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:161399
      UCH; Ubiquitin carboxyl-terminal hydrolase
    10. XM_005271637.2XP_005271694.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X8

      Conserved Domains (4) summary
      cd02665
      Location:163649
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:2364
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      cl02553
      Location:163267
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:161399
      UCH; Ubiquitin carboxyl-terminal hydrolase
    11. XM_005271630.2XP_005271687.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X1

      Conserved Domains (4) summary
      cd02665
      Location:163649
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:2364
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      cl02553
      Location:163267
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:161399
      UCH; Ubiquitin carboxyl-terminal hydrolase
    12. XM_017018059.1XP_016873548.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X13

    13. XM_017018056.1XP_016873545.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X6

    14. XM_011542936.2XP_011541238.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X5

      Conserved Domains (3) summary
      cd02665
      Location:137623
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:137241
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:135373
      UCH; Ubiquitin carboxyl-terminal hydrolase
    15. XM_017018065.1XP_016873554.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X21

    16. XM_017018057.1XP_016873546.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X9

    17. XM_017018066.1XP_016873555.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X21

    18. XM_005271632.2XP_005271689.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X3

      Conserved Domains (4) summary
      cd02665
      Location:160646
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:2061
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      cl02553
      Location:160264
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:158396
      UCH; Ubiquitin carboxyl-terminal hydrolase
    19. XM_017018063.1XP_016873552.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X18

      Conserved Domains (1) summary
      cd02665
      Location:1361
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    20. XM_017018067.1XP_016873556.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X21

    21. XM_005271633.4XP_005271690.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X4

      Conserved Domains (4) summary
      cd02665
      Location:141627
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:142
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      cl02553
      Location:141245
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:139377
      UCH; Ubiquitin carboxyl-terminal hydrolase
    22. XM_017018064.1XP_016873553.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X19

    23. XM_017018068.1XP_016873557.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X23

      Related
      ENSP00000442431.1, OTTHUMP00000238296, ENST00000544967.5, OTTHUMT00000398790
    24. XM_011542941.1XP_011541243.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X20

      Conserved Domains (1) summary
      cl02553
      Location:148296
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    25. XM_011542942.1XP_011541244.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X22

      Conserved Domains (1) summary
      cl02553
      Location:57205
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    26. XM_017018069.1XP_016873558.1  ubiquitin carboxyl-terminal hydrolase 28 isoform X24

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      113551888..113629866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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