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    FGF8 fibroblast growth factor 8 [ Homo sapiens (human) ]

    Gene ID: 2253, updated on 6-Jun-2017
    Official Symbol
    FGF8provided by HGNC
    Official Full Name
    fibroblast growth factor 8provided by HGNC
    Primary source
    HGNC:HGNC:3686
    See related
    Ensembl:ENSG00000107831 MIM:600483; Vega:OTTHUMG00000018940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HH6; AIGF; KAL6; FGF-8; HBGF-8
    Summary
    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    10q24.32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (101770130..101780369, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103529887..103540126, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378456 Neighboring gene uncharacterized LOC105378455 Neighboring gene uncharacterized LOC105378458 Neighboring gene uncharacterized LOC105378457 Neighboring gene nucleophosmin/nucleoplasmin 3 Neighboring gene meningioma expressed antigen 5 (hyaluronidase)

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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      Regulation of actin cytoskeleton
    • Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
      Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemThe lipid raft resident adaptor molecules LAT1 and Non-T cell activation linker (NTAL), also known as linker for activation of B cells (LAB)/LAT2 are known participants in the regulation of mast cell...
    • SHC-mediated cascade:FGFR1, organism-specific biosystem (from REACTOME)
      SHC-mediated cascade:FGFR1, organism-specific biosystemThe exact role of SHC1 in FGFR signaling remains unclear. Numerous studies have shown that the p46 and p52 isoforms of SHC1 are phosphorylated in response to FGF stimulation, but direct interaction...
    • SHC-mediated cascade:FGFR2, organism-specific biosystem (from REACTOME)
      SHC-mediated cascade:FGFR2, organism-specific biosystemThe exact role of SHC1 in FGFR signaling remains unclear. Numerous studies have shown that the p46 and p52 isoforms of SHC1 are phosphorylated in response to FGF stimulation, but direct interaction...
    • SHC-mediated cascade:FGFR3, organism-specific biosystem (from REACTOME)
      SHC-mediated cascade:FGFR3, organism-specific biosystemThe exact role of SHC1 in FGFR signaling remains unclear. Numerous studies have shown that the p46 and p52 isoforms of SHC1 are phosphorylated in response to FGF stimulation, but direct interaction...
    • SHC-mediated cascade:FGFR4, organism-specific biosystem (from REACTOME)
      SHC-mediated cascade:FGFR4, organism-specific biosystemThe exact role of SHC1 in FGFR signaling remains unclear. Numerous studies have shown that the p46 and p52 isoforms of SHC1 are phosphorylated in response to FGF stimulation, but direct interaction...
    • SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
      SHC1 events in EGFR signaling, organism-specific biosystemGRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.
    • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
      SOS-mediated signalling, organism-specific biosystemSOS is recruited to the plasma membrane and mediates activation of Ras.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR in disease, organism-specific biosystemA number of skeletal and developmental diseases have been shown to arise as a result of mutations in the FGFR1, 2 and 3 genes. These include dwarfism syndromes (achondroplasia, hypochondroplasia and...
    • Signaling by FGFR1, organism-specific biosystem (from REACTOME)
      Signaling by FGFR1, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR1 in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR1 in disease, organism-specific biosystemThe FGFR1 gene has been shown to be subject to activating mutations, chromosomal rearrangements and gene amplification leading to a variety of proliferative and developmental disorders depending on w...
    • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR2 in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2 in disease, organism-specific biosystemThe FGFR2 gene has been shown to be subject to activating mutations and gene amplification leading to a variety of proliferative and developmental disorders depending on whether these events occur in...
    • Signaling by FGFR3, organism-specific biosystem (from REACTOME)
      Signaling by FGFR3, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR3 in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR3 in disease, organism-specific biosystemThe FGFR3 gene has been shown to be subject to activating mutations and gene amplification leading to a variety of proliferative and developmental disorders depending on whether these events occur in...
    • Signaling by FGFR3 point mutants in cancer, organism-specific biosystem (from REACTOME)
      Signaling by FGFR3 point mutants in cancer, organism-specific biosystemThe FGFR3 gene has been shown to be subject to activating mutations and gene amplification leading to a variety of proliferative and developmental disorders depending on whether these events occur in...
    • Signaling by FGFR4, organism-specific biosystem (from REACTOME)
      Signaling by FGFR4, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by Leptin, organism-specific biosystem (from REACTOME)
      Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
      Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling by activated point mutants of FGFR1, organism-specific biosystem (from REACTOME)
      Signaling by activated point mutants of FGFR1, organism-specific biosystemUnlike FGFR2 and FGFR3, FGFR1 appears not to be a frequent target of activating point mutations (reviewed in Wesche, 2011; Turner and Grose, 2010). Germline point mutations at residue P252 have been...
    • Signaling by activated point mutants of FGFR3, organism-specific biosystem (from REACTOME)
      Signaling by activated point mutants of FGFR3, organism-specific biosystemActivating point mutations in FGFR3 are found in the extracellular ligand-binding domain, the transmembrane region and the tyrosine kinase domain and are believed to result in ligand-independent acti...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Signalling to ERKs, organism-specific biosystem (from REACTOME)
      Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
    • Signalling to RAS, organism-specific biosystem (from REACTOME)
      Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
    • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
      Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
    • Tgif disruption of Shh signaling, organism-specific biosystem (from WikiPathways)
      Tgif disruption of Shh signaling, organism-specific biosystemMutations in the Sonic Hedgehog(SHH) gene result in HPE in humans and mice, and the Shh pathway is targeted by other mutations that cause HPE. HPE is a severe human genetic disease affecting craniofa...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC149376

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    1-phosphatidylinositol-3-kinase activity TAS
    Traceable Author Statement
    more info
     
    Ras guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    chemoattractant activity IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
    Traceable Author Statement
    more info
     
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    MAPK cascade TAS
    Traceable Author Statement
    more info
     
    anatomical structure morphogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    aorta morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in salivary gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration involved in mesendoderm migration IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation in forebrain IEA
    Inferred from Electronic Annotation
    more info
     
    corticotropin hormone secreting cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    dopaminergic neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dopaminergic neuron differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    dorsal/ventral axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial to mesenchymal transition involved in endocardial cushion formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    forebrain dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    gastrulation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    lung morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    male genitalia development IEA
    Inferred from Electronic Annotation
    more info
     
    mesodermal cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    mesonephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    midbrain-hindbrain boundary development IEA
    Inferred from Electronic Annotation
    more info
     
    motor neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    neural plate morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    neuroepithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    odontogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    organ induction IEA
    Inferred from Electronic Annotation
    more info
     
    otic vesicle formation IEA
    Inferred from Electronic Annotation
    more info
     
    outflow tract septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pallium development IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    pharyngeal system development IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
     
    positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phosphatidylinositol 3-kinase signaling TAS
    Traceable Author Statement
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction involved in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    subpallium development IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid-stimulating hormone-secreting cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    fibroblast growth factor 8
    Names
    androgen-induced growth factor
    fibroblast growth factor 8 (androgen-induced)
    heparin-binding growth factor 8

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007151.1 RefSeqGene

      Range
      5069..10941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206389.1NP_001193318.1  fibroblast growth factor 8 isoform G

      See identical proteins and their annotated locations for NP_001193318.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (G) has an alternate 5' exon and lacks an internal segment in the 5' region, compared to variant F. The encoded isoform (G) is shorter at the N-terminus, compared to isoform F.
      Source sequence(s)
      AC010789, CN369230
      Consensus CDS
      CCDS73185.1
      UniProtKB/TrEMBL
      A0A087X1S5
      Related
      ENSP00000484420.1, ENST00000618991.4
      Conserved Domains (1) summary
      pfam00167
      Location:1100
      FGF; Fibroblast growth factor
    2. NM_006119.4NP_006110.1  fibroblast growth factor 8 isoform B precursor

      See identical proteins and their annotated locations for NP_006110.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (B) is shorter than isoform F.
      Source sequence(s)
      AC010789, BC128236, U36223
      Consensus CDS
      CCDS7515.1
      UniProtKB/Swiss-Prot
      P55075
      UniProtKB/TrEMBL
      A1A515
      Related
      ENSP00000321945.2, OTTHUMP00000020348, ENST00000347978.2, OTTHUMT00000049996
      Conserved Domains (1) summary
      pfam00167
      Location:52175
      FGF; Fibroblast growth factor
    3. NM_033163.3NP_149353.1  fibroblast growth factor 8 isoform F precursor

      See identical proteins and their annotated locations for NP_149353.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (F) encodes the longest isoform (F).
      Source sequence(s)
      AC010789, BC069106, BC128236
      Consensus CDS
      CCDS7516.1
      UniProtKB/Swiss-Prot
      P55075
      UniProtKB/TrEMBL
      A1A515
      Related
      ENSP00000321797.2, OTTHUMP00000020349, ENST00000320185.6, OTTHUMT00000049997
      Conserved Domains (1) summary
      pfam00167
      Location:81204
      FGF; Fibroblast growth factor
    4. NM_033164.3NP_149354.1  fibroblast growth factor 8 isoform E precursor

      See identical proteins and their annotated locations for NP_149354.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (E) uses an alternate splice site, compared to variant F. The encoded isoform (E) is shorter than isoform F.
      Source sequence(s)
      AC010789, BC128236, U46213
      Consensus CDS
      CCDS7517.1
      UniProtKB/Swiss-Prot
      P55075
      UniProtKB/TrEMBL
      A1A515
      Related
      ENSP00000340039.3, OTTHUMP00000020351, ENST00000344255.7, OTTHUMT00000049999
      Conserved Domains (1) summary
      pfam00167
      Location:70193
      FGF; Fibroblast growth factor
    5. NM_033165.3NP_149355.1  fibroblast growth factor 8 isoform A precursor

      See identical proteins and their annotated locations for NP_149355.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) lacks an in-frame exon and uses an alternate splice site, compared to variant F. The encoded isoform (A) is shorter than isoform F.
      Source sequence(s)
      AC010789, BC128236
      Consensus CDS
      CCDS7518.1
      UniProtKB/Swiss-Prot
      P55075
      UniProtKB/TrEMBL
      A1A515
      Related
      ENSP00000344306.3, OTTHUMP00000020350, ENST00000346714.7, OTTHUMT00000049998
      Conserved Domains (1) summary
      pfam00167
      Location:41164
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      101770130..101780369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      103813541..103823715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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