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    MYBL2 MYB proto-oncogene like 2 [ Homo sapiens (human) ]

    Gene ID: 4605, updated on 6-Aug-2017
    Official Symbol
    MYBL2provided by HGNC
    Official Full Name
    MYB proto-oncogene like 2provided by HGNC
    Primary source
    HGNC:HGNC:7548
    See related
    Ensembl:ENSG00000101057 MIM:601415; Vega:OTTHUMG00000033062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BMYB; B-MYB
    Summary
    The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
    Orthologs
    Location:
    20q13.12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (43667019..43716496)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42295659..42345136)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 52 Neighboring gene ribosomal protein L27a pseudogene Neighboring gene uncharacterized LOC101927200 Neighboring gene uncharacterized LOC107985441 Neighboring gene gametocyte specific factor 1 like

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • G0 and Early G1, organism-specific biosystem (from REACTOME)
      G0 and Early G1, organism-specific biosystemIn G0 and early G1 in quiescent cells, p130 (RBL2) bound to E2F4 or E2F5 and either DP1 or DP2, associates with the MuvB complex, forming an evolutionarily conserved DREAM complex, that represses tra...
    • G2/M Transition, organism-specific biosystem (from REACTOME)
      G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
    • Gastric Cancer Network 1, organism-specific biosystem (from WikiPathways)
      Gastric Cancer Network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • Polo-like kinase mediated events, organism-specific biosystem (from REACTOME)
      Polo-like kinase mediated events, organism-specific biosystemAt mitotic entry, Plk1 phosphorylates and activates Cdc25C phosphatase, whereas it phosphorylates and down-regulates Wee1A (Watanabe et al. 2004). Plk1 also phosphorylates and inhibits Myt1 activit...
    • TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation, organism-specific biosystem (from REACTOME)
      TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation, organism-specific biosystemDuring retinoic acid-induced cell differentiation, TFAP2A, in complex with NPM1 (nucleophosmin), represses transcription of HSPD1 (Hsp60), NOP2 (p120) and MYBL2 (b-Myb). The repression of gene expres...
    • Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, organism-specific biosystem (from REACTOME)
      Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, organism-specific biosystemThe AP-2 (TFAP2) family of transcription factors includes five proteins in mammals: TFAP2A (AP-2 alpha), TFAP2B (AP-2 beta), TFAP2C (AP-2 gamma), TFAP2D (AP-2 delta) and TFAP2E (AP-2 epsilon). The AP...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC15600

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell cycle TAS
    Traceable Author Statement
    more info
     
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Myb complex IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    myb-related protein B
    Names
    myb-like protein 2
    v-myb avian myeloblastosis viral oncogene homolog-like 2
    v-myb myeloblastosis viral oncogene homolog-like 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278610.1NP_001265539.1  myb-related protein B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA586734, AK303249, AL121886, BC007585, DC395847
      Consensus CDS
      CCDS63276.1
      UniProtKB/Swiss-Prot
      P10244
      Related
      ENSP00000380072.4, ENST00000396863.8
      Conserved Domains (4) summary
      smart00717
      Location:59107
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:59105
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09316
      Location:427570
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:3970
      Myb_DNA-bind_6; Myb-like DNA-binding domain
    2. NM_002466.3NP_002457.1  myb-related protein B isoform 1

      See identical proteins and their annotated locations for NP_002457.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA586734, AL121886, BC007585, DC395847
      Consensus CDS
      CCDS13322.1
      UniProtKB/Swiss-Prot
      P10244
      Related
      ENSP00000217026.4, OTTHUMP00000031719, ENST00000217026.4, OTTHUMT00000080408
      Conserved Domains (4) summary
      smart00717
      Location:83131
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:83129
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09316
      Location:451594
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:3494
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      43667019..43716496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      42199374..42248808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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