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    TRIM29 tripartite motif containing 29 [ Homo sapiens (human) ]

    Gene ID: 23650, updated on 12-Mar-2017
    Official Symbol
    TRIM29provided by HGNC
    Official Full Name
    tripartite motif containing 29provided by HGNC
    Primary source
    HGNC:HGNC:17274
    See related
    Ensembl:ENSG00000137699 MIM:610658; Vega:OTTHUMG00000140377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATDC
    Summary
    The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    11q23.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (120111286..120138179, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119981994..120056237, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369527 Neighboring gene uncharacterized LOC105378956 Neighboring gene uncharacterized LOC105369529 Neighboring gene uncharacterized LOC107984399 Neighboring gene uncharacterized LOC105369530

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke.
    NHGRI GWA Catalog
    Genetic variants near PDGFRA are associated with corneal curvature in Australians.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of tripartite motif containing 29 (TRIM29) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Hematopoietic Stem Cell Differentiation, organism-specific biosystem (from WikiPathways)
      Hematopoietic Stem Cell Differentiation, organism-specific biosystemGrowth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off separately from erythrocytes and megakaryoc...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ36085

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding involved in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    p53 binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    tripartite motif-containing protein 29
    Names
    ataxia-telangiectasia group D-associated protein
    tripartite motif protein TRIM29

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330382.1NP_001317311.1  tripartite motif-containing protein 29 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK299459, AP001360, BM996078, CU450129, DC420658
      Consensus CDS
      CCDS81637.1
      UniProtKB/TrEMBL
      B7Z5V5, E9PRL4
    2. NM_012101.3NP_036233.2  tripartite motif-containing protein 29 isoform 1

      See identical proteins and their annotated locations for NP_036233.2

      Status: REVIEWED

      Source sequence(s)
      AP000679, BC017352
      Consensus CDS
      CCDS8428.1
      UniProtKB/Swiss-Prot
      Q14134
      UniProtKB/TrEMBL
      A0A024R3J1
      Related
      ENSP00000343129, OTTHUMP00000179137, ENST00000341846, OTTHUMT00000277108
      Conserved Domains (2) summary
      smart00336
      Location:220260
      BBOX; B-Box-type zinc finger
      cl02488
      Location:287366
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      120111286..120138179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542732.1XP_011541034.1  tripartite motif-containing protein 29 isoform X2

      Conserved Domains (2) summary
      smart00336
      Location:220258
      BBOX; B-Box-type zinc finger
      cl02488
      Location:287366
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    2. XM_011542729.1XP_011541031.1  tripartite motif-containing protein 29 isoform X1

      See identical proteins and their annotated locations for XP_011541031.1

      Conserved Domains (2) summary
      smart00336
      Location:220258
      BBOX; B-Box-type zinc finger
      cl02488
      Location:287366
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    3. XM_017017454.1XP_016872943.1  tripartite motif-containing protein 29 isoform X5

      Related
      ENSP00000436015, OTTHUMP00000231979, ENST00000529044, OTTHUMT00000388024
    4. XM_017017453.1XP_016872942.1  tripartite motif-containing protein 29 isoform X3

    5. XM_005271490.1XP_005271547.1  tripartite motif-containing protein 29 isoform X6

      See identical proteins and their annotated locations for XP_005271547.1

      UniProtKB/TrEMBL
      B7Z8U9
      Conserved Domains (1) summary
      pfam01442
      Location:1107
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    6. XM_011542733.1XP_011541035.1  tripartite motif-containing protein 29 isoform X4

      Conserved Domains (1) summary
      cl02488
      Location:2099
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      119869439..119896308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_058193.1: Suppressed sequence

      Description
      NM_058193.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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