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    SPRY1 sprouty RTK signaling antagonist 1 [ Homo sapiens (human) ]

    Gene ID: 10252, updated on 4-Jun-2017
    Official Symbol
    SPRY1provided by HGNC
    Official Full Name
    sprouty RTK signaling antagonist 1provided by HGNC
    Primary source
    HGNC:HGNC:11269
    See related
    Ensembl:ENSG00000164056 MIM:602465; Vega:OTTHUMG00000133071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hSPRY1
    Orthologs
    Location:
    4q28.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 4 NC_000004.12 (123396791..123403760)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (124317946..124324915)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 5 Neighboring gene coilin pseudogene 2 Neighboring gene uncharacterized LOC105377404 Neighboring gene transfer RNA-Cys (GCA) 2-1 Neighboring gene long intergenic non-protein coding RNA 2435

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of sprouty homolog 1 protein (SPRY1, antagonist of FGF signaling) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    • EGFR downregulation, organism-specific biosystem (from REACTOME)
      EGFR downregulation, organism-specific biosystemRegulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    bud elongation involved in lung branching IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial to mesenchymal transition involved in cardiac fibroblast development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
     
    metanephros development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neurotrophin TRK receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    organ induction IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    protein sprouty homolog 1
    Names
    sprouty homolog 1, antagonist of FGF signaling
    sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling)
    spry-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258038.1NP_001244967.1  protein sprouty homolog 1

      See identical proteins and their annotated locations for NP_001244967.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest variant. Variants 1-4 encode the same protein.
      Source sequence(s)
      AL602431, AY590694, CA447611, DA765300
      Consensus CDS
      CCDS3731.1
      UniProtKB/Swiss-Prot
      O43609
      Related
      ENSP00000481675.1, ENST00000610581.4
      Conserved Domains (1) summary
      pfam05210
      Location:187284
      Sprouty; Sprouty protein (Spry)
    2. NM_001258039.1NP_001244968.1  protein sprouty homolog 1

      See identical proteins and their annotated locations for NP_001244968.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate promoter, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AV692593, AY590694, CA447611, CN302060
      Consensus CDS
      CCDS3731.1
      UniProtKB/Swiss-Prot
      O43609
      Related
      ENSP00000480540.1, ENST00000622283.1
      Conserved Domains (1) summary
      pfam05210
      Location:187284
      Sprouty; Sprouty protein (Spry)
    3. NM_005841.2NP_005832.1  protein sprouty homolog 1

      See identical proteins and their annotated locations for NP_005832.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate promoter, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC063856, CA447611, DB250100
      Consensus CDS
      CCDS3731.1
      UniProtKB/Swiss-Prot
      O43609
      Related
      ENSP00000377871.2, OTTHUMP00000164086, ENST00000394339.2, OTTHUMT00000256711
      Conserved Domains (1) summary
      pfam05210
      Location:187284
      Sprouty; Sprouty protein (Spry)
    4. NM_199327.2NP_955359.1  protein sprouty homolog 1

      See identical proteins and their annotated locations for NP_955359.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5'UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AL602431, AY192146, AY590694, CA447611
      Consensus CDS
      CCDS3731.1
      UniProtKB/Swiss-Prot
      O43609
      Related
      ENSP00000343785.1, OTTHUMP00000219789, ENST00000339241.1, OTTHUMT00000363944
      Conserved Domains (1) summary
      pfam05210
      Location:187284
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p7 Primary Assembly

      Range
      123396791..123403760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262686.1XP_005262743.1  protein sprouty homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_005262743.1

      UniProtKB/Swiss-Prot
      O43609
      Conserved Domains (1) summary
      pfam05210
      Location:187284
      Sprouty; Sprouty protein (Spry)
    2. XM_017007635.1XP_016863124.1  protein sprouty homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      O43609
      Conserved Domains (1) summary
      pfam05210
      Location:187284
      Sprouty; Sprouty protein (Spry)

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      124294629..124301588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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