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    PPARD peroxisome proliferator activated receptor delta [ Homo sapiens (human) ]

    Gene ID: 5467, updated on 18-Mar-2017
    Official Symbol
    PPARDprovided by HGNC
    Official Full Name
    peroxisome proliferator activated receptor deltaprovided by HGNC
    Primary source
    HGNC:HGNC:9235
    See related
    Ensembl:ENSG00000112033 MIM:600409; Vega:OTTHUMG00000014567
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB
    Summary
    This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
    Orthologs
    Location:
    6p21.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (35342558..35428191)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35310335..35395968)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 76 Neighboring gene DEF6, guanine nucleotide exchange factor Neighboring gene makorin ring finger protein 6, pseudogene Neighboring gene Fanconi anemia complementation group E

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    NHGRI GWA Catalog
    Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
    NHGRI GWA Catalog
    Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
    NHGRI GWA Catalog
    Novel susceptibility genes associated with diabetic cataract in a Taiwanese population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr regulates mitochondrial respiration and enhances the activity of hydroxyacyl-CoA dehydrogenase (HADH) through PPARbeta/delta PubMed
    vpr HIV-1 Vpr enhances PPARbeta/delta-induced PDK4, carnitine palmitoyltransferase I (CPT1), and acetyl-coenzyme A acyltransferase 2 (ACAA2) mRNA expression in cells PubMed
    vpr HIV-1 Vpr enhances PPARbeta/delta agonist GW501516-induced pyruvate dehydrogenase kinase 4 (PDK4) protein expression and phosphorylation of pyruvate dehydrogenase alpha 1 (PDHE1alpha) at serine 293 in cells PubMed
    vpr HIV-1 Vpr physically interacts with the LXXLL motif (residues 64-68) of PPARbeta/delta in vivo and in vitro and enhances PPARbeta/delta-induced transcription activity PubMed

    Go to the HIV-1, Human Interaction Database

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    • Acute myeloid leukemia, conserved biosystem (from KEGG)
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    • Import of palmitoyl-CoA into the mitochondrial matrix, organism-specific biosystem (from REACTOME)
      Import of palmitoyl-CoA into the mitochondrial matrix, organism-specific biosystemThe mitochondrial carnitine system catalyzes the transport of long-chain fatty acids into the mitochondrial matrix where they undergo beta oxidation. This transport system consists of the malonyl-Co...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • NRF2 pathway, organism-specific biosystem (from WikiPathways)
      NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
    • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
      Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...
    • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
      Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
    • Nuclear Receptors in Lipid Metabolism and Toxicity, organism-specific biosystem (from WikiPathways)
      Nuclear Receptors in Lipid Metabolism and Toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
    • PPAR signaling pathway, organism-specific biosystem (from KEGG)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, conserved biosystem (from KEGG)
      PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Presenilin action in Notch and Wnt signaling, organism-specific biosystem (from Pathway Interaction Database)
      Presenilin action in Notch and Wnt signaling, organism-specific biosystem
      Presenilin action in Notch and Wnt signaling
    • Pyruvate metabolism, organism-specific biosystem (from REACTOME)
      Pyruvate metabolism, organism-specific biosystemPyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis, and can be generated by transamination of alanin...
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    • Regulation of pyruvate dehydrogenase (PDH) complex, organism-specific biosystem (from REACTOME)
      Regulation of pyruvate dehydrogenase (PDH) complex, organism-specific biosystemThe mitochondrial pyruvate dehydrogenase (PDH) complex catalyzes the oxidative decarboxylation of pyruvate, linking glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. PDH inactivati...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC3931

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NF-kappaB binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    linoleic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon ensheathment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    decidualization TAS
    Traceable Author Statement
    more info
    PubMed 
    embryo implantation TAS
    Traceable Author Statement
    more info
    PubMed 
    fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
    PubMed 
    fatty acid catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    fatty acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    generation of precursor metabolites and energy TAS
    Traceable Author Statement
    more info
    PubMed 
    glucose metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    glucose transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mRNA transcription IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of collagen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of pri-miRNA transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of blood vessel diameter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epidermis development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fat cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of skeletal muscle tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteoglycan metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of skeletal muscle satellite cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    response to vitamin A IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    vitamin A metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nuclear chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    peroxisome proliferator-activated receptor delta
    Names
    PPAR-beta
    PPAR-delta
    nuclear hormone receptor 1
    nuclear receptor subfamily 1 group C member 2
    peroxisome proliferator-activated nuclear receptor beta/delta variant 2
    peroxisome proliferator-activated receptor beta

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012345.1 RefSeqGene

      Range
      5001..90634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001171818.1NP_001165289.1  peroxisome proliferator-activated receptor delta isoform 1

      See identical proteins and their annotated locations for NP_001165289.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AB099507, AK122614, AL022721, BE503383, DA192442
      Consensus CDS
      CCDS4803.1
      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      A0A024RCW6
      Related
      ENSP00000310928, OTTHUMP00000016256, ENST00000311565, OTTHUMT00000040288
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    2. NM_001171819.1NP_001165290.1  peroxisome proliferator-activated receptor delta isoform 3

      See identical proteins and their annotated locations for NP_001165290.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK122614, AK296425, AL022721, BE503383, DA192442
      Consensus CDS
      CCDS54994.1
      UniProtKB/Swiss-Prot
      Q03181
      Related
      ENSP00000414372, ENST00000448077
      Conserved Domains (2) summary
      cd06932
      Location:134401
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:34117
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    3. NM_001171820.1NP_001165291.1  peroxisome proliferator-activated receptor delta isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AK122614, AK304878, AL022721, BE503383, DA192442
      Consensus CDS
      CCDS54995.1
      UniProtKB/Swiss-Prot
      Q03181
      Related
      ENSP00000413314, ENST00000418635
      Conserved Domains (2) summary
      cd06932
      Location:75342
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cl02596
      Location:4158
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    4. NM_006238.4NP_006229.1  peroxisome proliferator-activated receptor delta isoform 1

      See identical proteins and their annotated locations for NP_006229.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AK122614, BE503383, DA192442
      Consensus CDS
      CCDS4803.1
      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      A0A024RCW6
      Related
      ENSP00000353916, ENST00000360694
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    5. NM_177435.2NP_803184.1  peroxisome proliferator-activated receptor delta isoform 2

      See identical proteins and their annotated locations for NP_803184.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region and 3'UTR. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC002715, CN332566, DA192442, DA476590
      Consensus CDS
      CCDS4804.1
      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      F1D8S7
      Related
      ENSP00000337063, OTTHUMP00000016257, ENST00000337400, OTTHUMT00000040289
      Conserved Domains (2) summary
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      cl11397
      Location:173359
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      35342558..35428191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010974.1XP_016866463.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      A0A024RCW6
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    2. XM_005249193.1XP_005249250.1  peroxisome proliferator-activated receptor delta isoform X1

      See identical proteins and their annotated locations for XP_005249250.1

      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      A0A024RCW6
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    3. XM_017010971.1XP_016866460.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      A0A024RCW6
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    4. XM_011514707.1XP_011513009.1  peroxisome proliferator-activated receptor delta isoform X1

      See identical proteins and their annotated locations for XP_011513009.1

      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      A0A024RCW6
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    5. XM_011514709.1XP_011513011.1  peroxisome proliferator-activated receptor delta isoform X1

      See identical proteins and their annotated locations for XP_011513011.1

      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      A0A024RCW6
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    6. XM_017010972.1XP_016866461.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      A0A024RCW6
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    7. XM_006715120.1XP_006715183.1  peroxisome proliferator-activated receptor delta isoform X1

      See identical proteins and their annotated locations for XP_006715183.1

      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      A0A024RCW6
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    8. XM_011514710.1XP_011513012.1  peroxisome proliferator-activated receptor delta isoform X1

      See identical proteins and their annotated locations for XP_011513012.1

      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      A0A024RCW6
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    9. XM_017010973.1XP_016866462.1  peroxisome proliferator-activated receptor delta isoform X1

      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      A0A024RCW6
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    10. XM_006715123.1XP_006715186.1  peroxisome proliferator-activated receptor delta isoform X1

      See identical proteins and their annotated locations for XP_006715186.1

      UniProtKB/Swiss-Prot
      Q03181
      UniProtKB/TrEMBL
      A0A024RCW6
      Conserved Domains (2) summary
      cd06932
      Location:173440
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    11. XM_017010975.1XP_016866464.1  peroxisome proliferator-activated receptor delta isoform X2

      Conserved Domains (2) summary
      cd06965
      Location:73156
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      cl11397
      Location:173359
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      35312398..35397989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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