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    KIF23 kinesin family member 23 [ Homo sapiens (human) ]

    Gene ID: 9493, updated on 25-May-2017
    Official Symbol
    KIF23provided by HGNC
    Official Full Name
    kinesin family member 23provided by HGNC
    Primary source
    HGNC:HGNC:6392
    See related
    Ensembl:ENSG00000137807 MIM:605064; Vega:OTTHUMG00000172062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHO1; KNSL5; MKLP1; MKLP-1
    Summary
    The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Orthologs
    Location:
    15q23
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (69414246..69448427)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69706585..69740766)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene glucuronic acid epimerase Neighboring gene RNA, 7SL, cytoplasmic 438, pseudogene Neighboring gene uncharacterized LOC102723548 Neighboring gene progestin and adipoQ receptor family member 5 Neighboring gene uncharacterized LOC145694 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 pseudogene Neighboring gene uncharacterized LOC105370876 Neighboring gene ribosomal protein lateral stalk subunit P1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora B signaling, organism-specific biosystem
      Aurora B signaling
    • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
      COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
      Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
      Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
    • Kinesins, organism-specific biosystem (from REACTOME)
      Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
      MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Mitotic Telophase/Cytokinesis, organism-specific biosystem (from REACTOME)
      Mitotic Telophase/Cytokinesis, organism-specific biosystemIn this final phase of mitosis, new membranes are formed around two sets of chromatids and two daughter cells are formed. The chromosomes and the spindle fibers disperse, and the fiber ring around th...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actomyosin contractile ring assembly IEA
    Inferred from Electronic Annotation
    more info
     
    antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
    Traceable Author Statement
    more info
     
    cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule-based movement TAS
    Traceable Author Statement
    more info
     
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle elongation TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic spindle midzone assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plus-end-directed vesicle transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde vesicle-mediated transport, Golgi to ER TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    centralspindlin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    kinesin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    kinesin-like protein KIF23
    Names
    kinesin-like 5 (mitotic kinesin-like protein 1)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042269.1 RefSeqGene

      Range
      5001..39182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001281301.1NP_001268230.1  kinesin-like protein KIF23 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple differences in the coding region compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA291944, AC027237, AK308322, BG939827, DB445953
      Conserved Domains (3) summary
      cl22853
      Location:106324
      Motor_domain; Myosin and Kinesin motor domain
      pfam16540
      Location:683709
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl23720
      Location:447505
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_004856.6NP_004847.2  kinesin-like protein KIF23 isoform 2

      See identical proteins and their annotated locations for NP_004847.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AA291944, AC027237, BC051826, BI093060, DB445953
      Consensus CDS
      CCDS32279.1
      UniProtKB/Swiss-Prot
      Q02241
      Related
      ENSP00000453386.1, OTTHUMP00000247578, ENST00000559279.5, OTTHUMT00000416676
      Conserved Domains (4) summary
      cd01368
      Location:24434
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31436
      Kinesin; Kinesin motor domain
      pfam16540
      Location:700799
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl23720
      Location:557615
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. NM_138555.3NP_612565.1  kinesin-like protein KIF23 isoform 1

      See identical proteins and their annotated locations for NP_612565.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA291944, AC027237, BC017705, DB445953, DR000298
      Consensus CDS
      CCDS32278.1
      UniProtKB/Swiss-Prot
      Q02241
      Related
      ENSP00000260363.4, ENST00000260363.8
      Conserved Domains (4) summary
      cd01368
      Location:24434
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31436
      Kinesin; Kinesin motor domain
      pfam12329
      Location:538611
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
      pfam16540
      Location:804903
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      69414246..69448427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005254796.2XP_005254853.1  kinesin-like protein KIF23 isoform X1

      Conserved Domains (4) summary
      cd01368
      Location:24448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31450
      Kinesin; Kinesin motor domain
      pfam12329
      Location:552625
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
      pfam16540
      Location:818917
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    2. XM_005254797.2XP_005254854.1  kinesin-like protein KIF23 isoform X2

      Conserved Domains (4) summary
      smart00129
      Location:25456
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01368
      Location:24448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam12329
      Location:552625
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
      pfam16540
      Location:818917
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    3. XM_005254798.2XP_005254855.1  kinesin-like protein KIF23 isoform X3

      Conserved Domains (4) summary
      cd01368
      Location:24448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31450
      Kinesin; Kinesin motor domain
      pfam12329
      Location:552625
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
      pfam16540
      Location:807833
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    4. XM_005254799.2XP_005254856.1  kinesin-like protein KIF23 isoform X4

      Conserved Domains (4) summary
      cd01368
      Location:24448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31450
      Kinesin; Kinesin motor domain
      pfam16540
      Location:714813
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl23720
      Location:571629
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    5. XM_017022733.1XP_016878222.1  kinesin-like protein KIF23 isoform X7

    6. XM_011522238.1XP_011520540.1  kinesin-like protein KIF23 isoform X5

      Conserved Domains (3) summary
      cl22853
      Location:106338
      Motor_domain; Myosin and Kinesin motor domain
      pfam12329
      Location:442515
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
      pfam16540
      Location:708807
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    7. XM_011522239.2XP_011520541.1  kinesin-like protein KIF23 isoform X6

      Conserved Domains (3) summary
      cl22853
      Location:1313
      Motor_domain; Myosin and Kinesin motor domain
      pfam16540
      Location:683782
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl23720
      Location:436494
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    8. XM_011522240.1XP_011520542.1  kinesin-like protein KIF23 isoform X8

      Conserved Domains (3) summary
      cl22853
      Location:170
      Motor_domain; Myosin and Kinesin motor domain
      pfam16540
      Location:440539
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl23720
      Location:193251
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      69824574..69858736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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