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    SIRT1 sirtuin 1 [ Homo sapiens (human) ]

    Gene ID: 23411, updated on 21-May-2017
    Official Symbol
    SIRT1provided by HGNC
    Official Full Name
    sirtuin 1provided by HGNC
    Primary source
    HGNC:HGNC:14929
    See related
    Ensembl:ENSG00000096717 MIM:604479; Vega:OTTHUMG00000018340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIR2; SIR2L1; SIR2alpha
    Summary
    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
    Orthologs
    Location:
    10q21.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (67884669..67918390)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (69644427..69678147)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 523, pseudogene Neighboring gene ribosomal protein L12 pseudogene 8 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 4 Neighboring gene ribosomal protein S3a pseudogene 38 Neighboring gene RNA, 7SL, cytoplasmic 220, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of SIRT1 by shRNA enhances HIV-1 transactivation in HIV latency condition, suggesting the direct involvement of SIRT1 to HIV latency PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of SIRT1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
    tat HIV-1 Tat-induced inhibition of SIRT1 activity in TZM-bl cells is reversed by tanshinone II A (a main lipid-soluble monomer derivative from the root of Salvia miltiorrhiza) PubMed
    tat HIV-1 Tat modulates SIRT1 expression in neuron cells PubMed
    tat HIV-1 Tat upregulates miR-182 in TZM-bl cells, which results in downregulation of SIRT1 protein expression and activity by MiR-182 PubMed
    tat HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells PubMed
    tat HIV-1 Tat upregulates miR-34a in TZM-bl cells, which results in downregulation of SIRT1 protein expression and activity and induction of NFkappaB p65 acetylation by MiR-34a PubMed
    tat HIV-1 Tat-induced expression of miR-217 downregulates SIRT1 and promotes HIV-1 LTR transactivation in MAGI cells PubMed
    tat HIV-1 Tat is identified to have a physical interaction with sirtuin 1 (SIRT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    tat Tat causes NAD(+) depletion and inhibits Nicotinamide phosphoribosyltransferase (Nampt) mRNA and protein expression in cells. Nampt is critical in the regulation of Tat-induced inhibition of sirtuin 1 (SIRT1) activity and LTR transactivation PubMed
    tat HIV-1 Tat binds the deacetylase domain (amino acids 341-512) of SIRT1 and inhibits SIRT1 deacetylase activity, which results in the induction of NF-kappaB hyperacetylation PubMed
    tat Overexpression of SIRT1 attenuates Tat-induced HIV-1 transcription in MAGI cells PubMed
    tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed
    tat Deacetylation of HIV-1 Tat by human sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent class III protein deacetylase, regulates Tat transactivation of the HIV-1 promoter PubMed

    Go to the HIV-1, Human Interaction Database

    • AMPK signaling pathway, organism-specific biosystem (from KEGG)
      AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • AMPK signaling pathway, conserved biosystem (from KEGG)
      AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
    • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
      Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Circadian Clock, organism-specific biosystem (from REACTOME)
      Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
    • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
      Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
      Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Glucagon signaling pathway, organism-specific biosystem (from KEGG)
      Glucagon signaling pathway, organism-specific biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
    • Glucagon signaling pathway, conserved biosystem (from KEGG)
      Glucagon signaling pathway, conserved biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
    • HIF-2-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      HIF-2-alpha transcription factor network, organism-specific biosystem
      HIF-2-alpha transcription factor network
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Longevity regulating pathway, organism-specific biosystem (from KEGG)
      Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
    • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
      Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
      Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • Melatonin metabolism and effects, organism-specific biosystem (from WikiPathways)
      Melatonin metabolism and effects, organism-specific biosystemMelatonin is an important regulator of circadian rythmus and influences also insulin secretion, immune function, retinal function and neuroprotection. The synthesis starts with the amino acid tryptop...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • NAD metabolism, sirtuins and aging, organism-specific biosystem (from WikiPathways)
      NAD metabolism, sirtuins and aging, organism-specific biosystemA model for DNA damage, inflammation, NAD+, and aging. Two key events, the activation of PARP by DNA damage and the decreased NAMPT expression associated with inflammation, lead to decreased SIRT1 an...
    • NAD+ biosynthetic pathways, organism-specific biosystem (from WikiPathways)
      NAD+ biosynthetic pathways, organism-specific biosystemNAD+ biosynthetic pathways. NAD+ levels are maintained by three independent pathways. First, the Preiss-Handler pathway uses dietary nicotinic acid and the enzyme nicotinic acid phosphoribosyltransfe...
    • NAD+ metabolism, organism-specific biosystem (from WikiPathways)
      NAD+ metabolism, organism-specific biosystemNAD+ metabolism in different cellular compartments. The different precursors to intracellular NAD metabolism - tryptophan, nicotinic acid (NA), nicotinamide, NR, and NMN - are shown, along with their...
    • Negative epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
      Negative epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2013). About half of the roughl...
    • RORA activates gene expression, organism-specific biosystem (from REACTOME)
      RORA activates gene expression, organism-specific biosystemAs inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.
    • Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Androgen receptor activity, organism-specific biosystem
      Regulation of Androgen receptor activity
    • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
      Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • SIRT1 negatively regulates rRNA Expression, organism-specific biosystem (from REACTOME)
      SIRT1 negatively regulates rRNA Expression, organism-specific biosystemExpression of rRNA genes is coupled to the overall metabolism of the cell by the NAD-dependent histone deacetylase SIRT1, a component of the Energy-dependent Nucleolar Silencing Complex (eNoSC) (Mura...
    • SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystem (from WikiPathways)
      SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystemThis pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär.
    • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class I, organism-specific biosystem
      Signaling events mediated by HDAC Class I
    • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class III, organism-specific biosystem
      Signaling events mediated by HDAC Class III
    • Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystem (from WikiPathways)
      Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystemThis pathway Involved in chemo-resistance of cells in bladder cancer begins with LOXL2 activation of CDC37 and COL2A1. COL2A1 activates the complex NRF1/2 and two other complexes that trigger RTK/MAP...
    • Sterol Regulatory Element-Binding Proteins (SREBP) signalling, organism-specific biosystem (from WikiPathways)
      Sterol Regulatory Element-Binding Proteins (SREBP) signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    HLH domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT NAD+ ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD-dependent histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent histone deacetylase activity (H3-K9 specific) ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NAD-dependent protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent protein deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NAD-dependent protein deacetylase activity TAS
    Traceable Author Statement
    more info
     
    bHLH transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    core promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    keratin filament binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nuclear hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA synthesis involved in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    UV-damage excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    behavioral response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    cell aging TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular triglyceride homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin silencing TAS
    Traceable Author Statement
    more info
    PubMed 
    chromatin silencing at rDNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin silencing at rDNA TAS
    Traceable Author Statement
    more info
     
    circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    establishment of chromatin silencing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fatty acid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    histone H3 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H3 deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3-K9 deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3-K9 modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leptin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    macrophage cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    macrophage differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    maintenance of chromatin silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    methylation-dependent chromatin silencing TAS
    Traceable Author Statement
    more info
    PubMed 
    muscle organ development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cellular response to testosterone stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cellular senescence IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of histone H3-K14 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of histone H3-K9 trimethylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of histone H4-K16 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of prostaglandin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ovulation from ovarian follicle IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-lysine acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-lysine deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MHC class II biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of adaptive immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of adipose tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cAMP-dependent protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cellular senescence IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of chromatin silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone H3-K9 methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of macrophage apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT protein ADP-ribosylation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pyrimidine dimer repair by nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of bile acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of brown fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cellular response to heat TAS
    Traceable Author Statement
    more info
     
    regulation of endodeoxyribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of peroxisome proliferator activated receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein import into nucleus, translocation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of smooth muscle cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to insulin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to leptin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    stress-induced premature senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride mobilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    white fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    colocalizes_with ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    NAD-dependent protein deacetylase sirtuin-1
    Names
    SIR2-like protein 1
    regulatory protein SIR2 homolog 1
    sirtuin type 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050664.1 RefSeqGene

      Range
      5008..38729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142498.1NP_001135970.1  NAD-dependent protein deacetylase sirtuin-1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AA452304, AK289743, BC012499, DB162635
      Consensus CDS
      CCDS44412.1
      UniProtKB/Swiss-Prot
      Q96EB6
      UniProtKB/TrEMBL
      A8K128, E9PC49
      Related
      ENSP00000409208.1, ENST00000432464.5
      Conserved Domains (1) summary
      cl00195
      Location:1194
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    2. NM_001314049.1NP_001300978.1  NAD-dependent protein deacetylase sirtuin-1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses an alternate translation start site compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF235040, AK074805, BC012499, DB162635
      Consensus CDS
      CCDS81469.1
      UniProtKB/Swiss-Prot
      Q96EB6
      UniProtKB/TrEMBL
      B0QZ35
      Related
      ENSP00000384508.1, OTTHUMP00000198112, ENST00000406900.5, OTTHUMT00000048297
      Conserved Domains (1) summary
      cl00195
      Location:12186
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    3. NM_012238.4NP_036370.2  NAD-dependent protein deacetylase sirtuin-1 isoform a

      See identical proteins and their annotated locations for NP_036370.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AA452304, AF083106, BC012499
      Consensus CDS
      CCDS7273.1
      UniProtKB/Swiss-Prot
      Q96EB6
      UniProtKB/TrEMBL
      A0A024QZQ1
      Related
      ENSP00000212015.6, OTTHUMP00000019691, ENST00000212015.10, OTTHUMT00000048296
      Conserved Domains (1) summary
      cd01408
      Location:254489
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      67884669..67918390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      69926404..69960153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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