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    KIR2DL5A killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A [ Homo sapiens (human) ]

    Gene ID: 57292, updated on 25-May-2017
    Official Symbol
    KIR2DL5Aprovided by HGNC
    Official Full Name
    killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5Aprovided by HGNC
    Primary source
    HGNC:HGNC:16345
    See related
    MIM:605305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD158F; KIR2DL5; KIR2DL5.1; KIR2DL5.3
    Summary
    Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
    Annotation information
    Annotation category: only annotated on alternate loci in reference assembly
    See KIR2DL5A in Map Viewer
    Location:
    19p13.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 (ALT_REF_LOCI_35) NT_113949.2 (46835..56299, complement)
    108 current GRCh38.p7 (GCF_000001405.33) 19 (ALT_REF_LOCI_10) NT_187636.1 (60196..69656, complement)
    108 current GRCh38.p7 (GCF_000001405.33) 19 (ALT_REF_LOCI_15) NT_187641.1 (65871..75331, complement)
    108 current GRCh38.p7 (GCF_000001405.33) 19 (ALT_REF_LOCI_18) NT_187644.1 (53906..63370, complement)
    108 current GRCh38.p7 (GCF_000001405.33) 19 (ALT_REF_LOCI_22) NT_187670.1 (53983..63443, complement)
    108 current GRCh38.p7 (GCF_000001405.33) 19 (ALT_REF_LOCI_27) NT_187675.1 (176095..185555)
    108 current GRCh38.p7 (GCF_000001405.33) 19 (ALT_REF_LOCI_2) NW_003571055.2 (450950..460414)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NT_113949.1 (86691..96155)

    NT_187636.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin-like receptor 2DS3 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

    NT_187641.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

    NT_187644.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

    NW_003571055.2Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1

    NT_187670.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

    NT_187675.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin-like receptor 2DS3 allele 0020101 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1

    NT_113949.2Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    killer cell immunoglobulin-like receptor 2DL5A
    Names
    killer cell immunoglobulin-like receptor KIR2DL5A
    killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5
    killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_005994.1 

      Range
      153550..163014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_020535.3NP_065396.1  killer cell immunoglobulin-like receptor 2DL5A precursor

      See identical proteins and their annotated locations for NP_065396.1

      Status: REVIEWED

      Source sequence(s)
      AF204903
      UniProtKB/Swiss-Prot
      Q8N109
      UniProtKB/TrEMBL
      A0A191URI1
      Conserved Domains (2) summary
      smart00410
      Location:3598
      IG_like; Immunoglobulin like
      cl11960
      Location:28117
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 ALT_REF_LOCI_2

    Genomic

    1. NW_003571055.2 Reference GRCh38.p7 ALT_REF_LOCI_2

      Range
      450950..460414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_10

    Genomic

    1. NT_187636.1 Reference GRCh38.p7 ALT_REF_LOCI_10

      Range
      60196..69656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_15

    Genomic

    1. NT_187641.1 Reference GRCh38.p7 ALT_REF_LOCI_15

      Range
      65871..75331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_18

    Genomic

    1. NT_187644.1 Reference GRCh38.p7 ALT_REF_LOCI_18

      Range
      53906..63370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_22

    Genomic

    1. NT_187670.1 Reference GRCh38.p7 ALT_REF_LOCI_22

      Range
      53983..63443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_27

    Genomic

    1. NT_187675.1 Reference GRCh38.p7 ALT_REF_LOCI_27

      Range
      176095..185555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_35

    Genomic

    1. NT_113949.2 Reference GRCh38.p7 ALT_REF_LOCI_35

      Range
      46835..56299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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