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    ANAPC13 anaphase promoting complex subunit 13 [ Homo sapiens (human) ]

    Gene ID: 25847, updated on 5-Nov-2017
    Official Symbol
    ANAPC13provided by HGNC
    Official Full Name
    anaphase promoting complex subunit 13provided by HGNC
    Primary source
    HGNC:HGNC:24540
    See related
    Ensembl:ENSG00000129055 MIM:614484; Vega:OTTHUMG00000159803
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SWM1; APC13
    Summary
    This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]
    Orthologs
    Location:
    3q22.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (134477704..134486023, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (134196546..134204865, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosome binding domain 1 pseudogene Neighboring gene high mobility group box 3 pseudogene 13 Neighboring gene microRNA 4788 Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene centrosomal protein 63 Neighboring gene kyphoscoliosis peptidase

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016
    • APC/C complex, organism-specific biosystem (from KEGG)
      APC/C complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • APC/C complex, conserved biosystem (from KEGG)
      APC/C complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp566D193

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    anaphase-promoting complex subunit 13
    Names
    cyclosome subunit 13

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242374.1NP_001229303.1  anaphase-promoting complex subunit 13

      See identical proteins and their annotated locations for NP_001229303.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC010207, AK290761, AV682398, BU627217
      Consensus CDS
      CCDS3085.1
      UniProtKB/Swiss-Prot
      Q9BS18
      UniProtKB/TrEMBL
      A8K3Z6
      Related
      ENSP00000421842.1, OTTHUMP00000216544, ENST00000510994.5, OTTHUMT00000357412
      Conserved Domains (1) summary
      pfam05839
      Location:174
      Apc13p; Apc13p protein
    2. NM_001242375.1NP_001229304.1  anaphase-promoting complex subunit 13

      See identical proteins and their annotated locations for NP_001229304.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC010207, AV682398, BU627217, CN258858
      Consensus CDS
      CCDS3085.1
      UniProtKB/Swiss-Prot
      Q9BS18
      UniProtKB/TrEMBL
      A8K3Z6
      Related
      ENSP00000427327.1, OTTHUMP00000216545, ENST00000514612.5, OTTHUMT00000357414
      Conserved Domains (1) summary
      pfam05839
      Location:174
      Apc13p; Apc13p protein
    3. NM_015391.3NP_056206.1  anaphase-promoting complex subunit 13

      See identical proteins and their annotated locations for NP_056206.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK026550, BC005398, BG428689, BU852706
      Consensus CDS
      CCDS3085.1
      UniProtKB/Swiss-Prot
      Q9BS18
      UniProtKB/TrEMBL
      A8K3Z6
      Related
      ENSP00000346987.5, OTTHUMP00000216546, ENST00000354910.9, OTTHUMT00000357415
      Conserved Domains (1) summary
      pfam05839
      Location:174
      Apc13p; Apc13p protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      134477704..134486023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      134160900..134169219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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