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    DKK1 dickkopf WNT signaling pathway inhibitor 1 [ Homo sapiens (human) ]

    Gene ID: 22943, updated on 25-May-2017
    Official Symbol
    DKK1provided by HGNC
    Official Full Name
    dickkopf WNT signaling pathway inhibitor 1provided by HGNC
    Primary source
    HGNC:HGNC:2891
    See related
    Ensembl:ENSG00000107984 MIM:605189; Vega:OTTHUMG00000018247
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SK; DKK-1
    Summary
    This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    10q21.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (52314281..52317657)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (54074041..54077417)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene protein kinase, cGMP-dependent, type I Neighboring gene cleavage stimulation factor subunit 2 tau variant Neighboring gene PRKG1 antisense RNA 1 Neighboring gene ribosomal protein L31 pseudogene 44 Neighboring gene THAP domain containing 12 pseudogene 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
    NHGRI GWA Catalog
    Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.
    NHGRI GWA Catalog
    Genome-wide association study of chronic periodontitis in a general German population.
    NHGRI GWA Catalog
    Several common variants modulate heart rate, PR interval and QRS duration.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of dickkopf-1 in primary human osteoblasts PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    co-receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    co-receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    growth factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    low-density lipoprotein particle receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor antagonist activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transducer activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway involved in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell morphogenesis involved in differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic limb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    endoderm formation IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    face morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    learning or memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    limb development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mesoderm formation IEA
    Inferred from Electronic Annotation
    more info
     
    modulation of age-related behavioral decline ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    motor learning IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of Wnt-Frizzled-LRP5/6 complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of Wnt-Frizzled-LRP5/6 complex assembly IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    negative regulation of Wnt-Frizzled-LRP5/6 complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cardiac muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mesodermal cell fate specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of ossification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of pathway-restricted SMAD protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of Wnt signaling pathway, calcium modulating pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of Wnt signaling pathway, planar cell polarity pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell death TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of midbrain dopaminergic neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of tau-protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of dopaminergic neuron differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of endodermal cell fate specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of synapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    synapse disassembly TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    early endosome membrane TAS
    Traceable Author Statement
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    dickkopf-related protein 1
    Names
    dickkopf 1 homolog
    dickkopf-1 like
    dickkopf-like protein 1
    hDkk-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012242.2NP_036374.1  dickkopf-related protein 1 precursor

      See identical proteins and their annotated locations for NP_036374.1

      Status: REVIEWED

      Source sequence(s)
      AC009986, AF127563, BU752259, BX952450
      Consensus CDS
      CCDS7246.1
      UniProtKB/Swiss-Prot
      O94907
      UniProtKB/TrEMBL
      I1W660
      Related
      ENSP00000363081.3, OTTHUMP00000019617, ENST00000373970.3, OTTHUMT00000048100
      Conserved Domains (1) summary
      pfam04706
      Location:85139
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      52314281..52317657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      54355855..54359231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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