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    TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 [ Homo sapiens (human) ]

    Gene ID: 7073, updated on 19-May-2018
    Official Symbol
    TIAL1provided by HGNC
    Official Full Name
    TIA1 cytotoxic granule associated RNA binding protein like 1provided by HGNC
    Primary source
    HGNC:HGNC:11804
    See related
    Ensembl:ENSG00000151923 MIM:603413; Vega:OTTHUMG00000019156
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCBP; TIAR
    Summary
    The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 14.6), lymph node (RPKM 14.0) and 25 other tissues See more
    Orthologs
    See TIAL1 in Genome Data Viewer
    Location:
    10q26.11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (119573465..119598841, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121332977..121356541, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene microRNA 4681 Neighboring gene regulator of G protein signaling 10 Neighboring gene uncharacterized LOC105378512 Neighboring gene RAD1 pseudogene 1 Neighboring gene ribosomal protein S8 pseudogene 4

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag co-localizes and interacts with G3BP1 and TIAR to modulate stress granule assembly during HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    • FGFR2 alternative splicing, organism-specific biosystem (from REACTOME)
      FGFR2 alternative splicing, organism-specific biosystemAlternative splicing of the FGFR2 nascent mRNA generates an epithelial specific isoform (FGFR2 IIIb) and a mesenchymal specific isoform (FGFR2 IIIc). The inclusion of exon 8 in FGFR2 IIIb or exon 9 ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC33401

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    AU-rich element binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    germ cell development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    stem cell division IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lysosome TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    nucleolysin TIAR
    Names
    T-cluster binding protein
    TIA-1-related nucleolysin
    aging-associated gene 7 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029240.1 RefSeqGene

      Range
      5001..28565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001033925.1NP_001029097.1  nucleolysin TIAR isoform 2

      See identical proteins and their annotated locations for NP_001029097.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a longer protein (isoform 2).
      Source sequence(s)
      AA972022, AC012468, AK125264, BC030025, M96954
      Consensus CDS
      CCDS31295.1
      UniProtKB/Swiss-Prot
      Q01085
      UniProtKB/TrEMBL
      Q49AS9
      Related
      ENSP00000358089.2, OTTHUMP00000020602, ENST00000369093.6, OTTHUMT00000050668
      Conserved Domains (3) summary
      cd12616
      Location:10107
      RRM1_TIAR; RNA recognition motif 1 in nucleolysin TIAR and similar proteins
      cd12617
      Location:113192
      RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
      cd12620
      Location:222294
      RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    2. NM_001323964.1NP_001310893.1  nucleolysin TIAR isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform 3.
      Source sequence(s)
      AC012468, BC030025
      UniProtKB/TrEMBL
      Q49AS9
      Conserved Domains (2) summary
      cd12620
      Location:82154
      RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
      cl17169
      Location:252
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_001323965.1NP_001310894.1  nucleolysin TIAR isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform 3.
      Source sequence(s)
      AC012468
      UniProtKB/TrEMBL
      Q49AS9
      Conserved Domains (2) summary
      cd12620
      Location:82154
      RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
      cl17169
      Location:252
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. NM_001323967.1NP_001310896.1  nucleolysin TIAR isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform 3.
      Source sequence(s)
      AC012468
      UniProtKB/TrEMBL
      Q49AS9
      Conserved Domains (2) summary
      cd12620
      Location:82154
      RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
      cl17169
      Location:252
      RRM_SF; RNA recognition motif (RRM) superfamily
    5. NM_001323968.1NP_001310897.1  nucleolysin TIAR isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC012468
    6. NM_001323969.1NP_001310898.1  nucleolysin TIAR isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC012468
      Conserved Domains (3) summary
      cd12617
      Location:57136
      RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
      cd12620
      Location:166238
      RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
      cl17169
      Location:151
      RRM_SF; RNA recognition motif (RRM) superfamily
    7. NM_001323970.1NP_001310899.1  nucleolysin TIAR isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC012468, BC128140
      Conserved Domains (3) summary
      cd12617
      Location:74153
      RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
      cd12620
      Location:183255
      RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
      cl17169
      Location:1968
      RRM_SF; RNA recognition motif (RRM) superfamily
    8. NM_003252.3NP_003243.1  nucleolysin TIAR isoform 1

      See identical proteins and their annotated locations for NP_003243.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AA972022, AC012468, AK125264, AL833106, BC030025
      Consensus CDS
      CCDS7613.1
      UniProtKB/Swiss-Prot
      Q01085
      UniProtKB/TrEMBL
      Q49AS9
      Related
      ENSP00000394902.2, OTTHUMP00000020605, ENST00000436547.6, OTTHUMT00000050672
      Conserved Domains (3) summary
      cd12616
      Location:1090
      RRM1_TIAR; RNA recognition motif 1 in nucleolysin TIAR and similar proteins
      cd12617
      Location:96175
      RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
      cd12620
      Location:205277
      RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins

    RNA

    1. NR_136661.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012468, AL833106, BC030025
    2. NR_136662.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012468
    3. NR_136663.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012468, D64015

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      119573465..119598841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448151.1XP_024303919.1  nucleolysin TIAR isoform X1

      Conserved Domains (3) summary
      cd12617
      Location:74153
      RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
      cd12620
      Location:183255
      RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
      cl17169
      Location:1968
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. XR_945808.2 RNA Sequence

    2. XR_001747195.2 RNA Sequence

    3. XR_001747194.2 RNA Sequence

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