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    PLK1 polo like kinase 1 [ Homo sapiens (human) ]

    Gene ID: 5347, updated on 17-Sep-2017
    Official Symbol
    PLK1provided by HGNC
    Official Full Name
    polo like kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:9077
    See related
    Ensembl:ENSG00000166851 MIM:602098; Vega:OTTHUMG00000096984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLK; STPK13
    Summary
    The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    16p12.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (23678772..23690367)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23690201..23701688)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene partner and localizer of BRCA2 Neighboring gene dynactin subunit 5 Neighboring gene endoplasmic reticulum to nucleus signaling 2 Neighboring gene calcineurin like EF-hand protein 2 Neighboring gene protein kinase C beta Neighboring gene uncharacterized LOC105371141

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of polo-like kinase 1 (PLK1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with PLK1 PubMed
    Tat tat HIV-1 Tat forms a quaternary complex with Tip60, Plk1, and cyclin B1 to inhibit Plk1-mediated phosphorylation of cyclin B1 at Ser133 position PubMed
    tat HIV-1 Tat directly interacts with Plk1 through the kinase (residues 53-305) and the polo-box (residues 417-480) domains of Plk1 PubMed
    Vpr vpr HIV-1 Vpr R80A mutant demonstrates decreased or absent TNF production from MT4C5 cells suggesting that PLK1-Vpr interaction affects TNF production from HIV-1 infected cells PubMed
    vpr HIV-1 Vpr causes increased levels of CyclinB1, Plk1, and Cdk1 in a complex with the nuclear transport and spindle assembly protein, importin beta PubMed
    Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein polo-like kinase 1 (PLK1) PubMed

    Go to the HIV-1, Human Interaction Database

    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
      APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemFrom late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Gemin...
    • AURKA Activation by TPX2, organism-specific biosystem (from REACTOME)
      AURKA Activation by TPX2, organism-specific biosystemTPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. ...
    • Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemAPC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein ...
    • Activation of NIMA Kinases NEK9, NEK6, NEK7, organism-specific biosystem (from REACTOME)
      Activation of NIMA Kinases NEK9, NEK6, NEK7, organism-specific biosystemNEK6 and NEK7 are activated during mitosis by another NIMA family kinase, NEK9 (Belham et al. 2003, Richards et al. 2009), which is activated by CDK1- and PLK1-mediated phosphorylation (Roig et al. 2...
    • Anchoring of the basal body to the plasma membrane, organism-specific biosystem (from REACTOME)
      Anchoring of the basal body to the plasma membrane, organism-specific biosystemCilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core su...
    • Cell Cycle, organism-specific biosystem (from WikiPathways)
      Cell Cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Centrosome maturation, organism-specific biosystem (from REACTOME)
      Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
    • Cilium Assembly, organism-specific biosystem (from REACTOME)
      Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
    • Condensation of Prophase Chromosomes, organism-specific biosystem (from REACTOME)
      Condensation of Prophase Chromosomes, organism-specific biosystemIn mitotic prophase, the action of the condensin II complex enables initial chromosome condensation.The condensin II complex subunit NCAPD3 binds monomethylated histone H4 (H4K20me1), thereby associa...
    • Cyclin A/B1 associated events during G2/M transition, organism-specific biosystem (from REACTOME)
      Cyclin A/B1 associated events during G2/M transition, organism-specific biosystemCell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions. The G2/M transition is regulated through the phosphorylation of nuclear lamins and h...
    • FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXM1 transcription factor network, organism-specific biosystem
      FOXM1 transcription factor network
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • G2/M Transition, organism-specific biosystem (from REACTOME)
      G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
    • Golgi Cisternae Pericentriolar Stack Reorganization, organism-specific biosystem (from REACTOME)
      Golgi Cisternae Pericentriolar Stack Reorganization, organism-specific biosystemThe pericentriolar stacks of Golgi cisternae undergo extensive fragmentation and reorganization in mitosis. In mammalian cells, Golgi apparatus consists of stacked cisternae that are connected by tu...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Integrated Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Cancer Pathway, organism-specific biosystem
      Integrated Cancer Pathway
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Loss of Nlp from mitotic centrosomes, organism-specific biosystem (from REACTOME)
      Loss of Nlp from mitotic centrosomes, organism-specific biosystemDuring interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated...
    • Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystem (from REACTOME)
      Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystemIn addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization ...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
    • Mitotic Metaphase/Anaphase Transition, organism-specific biosystem (from REACTOME)
      Mitotic Metaphase/Anaphase Transition, organism-specific biosystemThe metaphase to anaphase transition during mitosis is triggered by the destruction of mitotic cyclins.
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
    • Mitotic Prophase, organism-specific biosystem (from REACTOME)
      Mitotic Prophase, organism-specific biosystemDuring prophase, the chromatin in the nucleus condenses, and the nucleolus disappears. Centrioles begin moving to the opposite poles or sides of the cell. Some of the fibers that extend from the cen...
    • Mitotic Telophase/Cytokinesis, organism-specific biosystem (from REACTOME)
      Mitotic Telophase/Cytokinesis, organism-specific biosystemIn this final phase of mitosis, new membranes are formed around two sets of chromatids and two daughter cells are formed. The chromosomes and the spindle fibers disperse, and the fiber ring around th...
    • Nuclear Envelope Breakdown, organism-specific biosystem (from REACTOME)
      Nuclear Envelope Breakdown, organism-specific biosystemThe nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelo...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK1 signaling events, organism-specific biosystem
      PLK1 signaling events
    • Phosphorylation of Emi1, organism-specific biosystem (from REACTOME)
      Phosphorylation of Emi1, organism-specific biosystemThe phosphorylation of Emi1, which is required for its degradation in mitosis, appears to involve both Plk1 and Cdk1.
    • Phosphorylation of the APC/C, organism-specific biosystem (from REACTOME)
      Phosphorylation of the APC/C, organism-specific biosystemPhosphorylation of APC subunits is required for Cdc20 mediated activation by of the APC/C at the metaphase anaphase transition (Kramer et al., 2000). While the kinases responsible for phosphorylation...
    • Polo-like kinase mediated events, organism-specific biosystem (from REACTOME)
      Polo-like kinase mediated events, organism-specific biosystemAt mitotic entry, Plk1 phosphorylates and activates Cdc25C phosphatase, whereas it phosphorylates and down-regulates Wee1A (Watanabe et al. 2004). Plk1 also phosphorylates and inhibits Myt1 activit...
    • Polo-like kinase signaling events in the cell cycle, organism-specific biosystem (from Pathway Interaction Database)
      Polo-like kinase signaling events in the cell cycle, organism-specific biosystem
      Polo-like kinase signaling events in the cell cycle
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
    • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
      Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...
    • Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
      Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemThe APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zacha...
    • Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
      Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalyticall...
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Regulation of toll-like receptor signaling pathway, organism-specific biosystem
      Regulation of toll-like receptor signaling pathway
    • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
      Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
    • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
      Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...
    • The role of GTSE1 in G2/M progression after G2 checkpoint, organism-specific biosystem (from REACTOME)
      The role of GTSE1 in G2/M progression after G2 checkpoint, organism-specific biosystemGTSE1 (B99) was identified as a microtubule-associated protein product of the mouse B99 gene, which exhibits both a cell cycle regulated expression, with highest levels in G2, and DNA damage triggere...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anaphase-promoting complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase activity TAS
    Traceable Author Statement
    more info
     
    magnesium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    G2 DNA damage checkpoint IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    anaphase-promoting complex-dependent catabolic process TAS
    Traceable Author Statement
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ciliary basal body-plasma membrane docking TAS
    Traceable Author Statement
    more info
     
    cytokinesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female meiosis chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    homologous chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic nuclear envelope disassembly TAS
    Traceable Author Statement
    more info
     
    mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear envelope disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein localization to nucleus TAS
    Traceable Author Statement
    more info
     
    positive regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
     
    positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
    Traceable Author Statement
    more info
     
    positive regulation of ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
     
    regulation of G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    regulation of cell cycle TAS
    Traceable Author Statement
    more info
     
    regulation of cell cycle G2/M phase transition TAS
    Traceable Author Statement
    more info
     
    regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    sister chromatid cohesion TAS
    Traceable Author Statement
    more info
     
    synaptonemal complex disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    condensed nuclear chromosome outer kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptonemal complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    serine/threonine-protein kinase PLK1
    Names
    PLK-1
    cell cycle regulated protein kinase
    polo (Drosophia)-like kinase
    serine/threonine-protein kinase 13
    NP_005021.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005030.5NP_005021.2  serine/threonine-protein kinase PLK1

      See identical proteins and their annotated locations for NP_005021.2

      Status: REVIEWED

      Source sequence(s)
      BC014846, DC300189
      Consensus CDS
      CCDS10616.1
      UniProtKB/Swiss-Prot
      P53350
      Related
      ENSP00000300093.4, OTTHUMP00000122462, ENST00000300093.8, OTTHUMT00000214057
      Conserved Domains (3) summary
      cd13117
      Location:509590
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:407494
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14187
      Location:45309
      STKc_PLK1; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      23678772..23690367
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      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      24701812..24713407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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