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    YAP1 Yes associated protein 1 [ Homo sapiens (human) ]

    Gene ID: 10413, updated on 25-May-2017
    Official Symbol
    YAP1provided by HGNC
    Official Full Name
    Yes associated protein 1provided by HGNC
    Primary source
    HGNC:HGNC:16262
    See related
    Ensembl:ENSG00000137693 MIM:606608; Vega:OTTHUMG00000167322
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YAP; YKI; COB1; YAP2; YAP65
    Summary
    This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
    Orthologs
    Location:
    11q22.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (102109957..102233423)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (101981151..102104154)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene centrosomal protein 126 Neighboring gene proline rich 21 pseudogene Neighboring gene chromosome 11 open reading frame 70 Neighboring gene uncharacterized LOC105369460 Neighboring gene ribosomal protein S6 pseudogene 17

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation
    MedGen: C1852750 OMIM: 120433 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2014-11-13)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated (2014-11-13)

    ClinGen Genome Curation PagePubMed

    NHGRI GWAS Catalog

    Description
    Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
    NHGRI GWA Catalog
    Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
    NHGRI GWA Catalog
    Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
    NHGRI GWA Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    NHGRI GWA Catalog
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    • Hippo signaling, organism-specific biosystem (from KEGG)
      Hippo signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • Hippo signaling, conserved biosystem (from KEGG)
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    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway -multiple species, organism-specific biosystem (from KEGG)
      Hippo signaling pathway -multiple species, organism-specific biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
    • Hippo signaling pathway -multiple species, conserved biosystem (from KEGG)
      Hippo signaling pathway -multiple species, conserved biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
    • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
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    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
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      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
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    • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
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    • Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystem (from WikiPathways)
      Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystemRac1/p38 pathway from Ingenuity Pathway Analysis.
    • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by Hippo, organism-specific biosystem (from REACTOME)
      Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...
    • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
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    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling
    • YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystem (from REACTOME)
      YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystemYAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 intera...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II core promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    proline-rich region binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, RNA polymerase II transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    bud elongation involved in lung branching IEA
    Inferred from Electronic Annotation
    more info
     
    cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to gamma radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    contact inhibition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryonic heart tube morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    hippo signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    lateral mesoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    lung epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of nucleic acid-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    notochord development IEA
    Inferred from Electronic Annotation
    more info
     
    paraxial mesoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of metanephric nephron tubule epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neurogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    TEAD-1-YAP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    TEAD-2-YAP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    transcriptional coactivator YAP1
    Names
    65 kDa Yes-associated protein
    protein yorkie homolog
    yes-associated protein 1
    yes-associated protein 2
    yes-associated protein YAP65 homolog
    yorkie homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029530.1 RefSeqGene

      Range
      5001..127963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130145.2NP_001123617.1  transcriptional coactivator YAP1 isoform 1

      See identical proteins and their annotated locations for NP_001123617.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 9. The encoded protein (isoform 1) represents the YAP1-2gamma isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
      Source sequence(s)
      AI128142, AL832620, AP000942, AP001527, BC038235
      Consensus CDS
      CCDS44716.1
      UniProtKB/Swiss-Prot
      P46937
      UniProtKB/TrEMBL
      Q86T74
      Related
      ENSP00000282441.5, OTTHUMP00000235695, ENST00000282441.9, OTTHUMT00000394151
      Conserved Domains (2) summary
      smart00456
      Location:231263
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:174203
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    2. NM_001195044.1NP_001181973.1  transcriptional coactivator YAP1 isoform 3

      See identical proteins and their annotated locations for NP_001181973.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate exon in the 3' coding region, compared to variant 9. The encoded protein (isoform 3) represents the YAP1-2alpha isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
      Source sequence(s)
      AI128142, AL832620, AP000942, AP001527, AY316529
      Consensus CDS
      CCDS53699.1
      UniProtKB/Swiss-Prot
      P46937
      UniProtKB/TrEMBL
      Q86T74
      Related
      ENSP00000431574.1, OTTHUMP00000235696, ENST00000531439.5, OTTHUMT00000394152
      Conserved Domains (2) summary
      smart00456
      Location:231263
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:174203
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    3. NM_001195045.1NP_001181974.1  transcriptional coactivator YAP1 isoform 4

      See identical proteins and their annotated locations for NP_001181974.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, compared to variant 9. These differences cause translation initiation at a downstream AUG and result in a shorter isoform (4), compared to isoform 9.
      Source sequence(s)
      AA854862, AI128142, AK316116, AL832620, AP000942, BC038235
      Consensus CDS
      CCDS53700.1
      UniProtKB/Swiss-Prot
      P46937
      UniProtKB/TrEMBL
      Q86T74
      Related
      ENSP00000435602.1, OTTHUMP00000235697, ENST00000524575.5, OTTHUMT00000394153
      Conserved Domains (2) summary
      smart00456
      Location:5385
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:125
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    4. NM_001282097.1NP_001269026.1  transcriptional coactivator YAP1 isoform 6

      See identical proteins and their annotated locations for NP_001269026.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 9. The encoded protein (isoform 6) represents the YAP1-1gamma isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
      Source sequence(s)
      AB567720, AI128142, AL832620, AP000942, AP001527, BC026212
      UniProtKB/Swiss-Prot
      P46937
      UniProtKB/TrEMBL
      Q86T74
      Conserved Domains (1) summary
      cd00201
      Location:174203
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    5. NM_001282098.1NP_001269027.1  transcriptional coactivator YAP1 isoform 5

      See identical proteins and their annotated locations for NP_001269027.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region, compared to variant 9. The encoded protein (isoform 5) represents the YAP1-1beta isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
      Source sequence(s)
      AI128142, AL832620, AP000942, AP001527, BC026212, BC038235, HE864159
      Consensus CDS
      CCDS60945.1
      UniProtKB/Swiss-Prot
      P46937
      UniProtKB/TrEMBL
      A0A024R3E4, Q86T74
      Related
      ENSP00000487519.1, OTTHUMP00000278710, ENST00000629586.2, OTTHUMT00000482753
      Conserved Domains (1) summary
      cd00201
      Location:174203
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    6. NM_001282099.1NP_001269028.1  transcriptional coactivator YAP1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon in the coding region, compared to variant 9. The encoded protein (isoform 7) represents the YAP1-1delta isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
      Source sequence(s)
      AI128142, AL832620, AP000942, AP001527, BC026212, BC038235, HE864161
      Consensus CDS
      CCDS73374.1
      UniProtKB/Swiss-Prot
      P46937
      UniProtKB/TrEMBL
      Q86T74
      Related
      ENSP00000331023.4, ENST00000345877.6
      Conserved Domains (1) summary
      cd00201
      Location:174203
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    7. NM_001282100.1NP_001269029.1  transcriptional coactivator YAP1 isoform 8

      See identical proteins and their annotated locations for NP_001269029.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate in-frame exon in the 3' coding region, compared to variant 9. The encoded protein (isoform 8) represents the YAP1-2beta isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
      Source sequence(s)
      AB567720, AI128142, AL832620, AP000942, AP001527, BC026212, BC038235, HE864162
      Consensus CDS
      CCDS60944.1
      UniProtKB/Swiss-Prot
      P46937
      UniProtKB/TrEMBL
      Q86T74
      Related
      ENSP00000445635.1, ENST00000537274.5
      Conserved Domains (2) summary
      smart00456
      Location:231263
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:174203
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    8. NM_001282101.1NP_001269030.1  transcriptional coactivator YAP1 isoform 9

      See identical proteins and their annotated locations for NP_001269030.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) represents the longest transcript and encodes the longest isoform (9). The encoded protein represents the YAP1-2delta isoform described in Figure 3 of PMID: 22939869.
      Source sequence(s)
      AI128142, AL832620, AP000942, AP001527, BC026212, BC038235, HE864163
      Consensus CDS
      CCDS73373.1
      UniProtKB/Swiss-Prot
      P46937
      UniProtKB/TrEMBL
      K0KVU2, Q86T74
      Related
      ENSP00000478927.1, ENST00000615667.4
      Conserved Domains (2) summary
      smart00456
      Location:231263
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:174203
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    9. NM_006106.4NP_006097.2  transcriptional coactivator YAP1 isoform 2

      See identical proteins and their annotated locations for NP_006097.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks two alternate exons in the coding region, compared to variant 9. The encoded protein (isoform 2) represents the YAP1-1alpha isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
      Source sequence(s)
      AI128142, AL832620, AP000942, AP001527, AP002777
      Consensus CDS
      CCDS8314.2
      UniProtKB/TrEMBL
      Q86T74
      Related
      ENSP00000434134.1, OTTHUMP00000235694, ENST00000526343.5, OTTHUMT00000394150
      Conserved Domains (1) summary
      cd00201
      Location:174203
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      102109957..102233423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271378.3XP_005271435.1  transcriptional coactivator YAP1 isoform X1

      Conserved Domains (2) summary
      smart00456
      Location:231263
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:174203
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    2. XM_005271380.3XP_005271437.1  transcriptional coactivator YAP1 isoform X2

      See identical proteins and their annotated locations for XP_005271437.1

      Conserved Domains (2) summary
      smart00456
      Location:231263
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:174203
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    3. XM_005271383.3XP_005271440.1  transcriptional coactivator YAP1 isoform X4

      See identical proteins and their annotated locations for XP_005271440.1

      Conserved Domains (2) summary
      smart00456
      Location:231263
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:174203
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    4. XM_005271381.3XP_005271438.1  transcriptional coactivator YAP1 isoform X3

      Conserved Domains (2) summary
      smart00456
      Location:231263
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:174203
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    5. XM_011542556.2XP_011540858.1  transcriptional coactivator YAP1 isoform X6

      See identical proteins and their annotated locations for XP_011540858.1

      Conserved Domains (2) summary
      smart00456
      Location:5385
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:125
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    6. XM_017017093.1XP_016872582.1  transcriptional coactivator YAP1 isoform X7

      Conserved Domains (2) summary
      smart00456
      Location:5385
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:125
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    7. XM_011542555.2XP_011540857.1  transcriptional coactivator YAP1 isoform X5

      See identical proteins and their annotated locations for XP_011540857.1

      Conserved Domains (2) summary
      smart00456
      Location:5385
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:125
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      101864181..101987123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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