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    ARHGAP32 Rho GTPase activating protein 32 [ Homo sapiens (human) ]

    Gene ID: 9743, updated on 5-Nov-2017
    Official Symbol
    ARHGAP32provided by HGNC
    Official Full Name
    Rho GTPase activating protein 32provided by HGNC
    Primary source
    HGNC:HGNC:17399
    See related
    Ensembl:ENSG00000134909 MIM:608541; Vega:OTTHUMG00000165774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRIT; RICS; GC-GAP; PX-RICS; p250GAP; p200RhoGAP
    Summary
    RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in brain (RPKM 12.5), esophagus (RPKM 7.8) and 22 other tissues See more
    Orthologs
    Location:
    11q24.3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (128965060..129279168, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (128834955..129062093, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 45 Neighboring gene potassium voltage-gated channel subfamily J member 5 Neighboring gene tumor protein p53 regulated apoptosis inducing protein 1 Neighboring gene RNA, U6 small nuclear 876, pseudogene Neighboring gene RNA, U6 small nuclear 874, pseudogene Neighboring gene uncharacterized LOC105369571 Neighboring gene zinc finger protein 123, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of Rho GTPase activating protein 32 (ARHGAP32; RICS) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC1892, KIAA0712

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    GTPase activator activity TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    rho GTPase-activating protein 32
    Names
    GAB-associated CDC42
    GAB-associated Cdc42/Rac GTPase-activating protein
    GTPase regulator interacting with TrkA
    GTPase-activating protein for Cdc42 and Rac1
    RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaling
    brain-specific Rho GTP-ase-activating protein
    brain-specific Rho GTPase-activating protein
    rac GTPase activating protein
    rho-type GTPase-activating protein 32
    rho/Cdc42/Rac GTPase-activating protein RICS
    rhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142685.1NP_001136157.1  rho GTPase-activating protein 32 isoform 1

      See identical proteins and their annotated locations for NP_001136157.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform is also known as PX-RICS.
      Source sequence(s)
      AL833062, AP000751, CK823137, EF127492
      Consensus CDS
      CCDS44769.1
      UniProtKB/Swiss-Prot
      A7KAX9
      UniProtKB/TrEMBL
      Q86T64
      Related
      ENSP00000310561.8, OTTHUMP00000230948, ENST00000310343.13, OTTHUMT00000386151
      Conserved Domains (3) summary
      cd07298
      Location:127241
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:263316
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:368562
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    2. NM_014715.3NP_055530.2  rho GTPase-activating protein 32 isoform 2

      See identical proteins and their annotated locations for NP_055530.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple exons in the 5' UTR and 5' coding region and has a unique exon for its 5' UTR, compared to variant 1. These differences cause translation initiation from a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus which lacks phox homology and src homology 3 domains, compared to isoform 1.
      Source sequence(s)
      AB079856, AP000751, BQ319051, EF127492
      Consensus CDS
      CCDS31718.1
      UniProtKB/Swiss-Prot
      A7KAX9
      Related
      ENSP00000376425.3, OTTHUMP00000230996, ENST00000392657.7, OTTHUMT00000386249
      Conserved Domains (1) summary
      cd04384
      Location:19213
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      128965060..129279168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018595.1XP_016874084.1  rho GTPase-activating protein 32 isoform X3

      Conserved Domains (3) summary
      cd07298
      Location:101215
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:237290
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:342536
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    2. XM_011543072.2XP_011541374.1  rho GTPase-activating protein 32 isoform X3

      See identical proteins and their annotated locations for XP_011541374.1

      Conserved Domains (3) summary
      cd07298
      Location:101215
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:237290
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:342536
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    3. XM_005271736.4XP_005271793.2  rho GTPase-activating protein 32 isoform X1

      Conserved Domains (3) summary
      cd07298
      Location:141255
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:277330
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:382576
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    4. XM_011543073.2XP_011541375.2  rho GTPase-activating protein 32 isoform X2

    5. XM_017018596.1XP_016874085.1  rho GTPase-activating protein 32 isoform X4

    6. XM_011543075.2XP_011541377.1  rho GTPase-activating protein 32 isoform X5

      Conserved Domains (1) summary
      cd04384
      Location:43237
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    7. XM_017018597.1XP_016874086.1  rho GTPase-activating protein 32 isoform X6

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      128721150..128948156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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