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    SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 [ Homo sapiens (human) ]

    Gene ID: 59343, updated on 20-Feb-2017
    Official Symbol
    SENP2provided by HGNC
    Official Full Name
    SUMO1/sentrin/SMT3 specific peptidase 2provided by HGNC
    Primary source
    HGNC:HGNC:23116
    See related
    Ensembl:ENSG00000163904 MIM:608261; Vega:OTTHUMG00000156658
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AXAM2; SMT3IP2
    Summary
    SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
    Orthologs
    Location:
    3q27.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (185586228..185631101)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185300284..185348889)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene lipase H Neighboring gene uncharacterized LOC107986055 Neighboring gene ribosomal protein L34 pseudogene 10 Neighboring gene insulin like growth factor 2 mRNA binding protein 2 Neighboring gene IGF2BP2 antisense RNA 1 Neighboring gene microRNA 548aq

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Nuclear pore complex, organism-specific biosystem (from KEGG)
      Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • Nuclear pore complex, conserved biosystem (from KEGG)
      Nuclear pore complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Processing and activation of SUMO, organism-specific biosystem (from REACTOME)
      Processing and activation of SUMO, organism-specific biosystemThe initial translation products of SUMO1, SUMO2, and SUMO3 are precursors that have extra amino acid residues at the C-terminus (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun ...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • SUMO is proteolytically processed, organism-specific biosystem (from REACTOME)
      SUMO is proteolytically processed, organism-specific biosystemSUMO1, 2, and 3 are initially expressed as propeptides containing extra residues at the C-terminus. (SUMO1 has 4 residues, SUMO2 has 2 residues, and SUMO3 has 11 residues,) SENP1, 2, and 5 are endopr...
    • SUMOylation, organism-specific biosystem (from REACTOME)
      SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA1331, DKFZp762A2316

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SUMO-specific endopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    SUMO-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    dorsal/ventral axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    labyrinthine layer development IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein desumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein desumoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein sumoylation TAS
    Traceable Author Statement
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of DNA endoreduplication IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    spongiotrophoblast layer development IEA
    Inferred from Electronic Annotation
    more info
     
    trophoblast giant cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    sentrin-specific protease 2
    Names
    SMT3-specific isopeptidase 2
    SUMO1/sentrin/SMT3 specific protease 2
    sentrin/SUMO-specific protease SENP2
    NP_067640.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021627.2NP_067640.2  sentrin-specific protease 2

      See identical proteins and their annotated locations for NP_067640.2

      Status: VALIDATED

      Source sequence(s)
      AF151697, AL834380, BC018020, BC040609
      Consensus CDS
      CCDS33902.1
      UniProtKB/Swiss-Prot
      Q9HC62
      Related
      ENSP00000296257, OTTHUMP00000210348, ENST00000296257, OTTHUMT00000345159
      Conserved Domains (1) summary
      cl23802
      Location:336584
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      185586228..185631101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247690.2XP_005247747.2  sentrin-specific protease 2 isoform X1

      Conserved Domains (1) summary
      cl23802
      Location:370540
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    2. XM_005247691.2XP_005247748.1  sentrin-specific protease 2 isoform X2

      Conserved Domains (1) summary
      cl23802
      Location:221469
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    3. XM_017006973.1XP_016862462.1  sentrin-specific protease 2 isoform X3

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      185267116..185311866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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