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    SDHA succinate dehydrogenase complex flavoprotein subunit A [ Homo sapiens (human) ]

    Gene ID: 6389, updated on 23-Jul-2017
    Official Symbol
    SDHAprovided by HGNC
    Official Full Name
    succinate dehydrogenase complex flavoprotein subunit Aprovided by HGNC
    Primary source
    HGNC:HGNC:10680
    See related
    Ensembl:ENSG00000073578 MIM:600857; Vega:OTTHUMG00000090275
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FP; PGL5; SDH1; SDH2; SDHF; CMD1GG
    Summary
    This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
    Orthologs
    Location:
    5p15.33
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (218223..264816)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (218338..256815)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 14B Neighboring gene coiled-coil domain containing 127 Neighboring gene heart tissue-associated transcript 5 Neighboring gene programmed cell death 6 Neighboring gene protein phosphatase 4 regulatory subunit 2 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef is identified to have a physical interaction with succinate dehydrogenase complex, subunit A, flavoprotein (SDHA) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of succinate dehydrogenase complex, subunit A (SDHA) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    electron carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    succinate dehydrogenase (ubiquinone) activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to succinate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    anaerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrial electron transport, succinate to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    respiratory electron transport chain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    succinate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    NOT plasma membrane succinate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
    Names
    flavoprotein subunit of complex II
    succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
    NP_001281261.1
    NP_004159.2
    XP_005248388.1
    XP_011512374.1
    XP_011512375.1
    XP_016865174.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012339.1 RefSeqGene

      Range
      4983..43842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001294332.1NP_001281261.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC021087, AK291311, AK295937, DA160919, HY265959
      Consensus CDS
      CCDS77992.1
      UniProtKB/Swiss-Prot
      P31040
      Related
      ENSP00000427703.1, OTTHUMP00000221434, ENST00000510361.5, OTTHUMT00000367626
      Conserved Domains (3) summary
      PTZ00139
      Location:40616
      PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
      pfam02910
      Location:467616
      Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
      cl21454
      Location:104423
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_001330758.1NP_001317687.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC021087
      Consensus CDS
      CCDS82985.1
      UniProtKB/TrEMBL
      D6RFM5
      Conserved Domains (3) summary
      PTZ00139
      Location:40583
      PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
      pfam02910
      Location:539583
      Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
      cl21454
      Location:85471
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. NM_004168.3NP_004159.2  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_004159.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC021087, AK291311, BC001380, DA160919, HY265959
      Consensus CDS
      CCDS3853.1
      UniProtKB/Swiss-Prot
      P31040
      UniProtKB/TrEMBL
      A0A024QZ30
      Related
      ENSP00000264932.6, OTTHUMP00000115308, ENST00000264932.10, OTTHUMT00000206599
      Conserved Domains (3) summary
      PTZ00139
      Location:40664
      PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
      pfam02910
      Location:515664
      Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
      cl21454
      Location:85471
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      218223..264816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514072.1XP_011512374.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X2

      Conserved Domains (3) summary
      PTZ00139
      Location:40636
      PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
      pfam02910
      Location:515635
      Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
      cl21454
      Location:85471
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_011514073.1XP_011512375.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X3

      Conserved Domains (2) summary
      TIGR01816
      Location:80555
      sdhA_forward; succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup
      cl21454
      Location:85471
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. XM_017009685.1XP_016865174.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1

    4. XM_005248331.3XP_005248388.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X4

      Related
      ENSP00000426514.1, OTTHUMP00000221433, ENST00000504309.5, OTTHUMT00000367624
      Conserved Domains (3) summary
      PTZ00139
      Location:40583
      PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
      pfam02910
      Location:539583
      Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
      cl21454
      Location:85471
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      215713..254568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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