Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    TNFRSF21 TNF receptor superfamily member 21 [ Homo sapiens (human) ]

    Gene ID: 27242, updated on 5-Nov-2017
    Official Symbol
    TNFRSF21provided by HGNC
    Official Full Name
    TNF receptor superfamily member 21provided by HGNC
    Primary source
    HGNC:HGNC:13469
    See related
    Ensembl:ENSG00000146072 MIM:605732; Vega:OTTHUMG00000014796
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DR6; CD358; BM-018
    Summary
    This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
    Orthologs
    Location:
    6p12.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (47231527..47309976, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (47199263..47277683, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F1 Neighboring gene uncharacterized LOC105375081 Neighboring gene uncharacterized LOC105375082 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 pseudogene 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of panic disorder in the Japanese population.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of TNFRSF21 PubMed

    Go to the HIV-1, Human Interaction Database

    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystem (from WikiPathways)
      Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystemResults of pathway analysis of apoptosis-related genes in OVCAR3 cells treated with Notch3 siRNA or control siRNA.
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
      PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC31965

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    tumor necrosis factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    B cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    humoral immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interleukin-10 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interleukin-13 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interleukin-5 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oligodendrocyte apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of lipid metabolic process TAS
    Traceable Author Statement
    more info
     
    regulation of oligodendrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of oligodendrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    tumor necrosis factor receptor superfamily member 21
    Names
    TNFR-related death receptor 6
    death receptor 6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014452.4NP_055267.1  tumor necrosis factor receptor superfamily member 21 precursor

      See identical proteins and their annotated locations for NP_055267.1

      Status: REVIEWED

      Source sequence(s)
      AY358304, DR761236, HY007775
      Consensus CDS
      CCDS4921.1
      UniProtKB/Swiss-Prot
      O75509
      UniProtKB/TrEMBL
      A0A024RD71
      Related
      ENSP00000296861.2, OTTHUMP00000016561, ENST00000296861.2, OTTHUMT00000040814
      Conserved Domains (3) summary
      cd08778
      Location:414497
      Death_TNFRSF21; Death domain of tumor necrosis factor receptor superfamily member 21
      cd10583
      Location:53211
      TNFRSF21; Tumor necrosis factor receptor superfamily member 21 (TNFRSF21), also known as death receptor (DR6)
      cl14633
      Location:594654
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      47231527..47309976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010744.1XP_016866233.1  tumor necrosis factor receptor superfamily member 21 isoform X1

      Conserved Domains (1) summary
      cd10583
      Location:53211
      TNFRSF21; Tumor necrosis factor receptor superfamily member 21 (TNFRSF21), also known as death receptor (DR6)

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      47202168..47280589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center