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    DNTTIP1 deoxynucleotidyltransferase terminal interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 116092, updated on 3-Sep-2017
    Official Symbol
    DNTTIP1provided by HGNC
    Official Full Name
    deoxynucleotidyltransferase terminal interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:16160
    See related
    Ensembl:ENSG00000101457 MIM:611388; Vega:OTTHUMG00000032610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Tdif1; C20orf167; dJ447F3.4
    Summary
    DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).[supplied by OMIM, Mar 2008]
    Orthologs
    Location:
    20q13.12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (45791937..45811427)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44420576..44440066)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 3 Neighboring gene serine peptidase inhibitor, Kunitz type 5, pseudogene Neighboring gene RNA, U6atac small nuclear 38, pseudogene Neighboring gene ubiquitin conjugating enzyme E2 C Neighboring gene troponin C2, fast skeletal type

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    deoxynucleotidyltransferase terminal-interacting protein 1
    Names
    TdT binding protein
    tdT-interacting factor 1
    terminal deoxynucleotidyltransferase-interacting factor 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052951.2NP_443183.1  deoxynucleotidyltransferase terminal-interacting protein 1

      See identical proteins and their annotated locations for NP_443183.1

      Status: VALIDATED

      Source sequence(s)
      AB035676, AI538721, BG720866, CD678110
      Consensus CDS
      CCDS13369.1
      UniProtKB/Swiss-Prot
      Q9H147
      Related
      ENSP00000361705.3, OTTHUMP00000031161, ENST00000372622.7, OTTHUMT00000079502

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      45791937..45811427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      44323274..44343207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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