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    DCBLD2 discoidin, CUB and LCCL domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 131566, updated on 9-Jul-2017
    Official Symbol
    DCBLD2provided by HGNC
    Official Full Name
    discoidin, CUB and LCCL domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:24627
    See related
    Ensembl:ENSG00000057019 MIM:608698; Vega:OTTHUMG00000151985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESDN; CLCP1
    Orthologs
    Location:
    3q12.1; 3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (98795970..98901689, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (98514814..98620566, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ST3GAL6 antisense RNA 1 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 6 Neighboring gene PDZ and LIM domain 1 pseudogene 4 Neighboring gene RNA, U6 small nuclear 26, pseudogene Neighboring gene uncharacterized LOC105374002 Neighboring gene RNA, U6 small nuclear 1263, pseudogene Neighboring gene uncharacterized LOC105374003

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    intracellular receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    discoidin, CUB and LCCL domain-containing protein 2
    Names
    1700055P21Rik
    CUB, LCCL and coagulation factor V/VIII-homology domains protein 1
    coagulation factor V/VIII-homology domains protein 1
    endothelial and smooth muscle cell-derived neuropilin-like protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080927.3NP_563615.3  discoidin, CUB and LCCL domain-containing protein 2 precursor

      See identical proteins and their annotated locations for NP_563615.3

      Status: VALIDATED

      Source sequence(s)
      AB073146, AF387547
      Consensus CDS
      CCDS46878.1
      UniProtKB/Swiss-Prot
      Q96PD2
      Related
      ENSP00000321573.6, OTTHUMP00000200890, ENST00000326840.10, OTTHUMT00000324675
      Conserved Domains (4) summary
      smart00603
      Location:193276
      LCCL; LCCL domain
      smart00231
      Location:291449
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:72186
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:296448
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      98795970..98901689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512419.2XP_011510721.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X1

      Conserved Domains (4) summary
      smart00603
      Location:117200
      LCCL; LCCL domain
      smart00231
      Location:215373
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:220372
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl00049
      Location:69110
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      98477944..98585228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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