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    USP10 ubiquitin specific peptidase 10 [ Homo sapiens (human) ]

    Gene ID: 9100, updated on 12-Mar-2017
    Official Symbol
    USP10provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 10provided by HGNC
    Primary source
    HGNC:HGNC:12608
    See related
    Ensembl:ENSG00000103194 MIM:609818; Vega:OTTHUMG00000176770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBPO
    Summary
    Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
    Orthologs
    Location:
    16q24.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (84699949..84779922)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (84733555..84813528)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene coactosin like F-actin binding protein 1 Neighboring gene uncharacterized LOC105371376 Neighboring gene kelch like family member 36 Neighboring gene uncharacterized LOC105371378 Neighboring gene cysteine rich secretory protein LCCL domain containing 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
    NHGRI GWA Catalog
    Many sequence variants affecting diversity of adult human height.
    NHGRI GWA Catalog
    • DNA Damage Bypass, organism-specific biosystem (from REACTOME)
      DNA Damage Bypass, organism-specific biosystemIn addition to various processes for removing lesions from the DNA, cells have developed specific mechanisms for tolerating unrepaired damage during the replication of the genome. These mechanisms ar...
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Termination of translesion DNA synthesis, organism-specific biosystem (from REACTOME)
      Termination of translesion DNA synthesis, organism-specific biosystemThe initiation and extent of translesion DNA synthesis (TLS) has to be tightly controlled in order to limit TLS-induced mutagenesis, caused by the low fidelity of TLS-participating DNA polymerases. S...
    • Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, organism-specific biosystem (from REACTOME)
      Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, organism-specific biosystemUbiquitous environmental and endogenous genotoxic agents cause DNA lesions that can interfere with normal DNA metabolism including DNA replication, eventually resulting in mutations that lead to carc...
    • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
      Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC2621, KIAA0190

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion channel binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity TAS
    Traceable Author Statement
    more info
     
    thiol-dependent ubiquitinyl hydrolase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to interleukin-1 IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    translesion synthesis TAS
    Traceable Author Statement
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 10
    Names
    deubiquitinating enzyme 10
    ubiquitin specific protease 10
    ubiquitin thioesterase 10
    ubiquitin thiolesterase 10
    ubiquitin-specific-processing protease 10
    NP_001259004.1
    NP_005144.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272075.1NP_001259004.1  ubiquitin carboxyl-terminal hydrolase 10 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK299618, D80012, DB077919, GD151792
      Consensus CDS
      CCDS62004.1
      UniProtKB/Swiss-Prot
      Q14694
      Related
      ENSP00000457411, OTTHUMP00000255062, ENST00000570191, OTTHUMT00000433668
      Conserved Domains (2) summary
      cd02257
      Location:524797
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:418796
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. NM_005153.2NP_005144.2  ubiquitin carboxyl-terminal hydrolase 10 isoform 2

      See identical proteins and their annotated locations for NP_005144.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC009116, BC000263, BX537402, DB077919
      Consensus CDS
      CCDS45537.1
      UniProtKB/Swiss-Prot
      Q14694
      Related
      ENSP00000219473, OTTHUMP00000255058, ENST00000219473, OTTHUMT00000433660
      Conserved Domains (2) summary
      cd02257
      Location:520793
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:414792
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RNA

    1. NR_073577.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK293304, D80012, DB077919, GD151792
    2. NR_073578.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks four alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of two upstream ORFs that are predicted to interfere with translation of the longest ORF; translation of either of the upstream ORFs renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CR749515, D80012, DB077919, GD151792
      Related
      ENST00000540269, OTTHUMT00000433665

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      84699949..84779922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023869.1XP_016879358.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      Conserved Domains (2) summary
      cd02257
      Location:324597
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:218596
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. XM_017023864.1XP_016879353.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      Conserved Domains (2) summary
      cd02257
      Location:324597
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:218596
      UCH; Ubiquitin carboxyl-terminal hydrolase
    3. XM_011523441.1XP_011521743.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      See identical proteins and their annotated locations for XP_011521743.1

      Conserved Domains (2) summary
      cd02257
      Location:324597
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:218596
      UCH; Ubiquitin carboxyl-terminal hydrolase
    4. XM_011523440.1XP_011521742.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      See identical proteins and their annotated locations for XP_011521742.1

      Conserved Domains (2) summary
      cd02257
      Location:324597
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:218596
      UCH; Ubiquitin carboxyl-terminal hydrolase
    5. XM_017023868.1XP_016879357.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      Conserved Domains (2) summary
      cd02257
      Location:324597
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:218596
      UCH; Ubiquitin carboxyl-terminal hydrolase
    6. XM_011523443.1XP_011521745.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      See identical proteins and their annotated locations for XP_011521745.1

      Conserved Domains (2) summary
      cd02257
      Location:324597
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:218596
      UCH; Ubiquitin carboxyl-terminal hydrolase
    7. XM_017023863.1XP_016879352.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      Conserved Domains (2) summary
      cd02257
      Location:324597
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:218596
      UCH; Ubiquitin carboxyl-terminal hydrolase
    8. XM_006721332.1XP_006721395.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      See identical proteins and their annotated locations for XP_006721395.1

      Conserved Domains (2) summary
      cd02257
      Location:324597
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:218596
      UCH; Ubiquitin carboxyl-terminal hydrolase
    9. XM_017023867.1XP_016879356.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      Conserved Domains (2) summary
      cd02257
      Location:324597
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:218596
      UCH; Ubiquitin carboxyl-terminal hydrolase
    10. XM_017023865.1XP_016879354.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      Conserved Domains (2) summary
      cd02257
      Location:324597
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:218596
      UCH; Ubiquitin carboxyl-terminal hydrolase
    11. XM_017023866.1XP_016879355.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      Conserved Domains (2) summary
      cd02257
      Location:324597
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:218596
      UCH; Ubiquitin carboxyl-terminal hydrolase

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      86145099..86225097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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