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    PTPRT protein tyrosine phosphatase, receptor type T [ Homo sapiens (human) ]

    Gene ID: 11122, updated on 5-Nov-2017
    Official Symbol
    PTPRTprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase, receptor type Tprovided by HGNC
    Primary source
    HGNC:HGNC:9682
    See related
    Ensembl:ENSG00000196090 MIM:608712; Vega:OTTHUMG00000033040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPTPrho
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 9.9) and placenta (RPKM 1.1) See more
    Orthologs
    Location:
    20q12-q13.11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (42072752..43189917, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (40701392..41818557, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927182 Neighboring gene uncharacterized LOC105372622 Neighboring gene neurofilament heavy polypeptide pseudogene Neighboring gene uncharacterized LOC105372624 Neighboring gene uncharacterized LOC101927159 Neighboring gene uncharacterized LOC105372623 Neighboring gene uncharacterized LOC101927138 Neighboring gene RNA, 7SK small nuclear pseudogene 100 Neighboring gene RNA, 7SL, cytoplasmic 666, pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene 21

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
    NHGRI GWA Catalog
    Genome-wide association study of chronic periodontitis in a general German population.
    NHGRI GWA Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0283

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    alpha-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cadherin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    delta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    gamma-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    receptor-type tyrosine-protein phosphatase T
    Names
    R-PTP-T
    RPTP-rho
    receptor protein tyrosine phosphatase
    receptor-type tyrosine-protein phosphatase rho
    NP_008981.4
    NP_573400.3
    XP_016883100.1
    XP_016883101.1
    XP_016883102.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033880.1 RefSeqGene

      Range
      5001..1122166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007050.5NP_008981.4  receptor-type tyrosine-protein phosphatase T isoform 2 precursor

      See identical proteins and their annotated locations for NP_008981.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a fragment within the coding region when compared to variant 1. The translation remains in-frame, and thus encodes a protein that lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AB006621, AF043644, AL021395, AL707728, DA791336, R50970
      Consensus CDS
      CCDS42874.1
      UniProtKB/Swiss-Prot
      O14522
      Related
      ENSP00000362283.1, OTTHUMP00000031658, ENST00000373187.5, OTTHUMT00000080315
      Conserved Domains (7) summary
      cd06263
      Location:32189
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:29189
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:8881142
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:9151142
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:502584
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:294360
      fn3; Fibronectin type III domain
      cl11960
      Location:196281
      Ig; Immunoglobulin domain
    2. NM_133170.3NP_573400.3  receptor-type tyrosine-protein phosphatase T isoform 1 precursor

      See identical proteins and their annotated locations for NP_573400.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB006621, AF043644, AL021395, AL707728, DA791336, R50970
      Consensus CDS
      CCDS68127.1
      UniProtKB/Swiss-Prot
      O14522
      UniProtKB/TrEMBL
      A0A075B6H0
      Related
      ENSP00000362294.4, OTTHUMP00000031661, ENST00000373198.8, OTTHUMT00000080318
      Conserved Domains (7) summary
      cd06263
      Location:32189
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:29189
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:9071161
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:9341161
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:502584
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:294360
      fn3; Fibronectin type III domain
      cl11960
      Location:196281
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      42072752..43189917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027611.1XP_016883100.1  receptor-type tyrosine-protein phosphatase T isoform X1

      Related
      ENSP00000362280.1, OTTHUMP00000031662, ENST00000373184.5, OTTHUMT00000080319
    2. XM_017027612.1XP_016883101.1  receptor-type tyrosine-protein phosphatase T isoform X2

    3. XM_017027613.1XP_016883102.1  receptor-type tyrosine-protein phosphatase T isoform X3

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      40605787..41722632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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