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    LENEP lens epithelial protein [ Homo sapiens (human) ]

    Gene ID: 55891, updated on 25-May-2017
    Official Symbol
    LENEPprovided by HGNC
    Official Full Name
    lens epithelial proteinprovided by HGNC
    Primary source
    HGNC:HGNC:14429
    See related
    Ensembl:ENSG00000163352 MIM:607377; Vega:OTTHUMG00000037417
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LEP503
    Summary
    The ocular lens is a tissue of epithelial origin and devoid of blood vessels and nerves. Cells of the lens epithelium are responsible for the growth and maintenance of the lens through mitosis, protein synthesis, and active transport of ions and metabolites across the lens capsule. Lens epithelial protein is expressed exclusively in lens epithelial cells and may play a role in cell differentiation. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1q21.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (154993586..154994315)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154966062..154966791)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 4258 Neighboring gene CDC28 protein kinase regulatory subunit 1B Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene DC-STAMP domain containing 2 Neighboring gene DC-STAMP domain containing 1 Neighboring gene DCST1 antisense RNA 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    NHGRI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    NHGRI GWA Catalog

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    lens epithelial cell protein LEP503

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018655.2NP_061125.1  lens epithelial cell protein LEP503

      See identical proteins and their annotated locations for NP_061125.1

      Status: REVIEWED

      Source sequence(s)
      AF268478, BC069140, BM716801
      Consensus CDS
      CCDS1080.1
      UniProtKB/Swiss-Prot
      Q9Y5L5
      Related
      ENSP00000357412.3, OTTHUMP00000035554, ENST00000368427.3, OTTHUMT00000091101
      Conserved Domains (1) summary
      pfam15221
      Location:161
      LEP503; Lens epithelial cell protein LEP503

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      154993586..154994315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      156362464..156363193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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