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    NEUROG1 neurogenin 1 [ Homo sapiens (human) ]

    Gene ID: 4762, updated on 6-Aug-2017
    Official Symbol
    NEUROG1provided by HGNC
    Official Full Name
    neurogenin 1provided by HGNC
    Primary source
    HGNC:HGNC:7764
    See related
    Ensembl:ENSG00000181965 MIM:601726; Vega:OTTHUMG00000129138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AKA; ngn1; Math4C; bHLHa6; NEUROD3
    Orthologs
    Location:
    5q31.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (135534282..135535949, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134869972..134871639, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene dendritic cell associated nuclear protein Neighboring gene TIFA inhibitor Neighboring gene solute carrier family 25 member 48 Neighboring gene C-X-C motif chemokine ligand 14 Neighboring gene long intergenic non-protein coding RNA 1959

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    E-box binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    E-box binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor activity, transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    auditory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    cochlea development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cochlea morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    craniofacial suture morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    genitalia development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    genitalia morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hard palate morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    learned vocalization behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mastication IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of relaxation of muscle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of saliva secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    palate development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peristalsis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of exit from mitosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of muscle organ development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    thorax and anterior abdomen determination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    trigeminal nerve development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vestibulocochlear nerve formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    neurogenin-1
    Names
    NGN-1
    class A basic helix-loop-helix protein 6
    neurogenic basic-helix-loop-helix protein
    neurogenic differentiation 3
    neurogenic differentiation factor 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006161.2NP_006152.2  neurogenin-1

      See identical proteins and their annotated locations for NP_006152.2

      Status: VALIDATED

      Source sequence(s)
      BC028226
      Consensus CDS
      CCDS4187.1
      UniProtKB/Swiss-Prot
      Q92886
      UniProtKB/TrEMBL
      F1T0H3
      Related
      ENSP00000317580.4, OTTHUMP00000159409, ENST00000314744.5, OTTHUMT00000251192
      Conserved Domains (2) summary
      cd00083
      Location:90149
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01499
      Location:87229
      Herpes_UL25; Herpesvirus UL25 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      135534282..135535949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      134302579..134304246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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