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    ZFAND6 zinc finger AN1-type containing 6 [ Homo sapiens (human) ]

    Gene ID: 54469, updated on 4-Jun-2017
    Official Symbol
    ZFAND6provided by HGNC
    Official Full Name
    zinc finger AN1-type containing 6provided by HGNC
    Primary source
    HGNC:HGNC:30164
    See related
    Ensembl:ENSG00000086666 MIM:610183; Vega:OTTHUMG00000144169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AWP1; ZA20D3; ZFAND5B
    Orthologs
    Location:
    15q25.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (80059568..80138393)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (80351910..80430735)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ribonucleotide reductase regulatory subunit M2 pseudogene Neighboring gene BCL2 related protein A1 Neighboring gene fumarylacetoacetate hydrolase Neighboring gene long intergenic non-protein coding RNA 1314

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    polyubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein targeting to peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    AN1-type zinc finger protein 6
    Names
    protein associated with PRK1
    zinc finger, A20 domain containing 3
    zinc finger, AN1-type domain 6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242911.1NP_001229840.1  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_001229840.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
      Source sequence(s)
      AC092701, AL136598, AW571396, DB050060
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      Q6FIF0
      Related
      ENSP00000454137.1, OTTHUMP00000247605, ENST00000558494.5, OTTHUMT00000416734
      Conserved Domains (3) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
      pfam06484
      Location:25142
      Ten_N; Teneurin Intracellular Region
    2. NM_001242912.1NP_001229841.1  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_001229841.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
      Source sequence(s)
      AC092701, AW571396, BX363429, DB050060
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      Q6FIF0
      Related
      ENSP00000479071.1, ENST00000613266.4
      Conserved Domains (3) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
      pfam06484
      Location:25142
      Ten_N; Teneurin Intracellular Region
    3. NM_001242913.1NP_001229842.1  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_001229842.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
      Source sequence(s)
      AC092701, AW571396, CN428457
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      Q6FIF0
      Related
      ENSP00000478129.1, ENST00000616533.4
      Conserved Domains (3) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
      pfam06484
      Location:25142
      Ten_N; Teneurin Intracellular Region
    4. NM_001242914.1NP_001229843.1  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_001229843.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
      Source sequence(s)
      AC092701, AW571396, BG720174, BI562073
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      Q6FIF0
      Related
      ENSP00000484971.1, ENST00000618205.4
      Conserved Domains (3) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
      pfam06484
      Location:25142
      Ten_N; Teneurin Intracellular Region
    5. NM_001242915.1NP_001229844.1  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_001229844.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
      Source sequence(s)
      AF261138, AW571396, DA091136
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      Q6FIF0
      Related
      ENSP00000453291.1, OTTHUMP00000247606, ENST00000559835.5, OTTHUMT00000416738
      Conserved Domains (3) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
      pfam06484
      Location:25142
      Ten_N; Teneurin Intracellular Region
    6. NM_001242916.1NP_001229845.1  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_001229845.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
      Source sequence(s)
      AC092701, AW571396, DA091136, DR762914
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      Q6FIF0
      Related
      ENSP00000453709.1, OTTHUMP00000247607, ENST00000559775.5, OTTHUMT00000416739
      Conserved Domains (3) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
      pfam06484
      Location:25142
      Ten_N; Teneurin Intracellular Region
    7. NM_001242917.1NP_001229846.1  AN1-type zinc finger protein 6 isoform b

      See identical proteins and their annotated locations for NP_001229846.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC092701, AF061739, AW571396, DB050060
      Consensus CDS
      CCDS58395.1
      UniProtKB/Swiss-Prot
      Q6FIF0
      Related
      ENSP00000454152.1, OTTHUMP00000247603, ENST00000559157.5, OTTHUMT00000416732
      Conserved Domains (3) summary
      smart00154
      Location:137174
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
      pfam06484
      Location:25130
      Ten_N; Teneurin Intracellular Region
    8. NM_001242918.1NP_001229847.1  AN1-type zinc finger protein 6 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC092701, AW571396, BP231220, DB050060
      Related
      ENSP00000454273.1, OTTHUMP00000254868, ENST00000564367.5, OTTHUMT00000433315
      Conserved Domains (3) summary
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
      pfam06484
      Location:25117
      Ten_N; Teneurin Intracellular Region
      cl01438
      Location:118148
      zf-AN1; AN1-like Zinc finger
    9. NM_001242919.1NP_001229848.1  AN1-type zinc finger protein 6 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC092701, AW571396, BP234517
      Conserved Domains (2) summary
      smart00154
      Location:122159
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
    10. NM_019006.3NP_061879.2  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_061879.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-7 all encode isoform a.
      Source sequence(s)
      AW571396, BC005283, DB050060
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      Q6FIF0
      Related
      ENSP00000261749.6, OTTHUMP00000185562, ENST00000261749.10, OTTHUMT00000291368
      Conserved Domains (3) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
      pfam06484
      Location:25142
      Ten_N; Teneurin Intracellular Region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      80059568..80138393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521684.2XP_011519986.1  AN1-type zinc finger protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011519986.1

      UniProtKB/Swiss-Prot
      Q6FIF0
      Conserved Domains (3) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
      pfam06484
      Location:25142
      Ten_N; Teneurin Intracellular Region

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      80469860..80548702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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