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    TCL1A T cell leukemia/lymphoma 1A [ Homo sapiens (human) ]

    Gene ID: 8115, updated on 8-Apr-2018
    Official Symbol
    TCL1Aprovided by HGNC
    Official Full Name
    T cell leukemia/lymphoma 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:11648
    See related
    Ensembl:ENSG00000100721 MIM:186960; Vega:OTTHUMG00000171390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCL1
    Summary
    Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
    Expression
    Biased expression in lymph node (RPKM 72.1), spleen (RPKM 19.8) and 2 other tissues See more
    Orthologs
    Location:
    14q32.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (95694160..95714196, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96176304..96180533, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene T cell leukemia/lymphoma 6 (non-protein coding) Neighboring gene T cell leukemia/lymphoma 1B Neighboring gene uncharacterized LOC107984703 Neighboring gene uncharacterized LOC105370644

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors.
    NHGRI GWA Catalog
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Preferred Names
    T-cell leukemia/lymphoma protein 1A
    Names
    T-cell lymphoma-1
    oncogene TCL-1
    oncogene TCL1
    protein p14 TCL1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098725.1NP_001092195.1  T-cell leukemia/lymphoma protein 1A

      See identical proteins and their annotated locations for NP_001092195.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL139020, BC014024, BG718395, X82240
      Consensus CDS
      CCDS9941.1
      UniProtKB/Swiss-Prot
      P56279
      UniProtKB/TrEMBL
      A0A024R6G5
      Related
      ENSP00000451506.1, OTTHUMP00000245945, ENST00000554012.5, OTTHUMT00000413245
      Conserved Domains (1) summary
      pfam01840
      Location:1112
      TCL1_MTCP1; TCL1/MTCP1 family
    2. NM_021966.2NP_068801.1  T-cell leukemia/lymphoma protein 1A

      See identical proteins and their annotated locations for NP_068801.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AL139020, BC014024, BG718395, X82240
      Consensus CDS
      CCDS9941.1
      UniProtKB/Swiss-Prot
      P56279
      UniProtKB/TrEMBL
      A0A024R6G5
      Related
      ENSP00000385036.1, ENST00000402399.5
      Conserved Domains (1) summary
      pfam01840
      Location:1112
      TCL1_MTCP1; TCL1/MTCP1 family

    RNA

    1. NR_049726.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL139020, BG718395, BU602054, X82240

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      95694160..95714196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021676.2XP_016877165.1  T-cell leukemia/lymphoma protein 1A isoform X1

      UniProtKB/Swiss-Prot
      P56279
      UniProtKB/TrEMBL
      A0A024R6G5
      Conserved Domains (1) summary
      pfam01840
      Location:1112
      TCL1_MTCP1; TCL1/MTCP1 family
    2. XM_017021677.2XP_016877166.1  T-cell leukemia/lymphoma protein 1A isoform X1

      UniProtKB/Swiss-Prot
      P56279
      UniProtKB/TrEMBL
      A0A024R6G5
      Related
      ENSP00000450496.1, OTTHUMP00000245951, ENST00000555202.1
      Conserved Domains (1) summary
      pfam01840
      Location:1112
      TCL1_MTCP1; TCL1/MTCP1 family
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