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    DBH dopamine beta-hydroxylase [ Homo sapiens (human) ]

    Gene ID: 1621, updated on 25-Sep-2016
    Official Symbol
    DBHprovided by HGNC
    Official Full Name
    dopamine beta-hydroxylaseprovided by HGNC
    Primary source
    HGNC:HGNC:2689
    See related
    Ensembl:ENSG00000123454 HPRD:01963; MIM:609312; Vega:OTTHUMG00000020878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DBM
    Summary
    The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    9q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (133636363..133659344)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136501485..136524466)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ADAMTS like 2 Neighboring gene family with sequence similarity 163 member B Neighboring gene uncharacterized LOC105376308 Neighboring gene DBH antisense RNA 1 Neighboring gene sarcosine dehydrogenase Neighboring gene vav guanine nucleotide exchange factor 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity TAS
    Traceable Author Statement
    more info
    PubMed 
    copper ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dopamine beta-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dopamine beta-monooxygenase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    behavioral response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    catecholamine biosynthetic process TAS
    Traceable Author Statement
    more info
     
    chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    dopamine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fear response IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    homoiothermy IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte mediated immunity IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    maternal behavior IEA
    Inferred from Electronic Annotation
    more info
     
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    norepinephrine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    norepinephrine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    octopamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromaffin granule lumen IEA
    Inferred from Electronic Annotation
    more info
     
    chromaffin granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    secretory granule lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    secretory granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    dopamine beta-hydroxylase
    Names
    dopamine beta-hydroxylase (dopamine beta-monooxygenase)
    NP_000778.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008645.1 RefSeqGene

      Range
      5001..27982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000787.3NP_000778.3  dopamine beta-hydroxylase precursor

      See identical proteins and their annotated locations for NP_000778.3

      Status: REVIEWED

      Source sequence(s)
      AL365494, BC017174, CD014125, X13255
      Consensus CDS
      CCDS6977.2
      UniProtKB/Swiss-Prot
      P09172
      Related
      ENSP00000376776, OTTHUMP00000022501, ENST00000393056, OTTHUMT00000054929
      Conserved Domains (3) summary
      pfam01082
      Location:213337
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03351
      Location:57172
      DOMON; DOMON domain
      pfam03712
      Location:362516
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      133636363..133659344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      136651448..136674425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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