Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    FLVCR1 feline leukemia virus subgroup C cellular receptor 1 [ Homo sapiens (human) ]

    Gene ID: 28982, updated on 6-Aug-2017
    Official Symbol
    FLVCR1provided by HGNC
    Official Full Name
    feline leukemia virus subgroup C cellular receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:24682
    See related
    Ensembl:ENSG00000162769 MIM:609144; Vega:OTTHUMG00000036924
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCA; AXPC1; FLVCR; PCARP; MFSD7B
    Summary
    This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011]
    Orthologs
    Location:
    1q32.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (212858255..212899363)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (213031597..213072705)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene FLVCR1 antisense RNA 1 (head to head) Neighboring gene ribosomal protein S28 pseudogene 2 Neighboring gene vasohibin 2 Neighboring gene angel homolog 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ33420

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    heme transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heme transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heme transporter activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    cellular iron ion homeostasis TAS
    Traceable Author Statement
    more info
     
    embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    erythrocyte maturation IEA
    Inferred from Electronic Annotation
    more info
     
    head morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    heme export IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heme transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multicellular organism development TAS
    Traceable Author Statement
    more info
    PubMed 
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    feline leukemia virus subgroup C receptor-related protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028131.1 RefSeqGene

      Range
      5001..46109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014053.3NP_054772.1  feline leukemia virus subgroup C receptor-related protein 1

      See identical proteins and their annotated locations for NP_054772.1

      Status: REVIEWED

      Source sequence(s)
      AC104333, AF118637, AK090739, AK314481, GD138340
      Consensus CDS
      CCDS1510.1
      UniProtKB/Swiss-Prot
      Q9Y5Y0
      UniProtKB/TrEMBL
      B2RB38
      Related
      ENSP00000355938.4, OTTHUMP00000035011, ENST00000366971.8, OTTHUMT00000089678
      Conserved Domains (2) summary
      cd06174
      Location:111512
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:113478
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      212858255..212899363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509446.2XP_011507748.1  feline leukemia virus subgroup C receptor-related protein 1 isoform X1

      Conserved Domains (2) summary
      cd06174
      Location:111475
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:113406
      MFS_1; Major Facilitator Superfamily
    2. XM_011509447.2XP_011507749.1  feline leukemia virus subgroup C receptor-related protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011507749.1

      Conserved Domains (2) summary
      cd06174
      Location:111294
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:113294
      MFS_1; Major Facilitator Superfamily
    3. XM_011509448.1XP_011507750.1  feline leukemia virus subgroup C receptor-related protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011507750.1

      Conserved Domains (2) summary
      cd06174
      Location:111294
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:113294
      MFS_1; Major Facilitator Superfamily

    RNA

    1. XR_247024.2 RNA Sequence

    2. XR_426771.1 RNA Sequence

    3. XR_426772.3 RNA Sequence

    4. XR_921769.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      214303965..214345035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center