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    PICK1 protein interacting with PRKCA 1 [ Homo sapiens (human) ]

    Gene ID: 9463, updated on 12-Mar-2017
    Official Symbol
    PICK1provided by HGNC
    Official Full Name
    protein interacting with PRKCA 1provided by HGNC
    Primary source
    HGNC:HGNC:9394
    See related
    Ensembl:ENSG00000100151 MIM:605926; Vega:OTTHUMG00000151159
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PICK; PRKCABP
    Summary
    The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    22q13.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 22 NC_000022.11 (38056311..38075704)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38453262..38471708)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit F Neighboring gene SRY-box 10 Neighboring gene microRNA 4534 Neighboring gene uncharacterized LOC105373027 Neighboring gene solute carrier family 16 member 8 Neighboring gene BAI1 associated protein 2 like 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
      Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemExcitatory synaptic transmission in the brain is carried out by glutamate receptors through the activation of both ionotropic and metabotropic receptors. Ionotropic glutamate receptors are of three ...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
      Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
    • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
      Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
    • Trafficking of GluR2-containing AMPA receptors, organism-specific biosystem (from REACTOME)
      Trafficking of GluR2-containing AMPA receptors, organism-specific biosystemTrafficking of GluR2-containing receptors is governed by protein protein interactions that are regulated by phosphorylation events. GluR2 binds NSF and AP2 in the proximal C terminal region and binds...
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC15204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Arp2/3 complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    G-protein coupled receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase C binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    DNA methylation involved in embryo development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    DNA methylation involved in gamete generation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to decreased oxygen levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to glucose starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glial cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long term synaptic depression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    monoamine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of Arp2/3 complex-mediated actin nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal ion channel clustering TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    retrograde vesicle-mediated transport, Golgi to ER NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aggresome IDA
    Inferred from Direct Assay
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    PRKCA-binding protein
    Names
    protein interacting with C kinase 1
    protein kinase C-alpha-binding protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039583.1NP_001034672.1  PRKCA-binding protein

      See identical proteins and their annotated locations for NP_001034672.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK092818, BC017561, CN482899
      Consensus CDS
      CCDS13965.1
      UniProtKB/Swiss-Prot
      Q9NRD5
      UniProtKB/TrEMBL
      A0A024R1J5
      Related
      ENSP00000385205, OTTHUMP00000199277, ENST00000404072, OTTHUMT00000321569
      Conserved Domains (2) summary
      cd07659
      Location:146360
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
      smart00228
      Location:1999
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    2. NM_001039584.1NP_001034673.1  PRKCA-binding protein

      See identical proteins and their annotated locations for NP_001034673.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK092818, BC017561
      Consensus CDS
      CCDS13965.1
      UniProtKB/Swiss-Prot
      Q9NRD5
      UniProtKB/TrEMBL
      A0A024R1J5
      Conserved Domains (2) summary
      cd07659
      Location:146360
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
      smart00228
      Location:1999
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    3. NM_012407.3NP_036539.1  PRKCA-binding protein

      See identical proteins and their annotated locations for NP_036539.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AK092818, BC017561
      Consensus CDS
      CCDS13965.1
      UniProtKB/Swiss-Prot
      Q9NRD5
      UniProtKB/TrEMBL
      A0A024R1J5
      Related
      ENSP00000349465, OTTHUMP00000199289, ENST00000356976, OTTHUMT00000321608
      Conserved Domains (2) summary
      cd07659
      Location:146360
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
      smart00228
      Location:1999
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p7 Primary Assembly

      Range
      38056311..38075704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029091.1XP_016884580.1  PRKCA-binding protein isoform X3

    2. XM_017029094.1XP_016884583.1  PRKCA-binding protein isoform X4

      Conserved Domains (1) summary
      cd07659
      Location:18232
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    3. XM_017029095.1XP_016884584.1  PRKCA-binding protein isoform X5

    4. XM_011530517.2XP_011528819.1  PRKCA-binding protein isoform X1

      Conserved Domains (2) summary
      cd07659
      Location:147342
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
      smart00228
      Location:1999
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    5. XM_006724380.2XP_006724443.1  PRKCA-binding protein isoform X4

      See identical proteins and their annotated locations for XP_006724443.1

      Conserved Domains (1) summary
      cd07659
      Location:18232
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    6. XM_006724379.2XP_006724442.1  PRKCA-binding protein isoform X4

      See identical proteins and their annotated locations for XP_006724442.1

      Conserved Domains (1) summary
      cd07659
      Location:18232
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    7. XM_017029093.1XP_016884582.1  PRKCA-binding protein isoform X4

      Conserved Domains (1) summary
      cd07659
      Location:18232
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    8. XM_017029090.1XP_016884579.1  PRKCA-binding protein isoform X2

    9. XM_017029092.1XP_016884581.1  PRKCA-binding protein isoform X2

    RNA

    1. XR_937962.2 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018933.2 Alternate CHM1_1.1

      Range
      38411992..38430442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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