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    CHP1 calcineurin like EF-hand protein 1 [ Homo sapiens (human) ]

    Gene ID: 11261, updated on 6-Aug-2017
    Official Symbol
    CHP1provided by HGNC
    Official Full Name
    calcineurin like EF-hand protein 1provided by HGNC
    Primary source
    HGNC:HGNC:17433
    See related
    Ensembl:ENSG00000187446 MIM:606988; Vega:OTTHUMG00000130233
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHP; p22; p24; Sid470p; SLC9A1BP
    Summary
    This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    15q15.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (41231149..41281887)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41523341..41574085)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 92, member A2 (pseudogene) Neighboring gene RNA, 7SL, cytoplasmic 497, pseudogene Neighboring gene exonuclease 3'-5' domain containing 1 Neighboring gene OIP5 antisense RNA 1 Neighboring gene Opa interacting protein 5

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
      Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
    • Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem (from Pathway Interaction Database)
      Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem
      Calcium signaling in the CD4+ TCR pathway
    • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
      Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
    • Hyaluronan metabolism, organism-specific biosystem (from REACTOME)
      Hyaluronan metabolism, organism-specific biosystemHyaluronan (hyaluronic acid, hyaluronate or HA) is an anionic glycosaminoglycan (GAG) distributed widely throughout connective, epithelial, and neural tissues and most abundant in the extracellular m...
    • Hyaluronan uptake and degradation, organism-specific biosystem (from REACTOME)
      Hyaluronan uptake and degradation, organism-specific biosystemHyaluronan (HA) turnover can occur locally at the tissue of origin, where it is taken up by cells to be degraded, or released into the lymphatic and vascular systems, where it can be eliminated by th...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
      Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
    • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
      Role of Calcineurin-dependent NFAT signaling in lymphocytes
    • T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, organism-specific biosystem (from WikiPathways)
      T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, organism-specific biosystemThis pathway is based on Figure 4 of "A Model of an Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus au...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ20350

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    potassium channel regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    calcium ion regulated exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to acidic pH ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic microtubule organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    hyaluronan catabolic process TAS
    Traceable Author Statement
    more info
     
    membrane docking ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule bundle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of calcineurin-NFAT signaling cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sodium:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    potassium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein oligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of intracellular pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    transport vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    calcineurin B homologous protein 1
    Names
    EF-hand calcium-binding domain-containing protein p22
    SLC9A1 binding protein
    calcineurin B homolog
    calcineurin B-like protein
    calcineurin homologous protein
    calcium binding protein P22
    calcium-binding protein CHP
    calcium-binding protein p22

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007236.4NP_009167.1  calcineurin B homologous protein 1

      See identical proteins and their annotated locations for NP_009167.1

      Status: REVIEWED

      Source sequence(s)
      AC012652
      Consensus CDS
      CCDS10073.1
      UniProtKB/Swiss-Prot
      Q99653
      UniProtKB/TrEMBL
      A0A024R9M9
      Related
      ENSP00000335632.5, OTTHUMP00000160722, ENST00000334660.9, OTTHUMT00000252554
      Conserved Domains (2) summary
      COG5126
      Location:1182
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:114180
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      41231149..41281887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021879.1XP_016877368.1  calcineurin B homologous protein 1 isoform X1

      UniProtKB/TrEMBL
      H0YKE7
      Related
      ENSP00000452772.1, OTTHUMP00000248795, ENST00000560784.5, OTTHUMT00000419051
      Conserved Domains (1) summary
      COG5126
      Location:198
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      41641426..41692297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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