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    ULK2 unc-51 like autophagy activating kinase 2 [ Homo sapiens (human) ]

    Gene ID: 9706, updated on 22-Apr-2017
    Official Symbol
    ULK2provided by HGNC
    Official Full Name
    unc-51 like autophagy activating kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:13480
    See related
    Ensembl:ENSG00000083290 MIM:608650; Vega:OTTHUMG00000059511
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATG1B; Unc51.2
    Summary
    This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
    Orthologs
    Location:
    17p11.2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (19770828..19867926, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19674143..19771239, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 3 family member A1 Neighboring gene TBC1 domain family member 25 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 3 Neighboring gene transfer RNA-Gly (CCC) 3-1 Neighboring gene A-kinase anchoring protein 10 Neighboring gene uncharacterized LOC100131943 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Nanoparticle triggered autophagic cell death, organism-specific biosystem (from WikiPathways)
      Nanoparticle triggered autophagic cell death, organism-specific biosystemProgrammed cell death: autophagic cell death. Autophagy (self-eating) is a survival mechanism deployed by cells to cope with conditions of nutrient deprivation. However, unrestrained autophagy can re...
    • Target Of Rapamycin (TOR) Signaling, organism-specific biosystem (from WikiPathways)
      Target Of Rapamycin (TOR) Signaling, organism-specific biosystemTOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central r...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0623

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon extension IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    pre-autophagosomal structure membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    serine/threonine-protein kinase ULK2
    NP_001136082.1
    NP_055498.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047113.1 RefSeqGene

      Range
      5001..102097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142610.1NP_001136082.1  serine/threonine-protein kinase ULK2

      See identical proteins and their annotated locations for NP_001136082.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB014523, AK314345, AL080134, BC034988, BC039310, DA105030
      Consensus CDS
      CCDS11213.1
      UniProtKB/Swiss-Prot
      Q8IYT8
      Related
      ENSP00000354877.2, OTTHUMP00000065848, ENST00000361658.6, OTTHUMT00000132376
      Conserved Domains (3) summary
      smart00220
      Location:9271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14201
      Location:2272
      STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
      pfam12063
      Location:8641029
      DUF3543; Domain of unknown function (DUF3543)
    2. NM_014683.3NP_055498.3  serine/threonine-protein kinase ULK2

      See identical proteins and their annotated locations for NP_055498.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB014523, AC005722, AK314345, AL080134, BC034988, BC039310, DA105030
      Consensus CDS
      CCDS11213.1
      UniProtKB/Swiss-Prot
      Q8IYT8
      Related
      ENSP00000378914.4, OTTHUMP00000065847, ENST00000395544.8, OTTHUMT00000132375
      Conserved Domains (3) summary
      smart00220
      Location:9271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14201
      Location:2272
      STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
      pfam12063
      Location:8641029
      DUF3543; Domain of unknown function (DUF3543)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      19770828..19867926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025425.1XP_016880914.1  serine/threonine-protein kinase ULK2 isoform X1

    2. XM_017025426.1XP_016880915.1  serine/threonine-protein kinase ULK2 isoform X2

    3. XM_017025424.1XP_016880913.1  serine/threonine-protein kinase ULK2 isoform X1

    4. XM_017025428.1XP_016880917.1  serine/threonine-protein kinase ULK2 isoform X5

    5. XM_017025427.1XP_016880916.1  serine/threonine-protein kinase ULK2 isoform X4

    6. XM_011524087.2XP_011522389.1  serine/threonine-protein kinase ULK2 isoform X3

      Conserved Domains (3) summary
      smart00220
      Location:4153
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12063
      Location:746911
      DUF3543; Domain of unknown function (DUF3543)
      cl21453
      Location:1154
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_001752701.1 RNA Sequence

    2. XR_001752700.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      19683011..19780062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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