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    PLA2G4A phospholipase A2 group IVA [ Homo sapiens (human) ]

    Gene ID: 5321, updated on 7-May-2017
    Official Symbol
    PLA2G4Aprovided by HGNC
    Official Full Name
    phospholipase A2 group IVAprovided by HGNC
    Primary source
    HGNC:HGNC:9035
    See related
    Ensembl:ENSG00000116711 MIM:600522; Vega:OTTHUMG00000035512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    cPLA2; PLA2G4; cPLA2-alpha
    Summary
    This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
    Orthologs
    Location:
    1q31.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (186828900..186989896)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (186798032..186958113)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene prostaglandin-endoperoxide synthase 2 Neighboring gene PTGS2 antisense NFKB1 complex-mediated expression regulator RNA Neighboring gene uncharacterized LOC105371655 Neighboring gene long intergenic non-protein coding RNA 1036

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
    NHGRI GWA Catalog
    Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
    env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of phospholipase A2, group IVA (PLA2G4A) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    • ADP signalling through P2Y purinoceptor 1, organism-specific biosystem (from REACTOME)
      ADP signalling through P2Y purinoceptor 1, organism-specific biosystemCo-activation of P2Y1 and P2Y12 is necessary for complete platelet activation. P2Y1 is coupled to Gq and helps trigger the release of calcium from internal stores, leading to weak and reversible plat...
    • AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
      AGE/RAGE pathway, organism-specific biosystemAdvanced glycation end products (AGEs) are heterogeneous group of non-enzymatic malliard reaction products of aldose sugar with proteins and lipids. Formation of AGEs is an indicator of one of the ma...
    • Acyl chain remodeling of CL, organism-specific biosystem (from REACTOME)
      Acyl chain remodeling of CL, organism-specific biosystemAcyl chain remodeling of cardiolipin (CL) occurs in the inner mitochondria membranes (IM) via hydrolysis by phopholipases and subsequent reacylation by acyltransferases. At the endoplasmic reticulum...
    • Acyl chain remodelling of PC, organism-specific biosystem (from REACTOME)
      Acyl chain remodelling of PC, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylcholine (PC) is hydrolysed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid compos...
    • Acyl chain remodelling of PE, organism-specific biosystem (from REACTOME)
      Acyl chain remodelling of PE, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylethanolamine (PE) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid ...
    • Acyl chain remodelling of PG, organism-specific biosystem (from REACTOME)
      Acyl chain remodelling of PG, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylglycerol (PG) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid comp...
    • Acyl chain remodelling of PI, organism-specific biosystem (from REACTOME)
      Acyl chain remodelling of PI, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylinositol (PI) is hydrolyzed by phospholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid comp...
    • Acyl chain remodelling of PS, organism-specific biosystem (from REACTOME)
      Acyl chain remodelling of PS, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylserine (PS) is hydrolysed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composi...
    • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
      Arachidonic acid metabolism, organism-specific biosystem
      Arachidonic acid metabolism
    • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
      Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
    • Arachidonic acid metabolism, conserved biosystem (from KEGG)
      Arachidonic acid metabolism, conserved biosystem
      Arachidonic acid metabolism
    • COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
      COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystemIn addition to the better characterized COPI-dependent retrograde Golgi-to-ER pathway, a second COPI-independent pathway has also been identified. This pathway is RAB6 dependent and transports cargo...
    • Ca-dependent events, organism-specific biosystem (from REACTOME)
      Ca-dependent events, organism-specific biosystemCalcium, as the ion Ca2+, is essential in many biological processes. The majority of Ca2+ in many organisms is bound to phosphates which form skeletal structures and also buffer Ca2+ levels in extrac...
    • Choline metabolism in cancer, organism-specific biosystem (from KEGG)
      Choline metabolism in cancer, organism-specific biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
    • Choline metabolism in cancer, conserved biosystem (from KEGG)
      Choline metabolism in cancer, conserved biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
    • Endothelins, organism-specific biosystem (from Pathway Interaction Database)
      Endothelins, organism-specific biosystem
      Endothelins
    • Ether lipid metabolism, organism-specific biosystem (from KEGG)
      Ether lipid metabolism, organism-specific biosystem
      Ether lipid metabolism
    • Ether lipid metabolism, conserved biosystem (from KEGG)
      Ether lipid metabolism, conserved biosystem
      Ether lipid metabolism
    • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
      Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
      Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
      Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
      Fc-epsilon receptor I signaling in mast cells
    • G-protein mediated events, organism-specific biosystem (from REACTOME)
      G-protein mediated events, organism-specific biosystemWhen dissociated Galpha-GTP and Gbeta-gamma can activate or inhibit different signalling cascades and effector proteins. The precise pathways depends on the identity of the alpha and beta/gamma subty...
    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
      Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
    • Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
      Glycerophospholipid metabolism, organism-specific biosystem
      Glycerophospholipid metabolism
    • Glycerophospholipid metabolism, conserved biosystem (from KEGG)
      Glycerophospholipid metabolism, conserved biosystem
      Glycerophospholipid metabolism
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
      Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hydrolysis of LPC, organism-specific biosystem (from REACTOME)
      Hydrolysis of LPC, organism-specific biosystemLysophosphatidylcholine (LPC) is hydrolyzed by phospholipases to produce glycerophosphocholine (GPCho) which is in turn hydrolyzed by glycerophosphocholine phosphodiesterase to produce choline (Cho) ...
    • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
      Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
    • Linoleic acid metabolism, organism-specific biosystem (from KEGG)
      Linoleic acid metabolism, organism-specific biosystem
      Linoleic acid metabolism
    • Linoleic acid metabolism, conserved biosystem (from KEGG)
      Linoleic acid metabolism, conserved biosystem
      Linoleic acid metabolism
    • Long-term depression, organism-specific biosystem (from KEGG)
      Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • Long-term depression, conserved biosystem (from KEGG)
      Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Nanoparticle triggered regulated necrosis, organism-specific biosystem (from WikiPathways)
      Nanoparticle triggered regulated necrosis, organism-specific biosystemProgrammed cell death: regulated necrosis. During regulated necrosis, different stimuli are recognized or sensed by specific receptors on the cell surface or inside cells. The activation of the necro...
    • Opioid Signalling, organism-specific biosystem (from REACTOME)
      Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
    • Ovarian steroidogenesis, organism-specific biosystem (from KEGG)
      Ovarian steroidogenesis, organism-specific biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
    • Ovarian steroidogenesis, conserved biosystem (from KEGG)
      Ovarian steroidogenesis, conserved biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
    • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
      Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Oxytocin signaling pathway, conserved biosystem (from KEGG)
      Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • PDGF Pathway, organism-specific biosystem (from WikiPathways)
      PDGF Pathway, organism-specific biosystemPDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; H...
    • PLC beta mediated events, organism-specific biosystem (from REACTOME)
      PLC beta mediated events, organism-specific biosystemThe phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. PLC hydrolyzes phosphatidylinosito...
    • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
      Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
      Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
      Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...
    • Platelet activation, organism-specific biosystem (from KEGG)
      Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
    • Platelet sensitization by LDL, organism-specific biosystem (from REACTOME)
      Platelet sensitization by LDL, organism-specific biosystemPhysiological concentrations (1g/L) of Low density lipoprotein (LDL) enhance platelet aggregation responses initiated by thrombin, collagen, and ADP. This enhancement involves the rapid phosphorylati...
    • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
      Prostaglandin Synthesis and Regulation, organism-specific biosystemA prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon ato...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Serotonergic synapse, organism-specific biosystem (from KEGG)
      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signal amplification, organism-specific biosystem (from REACTOME)
      Signal amplification, organism-specific biosystemIn the initial response to injury, platelets adhere to damaged blood vessels, responding to the exposure of collagen from the vascular epithelium. Once adhered they degranulate, releasing stored seco...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
      Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
      Signaling mediated by p38-alpha and p38-beta
    • Synthesis of PA, organism-specific biosystem (from REACTOME)
      Synthesis of PA, organism-specific biosystemIn the de novo synthesis of phosphatidic acid (PA), lysophosphatidic acid (LPA) is initially formed by the esterification of sn-1 by glycerol 3-phosphate acyltransferase (GPAT) from glycerol 3-phosph...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • alpha-Linolenic acid metabolism, organism-specific biosystem (from KEGG)
      alpha-Linolenic acid metabolism, organism-specific biosystem
      alpha-Linolenic acid metabolism
    • alpha-Linolenic acid metabolism, conserved biosystem (from KEGG)
      alpha-Linolenic acid metabolism, conserved biosystem
      alpha-Linolenic acid metabolism
    • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...
    • phospho-PLA2 pathway, organism-specific biosystem (from REACTOME)
      phospho-PLA2 pathway, organism-specific biosystemPhospholipase A2 (PLA2) enzymes hydrolyze arachidonic acid (AA) from the sn-2 position of phospholipids. AA is a precursor of eicosanoids, lipid mediators involved in inflammtory responses. PLA2 enzy...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC126350

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent phospholipase A2 activity EXP
    Inferred from Experiment
    more info
    PubMed 
    calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysophospholipase activity TAS
    Traceable Author Statement
    more info
     
    phosphatidylcholine 1-acylhydrolase activity TAS
    Traceable Author Statement
    more info
     
    phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipase A2 activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    phospholipase A2 activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    arachidonic acid metabolic process TAS
    Traceable Author Statement
    more info
     
    arachidonic acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    cardiolipin acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    cellular response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
     
    icosanoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    icosanoid metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    phosphatidylcholine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phosphatidylethanolamine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phosphatidylglycerol acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phosphatidylserine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid metabolic process TAS
    Traceable Author Statement
    more info
     
    platelet activating factor biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    lipid particle IDA
    Inferred from Direct Assay
    more info
     
    mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    cytosolic phospholipase A2
    Names
    calcium-dependent phospholipid-binding protein
    lysophospholipase
    phosphatidylcholine 2-acylhydrolase
    phospholipase A2, group IVA (cytosolic, calcium-dependent)
    NP_001298122.1
    NP_077734.1
    XP_005245324.2
    XP_011507944.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012203.1 RefSeqGene

      Range
      5001..165082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001311193.1NP_001298122.1  cytosolic phospholipase A2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK302938, AL022147, BC114340, BX118890
      UniProtKB/Swiss-Prot
      P47712
      UniProtKB/TrEMBL
      B4DZI4
      Conserved Domains (3) summary
      cd07200
      Location:114670
      cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:20129
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam01735
      Location:130614
      PLA2_B; Lysophospholipase catalytic domain
    2. NM_024420.2NP_077734.1  cytosolic phospholipase A2 isoform 1

      See identical proteins and their annotated locations for NP_077734.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL022147, BC114340, BX118890, DA451491, M72393
      Consensus CDS
      CCDS1372.1
      UniProtKB/Swiss-Prot
      P47712
      Related
      ENSP00000356436.3, OTTHUMP00000033543, ENST00000367466.3, OTTHUMT00000086236
      Conserved Domains (3) summary
      cd07200
      Location:144730
      cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:20138
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      smart00022
      Location:117669
      PLAc; Cytoplasmic phospholipase A2, catalytic subunit

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      186828900..186989896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509642.2XP_011507944.1  cytosolic phospholipase A2 isoform X2

      See identical proteins and their annotated locations for XP_011507944.1

      UniProtKB/Swiss-Prot
      P47712
      Conserved Domains (3) summary
      cd07200
      Location:144730
      cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:20138
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      smart00022
      Location:117669
      PLAc; Cytoplasmic phospholipase A2, catalytic subunit
    2. XM_005245267.3XP_005245324.2  cytosolic phospholipase A2 isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      188219298..188379410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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